Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
Indexed in
Expression of NF-κB and ERK Following Heavy Ion Irradiation
RESUMO
Heavy ion irradiation of cells is known to increase cytotoxic, mutagenic, and carcinogenic effects. The increased biological effectiveness of these ions is as yet unexplained, except for the fact that, unlike γ-radiation, they result in clustered damage. It is likely that the increased biological effectiveness is a consequence of altered signaling pattern, which in turn may be due to the difference in the nature of damage produced. Gamma irradiation has been known to activate both pro- and anti-apoptotic signaling pathways. Nuclear factor-κB (NF-κB) and extracellular signal regulated kinase (ERK) contribute to the survival of the irradiated cell. Moreover, NF-κB acts as a redox sensor. In the present study, we examined NF-κB and ERK as antiapoptotic factors that could lead to the inhibition of apoptosis and, consequently, to increased mutagenicity. Both these signaling factors show a fluctuation in their levels with time.
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Narang Himanshi, Bhat Nagesh, Gupta S. K., Santra S., Choudhary R. K., Kailash S., Krishna Malini, Differential activation of mitogen-activated protein kinases following high and low LET radiation in murine macrophage cell line, Molecular and Cellular Biochemistry, 324, 1-2, 2009. Crossref
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Hellweg Christine E., Baumstark-Khan Christa, Schmitz Claudia, Lau Patrick, Meier Matthias M., Testard Isabelle, Berger Thomas, Reitz Günther, Activation of the Nuclear Factor κB pathway by heavy ion beams of different linear energy transfer, International Journal of Radiation Biology, 87, 9, 2011. Crossref
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Hellweg Christine E, Baumstark-Khan Christa, Schmitz Claudia, Lau Patrick, Meier Matthias M, Testard Isabelle, Berger Thomas, Reitz Günther, Carbon-Ion-Induced Activation of the NF-κB Pathway, Radiation Research, 175, 4, 2011. Crossref
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Fujita Mayumi, Imadome Kaori, Shoji Yoshimi, Isozaki Tetsurou, Endo Satoshi, Yamada Shigeru, Imai Takashi, Carbon-Ion Irradiation Suppresses Migration and Invasiveness of Human Pancreatic Carcinoma Cells MIAPaCa-2 via Rac1 and RhoA Degradation, International Journal of Radiation Oncology*Biology*Physics, 93, 1, 2015. Crossref
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Hellweg Christine E., The Nuclear Factor κB pathway: A link to the immune system in the radiation response, Cancer Letters, 368, 2, 2015. Crossref
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Zhang Ye, Moreno-Villanueva Maria, Krieger Stephanie, Ramesh Govindarajan, Neelam Srujana, Wu Honglu, Transcriptomics, NF-κB Pathway, and Their Potential Spaceflight-Related Health Consequences, International Journal of Molecular Sciences, 18, 6, 2017. Crossref
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Han Ying-Hao, Kwon Jeong-Hoon, Yu Dae-Yeul, Moon Eun-Yi, Inhibitory effect of peroxiredoxin II (Prx II) on Ras–ERK–NFκB pathway in mouse embryonic fibroblast (MEF) senescence, Free Radical Research, 40, 11, 2006. Crossref