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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Carotenoid Lutein Protects the Kidney against Cisplatin-Induced Acute Renal Failure

Volume 32, Edição 1, 2013, pp. 21-28
DOI: 10.1615/JEnvironPatholToxicolOncol.2013004933
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RESUMO

Cisplatin is one of the most potent anticancer drugs available for the treatment of a variety of tumors. One of the side effects of this drug is nephrotoxicity. Current research evidence indicates that the renal toxicity is mainly due to the reactive oxygen molecules generated by cisplatin. In the present study, we evaluated the nephroprotective activity of lutein, a non-toxic carotenoid with strong antioxidant activity, to reduce cisplatin-induced renal damage in mice. Serum urea and creatinine levels in the cisplatin-induced mice were significantly elevated compared to those of the control group, and nephrotoxicity was reduced by the lutein treatments (P<0.01). In the cisplatin-treated control group as well as in the vehicle control group, antioxidant enzymes in the kidney, such as superoxide dismutase, as well as catalase activity and level of reduced glutathione were reduced, and the level of malondialdehyde was elevated. Antioxidant enzymes were significantly increased by lutein treatment, and the level of malondialdehyde declined significantly in lutien-treated mice. White blood cell count and bone marrow cellularity, which were significantly reduced in the cisplatin-treated group, were also significantly elevated in all lutein-treated groups (P<0.001). The results of the study show that lutein effectively protected the kidneys of mice treated with cisplatin; these results are also supported by the histopathologies of the kidney tissues of treated mice.

CITADO POR
  1. Al-Okbi Sahar Y., Mohamed Doha A., Hamed Thanaa E., Esmail Reham SH., Donya Souria M., Prevention of renal dysfunction by nutraceuticals prepared from oil rich plant foods, Asian Pacific Journal of Tropical Biomedicine, 4, 8, 2014. Crossref

  2. LIU ZHEN-GUO, QI ZONG-CAI, LIU WEI-LIANG, WANG WEI-ZHI, Lutein protects against ischemia/reperfusion injury in rat kidneys, Molecular Medicine Reports, 11, 3, 2015. Crossref

  3. Cheng Fang, Zhang Qian, Yan Feng-Feng, Wan Jun-Fang, Lin Chun-Shui, Lutein protects against ischemia/reperfusion injury in rat skeletal muscle by modulating oxidative stress and inflammation, Immunopharmacology and Immunotoxicology, 37, 4, 2015. Crossref

  4. Hassan Mohammed S., Morgan Ashraf M., Mekawy Mohey M., Zaki Amr R., Ghazi Zeinab M., Teratogenic effect of cisplatin in rats and the protective role of sodium selenate, Experimental and Toxicologic Pathology, 68, 5, 2016. Crossref

  5. Pund Swati, Joshi Amita, Patravale Vandana, Improving bioavailability of nutraceuticals by nanoemulsification, in Nutraceuticals, 2016. Crossref

  6. Zhang Dongxue, Wang Lina, Zhang Xin, Bao Decai, Zhao Yanjun, Polymeric micelles for pH-responsive lutein delivery, Journal of Drug Delivery Science and Technology, 45, 2018. Crossref

  7. Różanowska Małgorzata B., Czuba-Pelech Barbara, Landrum John T., Różanowski Bartosz, Comparison of Antioxidant Properties of Dehydrolutein with Lutein and Zeaxanthin, and their Effects on Cultured Retinal Pigment Epithelial Cells, Antioxidants, 10, 5, 2021. Crossref

  8. Pang Mengxue, Duan Songchao, Zhao Mengmeng, Jiao Qingqing, Bai Yimeng, Yu Lili, Du Bin, Cheng Genyang, Co-delivery of celastrol and lutein with pH sensitive nano micelles for treating acute kidney injury, Toxicology and Applied Pharmacology, 450, 2022. Crossref

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