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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Investigation on the Genotoxic Effects of Long-Term Administration of Sodium Arsenite in Bone Marrow and Testicular Cells In Vivo Using the Comet Assay

Volume 26, Edição 1, 2007, pp. 29-37
DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i1.40
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RESUMO

The main source of environmental arsenic exposure in most populations is drinking water in which inorganic forms of arsenic predominate. The single-cell gel electrophoresis technique (the comet assay) measures DNA damage, including double-strand and single-strand breaks, in somatic cells after a variety of genotoxic insults. We have used this method to measure damage to cellular DNA in the bone marrow and testicular cells of mice using the alkaline comet assay for the former and neutral comet assay for the latter. Swiss albino male mice were exposed to sodium arsenite in drinking water at concentrations of 10, 50,100, and 200 mg/l for a period of three months. Concurrently, negative and positive control sets were maintained. The negative control animals were given distilled water as drinking water for the same period of treatment while the animals in positive control sets were either given single or multiple injections of EMS (100 mg/kg body weight) according to the tissue sampled. Following long-term exposure, there was a significant dose-dependent reduction in the size and weight of testes. The comet parameters of DNA, such as tail length (μm), % of DNA in tail, and Olive tail moment (arbitrary units) were increased in both bone marrow and testicular cells due to arsenic-induced DNA strand breaks. A positive dose response relationship was noted. The magnitude of DNA strand break was more pronounced in the bone marrow cells than in the testicular cells. The minimum effective concentrations for inducing DNA damage in bone marrow cells and testicular cells were 10 mg/l and 50 mg/l, respectively. The results of the study indicate that arsenic in drinking water is genotoxic in mice and the comet assay can be used for examining DNA damage in testicular cells as a parameter for evaluating male reproductive toxicity.

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