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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Abrogation of Thioacetamide-Induced Biochemical Events of Hepatic Tumor Promotion Stage by Tannic Acid in Wistar Rats

Volume 26, Edição 1, 2007, pp. 9-20
DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i1.20
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RESUMO

Tannic acid is present in almost every edible plant and is generally used as a safe food additive. In this study we investigated the antioxidative and antihyperproliferative potential of tannic acid against thioacetoamide (TAA), a potent hepatotoxic-substance-induced oxidative stress and hyperproliferation biomarker. We have shown here that the activities of hepatic antioxidant enzymes, phase II metabolizing enzymes, and the glutathione content were decreased while hepatic ornithine decarboxylase activity and DNA synthesis were induced in TAA-treated animals. Tannic acid administration at two different doses prior to the TAA injection partially recovered the depleted level of glutathione, inhibited activities of antioxidant and phase II metabolizing enzymes, and resulted in significant inhibition of oxidative stress in a dose-dependent manner. Tannic acid administration before TAA treatment also resulted in a significant decrease in ODC activity and [3H]-thymidine incorporation in rat liver, which are classical markers of inflammation and tumor promotion. Our data clearly demonstrate that tannic acid possesses antioxidant and antiproliferating activities because it inhibits early biomarkers of TAA-induced tumor promotion in an in vivo animal model.

CITADO POR
  1. Afonso Jordao Alceu, Lima Sanchez Sheila Cristina, Vannucchi Portari Guilherme, Aparecida Domenici Fernanda, Vannucchi Helio, Vitamin E and tannic acid improve DNA damage in rats submitted chronic ethanol administration, British Food Journal, 112, 6, 2010. Crossref

  2. Nafees S, Ahmad ST, Arjumand W, Rashid S, Ali N, Sultana S, Carvacrol ameliorates thioacetamide-induced hepatotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in liver of Wistar rats, Human & Experimental Toxicology, 32, 12, 2013. Crossref

  3. Pithayanukul Pimolpan, Nithitanakool Saruth, Bavovada Rapepol, Hepatoprotective Potential of Extracts from Seeds of Areca catechu and Nutgalls of Quercus infectoria, Molecules, 14, 12, 2009. Crossref

  4. Wang Zuo, Yin Lei, Liu Lei, Lan Xinyi, He Jianhua, Wan Fachun, Shen Weijun, Tang Shaoxun, Tan Zhiliang, Yang Yanming, Tannic acid reduced apparent protein digestibility and induced oxidative stress and inflammatory response without altering growth performance and ruminal microbiota diversity of Xiangdong black goats, Frontiers in Veterinary Science, 9, 2022. Crossref

  5. Wang Zuo, Zhao Yuan, Lan Xinyi, He Jianhua, Wan Fachun, Shen Weijun, Tang Shaoxun, Zhou Chuanshe, Tan Zhiliang, Yang Yanming, Tannic acid supplementation in the diet of Holstein bulls: Impacts on production performance, physiological and immunological characteristics, and ruminal microbiota, Frontiers in Nutrition, 9, 2022. Crossref

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