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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Radioprotection by Copper and Zinc Complexes of 5-Aminosalicylic Acid: A Preliminary Study

Volume 27, Edição 2, 2008, pp. 123-134
DOI: 10.1615/JEnvironPatholToxicolOncol.v27.i2.50
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RESUMO

The effect of copper and zinc complexes of 5-aminosalicylic acid (hereafter referred to as Cu-5ASA and Zn-5ASA, respectively) against whole-body gamma radiation—induced cytotoxicity was studied in Swiss albino mice. Protection against lethal irradiation was evaluated from 30 day mouse survival (10 Gy) and endogenous spleen colony assay (11 Gy); and against sublethal dose (4 Gy) was assessed from gamma irradiation (RT)—induced formation of micronuclei in the mouse bone marrow 24 h postirradiation. Pretreatment with either Cu-5ASA (2.5−9 mg/kg) or Zn-5ASA (3.5−14 mg/kg) intraperitoneally (i.p.) delayed and reduced percentage mortality in mice exposed to 10 Gy RT. The doses 9 mg/kg for Cu-5ASA and 7 mg/kg for Zn-5ASA were found to be the most effective dose in preventing RT-induced weight loss and reducing percentage mortality. Both the drugs also caused an increase in the endogenous spleen colonies in mouse exposed to 11 Gy RT. At sublethal doses of RT, pretreatment with either Cu-5ASA or Zn-5ASA resulted in a significant decrease in the RT-induced micronucleated polychromatic erythrocytes and normochromatic erythrocytes (MPCEs and MNCEs) and an increase in the ratio of PCE to NCE (P/N), at 24 h postirradiation. These results show that both Cu-5ASA and Zn-5ASA are effective in protecting normal tissues against lethal and sublethal doses of RT. Further pretreatment with either Cu-5ASA or Zn-5ASA enhanced the survival of tumor-bearing mice (Ehrlich's ascites carcinoma) exposed to 7.5 Gy RT. In fact, both the complexes caused an increase in the mean and average survival times (MST and AST) when compared to the irradiated control, suggesting a synergetic effect of these drugs with radiation in causing cytotoxicity to the tumor cells. The data clearly indicate that both Cu-5ASA and Zn-5ASA significantly reduced the deleterious effect of radiation and hence could be useful agents in reducing the side effects of therapeutic radiation.

CITADO POR
  1. Han Li-Jun, Yang Shu-Ping, Pan Yan, Wang Da-Qi, Syntheses, Crystal Structures, and Antibacterial Activities of the Cu(II) Complex {Cu2[5-(NO2)sal]2 (DMF)4}2 and Co(II) Complex{Co[5-(NO2)sal] (H2O)3}2, Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 44, 6, 2014. Crossref

  2. El-Sokkary A. M. A., El-Naggar M. M., Abdel-Aziz A. F., Mostafa M. M., Copper(II)-Girard's T complex as a promising anti-tumor agent, Applied Organometallic Chemistry, 2010. Crossref

  3. Nejaim Yuri, I. V. Silva Amaro, V. Vasconcelos Taruska, J. N. L. Silva Emmanuel, M. de Almeida Solange, Evaluation of radioprotective effect of aloe vera and zinc/copper compounds against salivary dysfunction in irradiated rats, Journal of Oral Science, 56, 3, 2014. Crossref

  4. Hosseinimehr Seyed Jalal, The protective effects of trace elements against side effects induced by ionizing radiation, Radiation Oncology Journal, 33, 2, 2015. Crossref

  5. Demirel Can, Kilciksiz Sevil Cagiran, Gurgul Serkan, Erdal Nurten, Yigit Seyran, Tamer Lulufer, Ayaz Lokman, Inhibition of Radiation-Induced Oxidative Damage in the Lung Tissue: May Acetylsalicylic Acid Have a Positive Role?, Inflammation, 39, 1, 2016. Crossref

  6. Klein Couto Gabriela, Rodrigues João Carlos, Pacheco Bruna Silveira, Damé Simões Lucas, Paschoal Júlia Damé, Seixas Fabiana Kommling, Acunha Thiago V., Iglesias Bernardo Almeida, Collares Tiago, Zinc(II), copper(II) and nickel(II) ions improve the selectivity of tetra-cationic platinum(II) porphyrins in photodynamic therapy and stimulate antioxidant defenses in the metastatic melanoma lineage (A375), Photodiagnosis and Photodynamic Therapy, 31, 2020. Crossref

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