Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Journal of Environmental Pathology, Toxicology and Oncology
Fator do impacto: 1.241 FI de cinco anos: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvPathToxOncol.v23.i3.20
16 pages

On the Safety of Reduced Nicotinamide Adenine Dinucleotide (NADH)

Karl F. R. Nadlinger
Department of Research & Development, Birkmayer Laboratories, Vienna, Austria
Seth Hallstrom
Department of Research & Development, Birkmayer Laboratories; and Institute for Medical Chemistry and Pregl-Laboratory, Medical University of Graz, Vienna, Austria

RESUMO

The objective of the study was to determine both the toxicity of the stabilized orally absorbable form of nicotinamide adenine dinucleotide (NADH) (ENADA®) and the maximum tolerated intravenous dose (MTD) of βNADH (the reduced form of NADH) in beagle dogs. The administration of the stabilized orally absorbable form of NADH to beagle dogs at dose levels of 20, 100, and 150 mg/kg for 14 days elicited no signs of a toxicological effect. A transitory change in stool formation was observed with the intermediate and high dose in males. There were also apparent increases in adrenal, heart, kidney, liver, brain, and thyroid weights, particularly in males, but none of these changes were considered to be toxicologically significant. In addition, four dogs (two of each sex) received intravenous infusions of 100 mg NADH/kg/day for 4 days, followed by 200 mg NADH/kg/day for 3 days, followed by 500 mg NADH/kg/day for 4 days, and 1000 mg NADH/kg/day on the final day. At the end of the MTD phase, the control animals that had received saline solution in the MTD phase were used to evaluate the potential toxicity of the established MTD. These animals received 500 mg NADH/kg/day for 14 days (fixed dose phase). There were no deaths. At dose levels between 100 and 1000 mg/kg/day, effects on the cardiovascular system and also some evidence of an effect on the central nervous system and on the adrenals were observed. At doses of 500 mg/kg/day and above, food consumption and body weight were reduced. On the basis of the observed changes, the maximum intravenous dose of NADH tolerated by beagle dogs was considered to be 500 mg/kg/day. There were no gross histological findings indicative of toxicity in the organs of tissues examined. Based on these findings, the stabilized orally absorbable form of NADH (ENADA) can be regarded as safe.


Articles with similar content:

Effects of Concurrently Administered Aqueous Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Lead Acetate in Rats
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 2
Michael T. Sobowale, Raymond I. Ozolua, Buniyamin A. Ayinde, Dickson O. Uwaya
Reversal of Lead-Induced Toxicity Due to the Effect of Antioxidants
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 2
Sadhana Shrivastava, Samta Sharma, Sangeeta Shukla
Histopathological, Enzymatic, and Molecular Alterations Induced By Cigarette Smoke Inhalation in the Pulmonary Tissue of Mice and Its Amelioration By Aqueous Azadirachta Indica Leaf Extract
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 1
Ashwani Koul, Sanjay Bharati, Neha Kapoor
Effect of Bioactive Ceramic and Recombinant Human Transforming Growth Factor-Beta (rhTGF-beta) on Regeneration of Parietal Bone Defects in Rat
Journal of Long-Term Effects of Medical Implants, Vol.21, 2011, issue 1
Fariborz Nasseri, Mahdi Kadkhodazadeh, Gholam Ali Gholami
Nephroprotective Effect of Jaggery against Acute and Subchronic Toxicity of Acetaminophen in Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 3
Vinay Sharma, Chandra Kant Sharma