Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Journal of Environmental Pathology, Toxicology and Oncology
Fator do impacto: 1.241 FI de cinco anos: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i1.10
pages 1-6

Oxidative Stress−Mediated Apoptotic Death in Human Peripheral Blood Lymphocytes Treated with Plasma from Gamma-Irradiated Blood

R. Vasumathy
Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
Badri Narain Pandey
Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
Kaushala Prasad Mishra
Department of Life Sciences, University of Mumbai, Mumbai, India; Nehru Gram Bharati University, Allahabad, UP, India; Foundation for Education and Research, India and BM International Research Centre, Mumbai, India

RESUMO

The present study is aimed to investigate the effect of plasma from irradiated human blood on the induction of apoptotic death in human peripheral blood lymphocytes. Our results showed that plasma obtained from γ-irradiated human blood showed a significant decrease in viability and an increase in apoptotic death in unirradiated lymphocytes, which is correlated with increase in intracellular reactive oxygen species level. Moreover, a decrease in the activity of superoxide dismutase in lymphocytes further seems to be associated with oxidative stress−mediated apoptotic death. The diffusible factors from irradiated blood were found to be generated from the cellular components of blood. Based on our results, we suggest induction of oxidative stress−mediated apoptotic death in unirradiated lymphocytes by diffusible factors from irradiated blood.


Articles with similar content:

Modification of Thymocytes Membrane Radiooxidative Damage and Apoptosis by Eugenol
Journal of Environmental Pathology, Toxicology and Oncology, Vol.23, 2004, issue 2
Kaushala Prasad Mishra, Badri Narain Pandey
Radioprotective Effect of Carvacrol Against X-Radiation−Induced Cellular Damage in Cultured Human Peripheral Blood Lymphocytes
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 3
Nisha Susan Thomas, Thayalan Kuppusamy, Nalini Namashivayam, Sivaranjani Arivalagan
Bystander Effect of Conditioned Medium from Low and High Doses of γ-irradiated Human Leukemic Cells on Normal Lymphocytes and Cancer Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 4
Amit Kumar, Kaushala Prasad Mishra, Badri Narain Pandey, Manjoor Ali
Biochanin A Enhances the Radiotoxicity in Colon Tumor Cells In Vitro
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 3
Reeta Tiwari, Abhay Puthli, Kaushala Prasad Mishra
Black Tea Extract: A Supplementary Antioxidant in Radiation-Induced Damage to DNA and Normal Lymphocytes
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 2
Salil C. Datta , Subrata Kumar Dey, Sandip Pal, Amit Kumar Chakrabarti, Debjani Ghosh, Chabita Saha