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Nanoscience and Technology: An International Journal

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ISSN Imprimir: 2572-4258

ISSN On-line: 2572-4266

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.7 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.7 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.11 SJR: 0.244 SNIP: 0.521 CiteScore™:: 3.6 H-Index: 14

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NANOTECHNOLOGY-BASED STRATEGIES FOR NUTRACEUTICALS: A REVIEW OF CURRENT RESEARCH DEVELOPMENT

Volume 10, Edição 2, 2019, pp. 133-155
DOI: 10.1615/NanoSciTechnolIntJ.2019030098
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RESUMO

With time people are becoming more health conscious and demanding for safer and healthier food products. There is an annual growth of 7% in the nutraceutical industry and by the year 2020 it is projected to be worth 35 billion with Asia Pacific growing the fastest. Nutraceuticals utilize materials that have potential to control many diseases, but due to the fact that a lot of biotransformations take place within the body, the compounds are unable to show effects as expected. Recent progress in the field of nutraceutical development has been extended from microsize to nanodimensions. A current research scenario indicates that nanotization strategies of drugs have served as a potential approach to enhance the solubility and bioavailability and to develop a robust formulation. This review focuses on issues associated with conventional nutraceuticals, current nutraceutical market scenario worldwide, and various nanoscale formulation approaches like liposomes, nanoemulsions, nanocrystals, lipid and polymeric nanoparticles have been discussed in detail to obtain an insight into recent developments in nutraceutical segment.

Referências
  1. Acosta, E., Bioavailability of Nanoparticles in Nutrient and Nutraceuticals Delivery, Current Opinion Colloid Interface Sci., vol. 14, no. 1, pp. 3-15, 2000.

  2. Ahmad, U., Akhtar, J., Singh, S.P., Badruddeen, Ahmad, F.J., Siddiqui, S., and Wahajuddin, Silymarin Nanoemulsion against Human Hepatocellular Carcinoma: Development and Optimization, Artificial Cell Nanomed. B, pp. 1-11, 2017.

  3. Ahmad, U., Faiyazuddin, M., Hussain, M.T., Ahmad, S., Alshammari, T.M., and Shakeel, F., Silymarin: An Insight to Its Formulation and Analytical Prospects, Acta Physiol. Plant, vol. 37, no. 11, pp. 1-17, 2015a.

  4. Ahmad, U., Hussain, M.T., and Faiyazuddin, M., Nanotechnology-Based Chemopreventive Approaches to Improve the Oral Delivery of Silymarin in Liver Cancer, in Nanotechnology: Novel Perspectives and Prospects, B. Singh, A. Kaushik, S.K. Mehta, and S.K. Tripathi, Eds., New York: McGraw Hill Education, pp. 809-817, 2015b.

  5. Ali, A., Ansari, V.A., Ahmad, U., Akhtar, J., and Jahan, A., Nanoemulsion: An Advanced Vehicle for Efficient Drug Delivery, Drug Res., vol. 67, no. 11, pp. 617-631, 2017.

  6. Ames, B.N., Shigenaga, M.K., and Hagen, T.M., Oxidants, Antioxidants, and the Degenerative Diseases of Aging, Proc. Natl. Acad. Sci., vol. 90, no. 17, pp. 7915-7922, 1993.

  7. Amri, A., Chaumeil, J.C., Sfar, S., and Charrueau, C., Administration of Resveratrol: What Formulation Solutions to Bioavailability Limitations?, J. Controlled Release, vol. 158, no. 2, pp. 182-193, 2012.

  8. Arunkumar, R., Prashanth, K.V.H., and Baskaran, V., Promising Interaction between Nanoencapsulated Lutein with Low Molecular Weight Chitosan: Characterization and Bioavailability of Lutein In Vitro and In Vivo, Food Chem., vol. 141, no. 1, pp. 327-337, 2013.

  9. Augustin, M.A., Sanguansri, L., and Lockett, T., Nano- and Micro-Encapsulated Systems for Enhancing the Delivery of Resveratrol, Ann. N.Y. Acad. Sci, vol. 1290, no. 1, pp. 107-112, 2013.

  10. Austin, M.A., Plasma Triglyceride and Coronary Heart Disease, Arterioscl. Throm. Vasc., vol. 11, no. 1, pp. 2-14, 1991.

  11. Boyd, B.J., Past and Future Evolution in Colloidal Drug Delivery Systems, Expert Opinion Drug Delivery, vol. 5, no. 1, pp. 69-85, 2008.

  12. Brandl, M., Liposomes as Drug Carriers: A Technological Approach, Biotechnol. Ann. Rev., vol. 7, pp. 59-85, 2001.

  13. Brower, V., Nutraceuticals: Poised for a Healthy Slice of the Healthcare Market?, Nature Biotechnol., vol. 16, pp. 728-732, 1998.

  14. Campardelli, R. and Reverchon, E., a-Tocopherol Nanosuspensions Produced Using a Supercritical Assisted Process, J. Food Eng., vol. 149, pp. 131-136, 2015.

  15. Cavalli, R., Caputo, O., and Gasco, M.R., Solid Lipospheres of Doxorubicin and Idarubicin, Int. J. Pharm., vol. 89, no. 1, pp. R9-R12, 1993.

  16. Chen, L., Remondetto, G.E., and Subirade, M., Food Protein-Based Materials as Nutraceuticals Delivery Systems, Trends Food Sci. Technol., vol. 17, no. 5, pp. 272-283, 2006.

  17. Chung, M.J., Sung, N.J., Park, C.S., Kweon, D.K., Mantovani, A., Moon, T.W., et al., Antioxidative and Hypocholesterolemic Activities of Water-Soluble Puerarin Glycosides in HepG2 Cells and in C57 BL/6J Mice, Eur. J. Pharmacol, vol. 578, no. 2, pp. 159-170, 2008.

  18. De Britto, D., de Moura, M.R., Aouada, F.A., Mattoso, L.H., and Assis, O.B., N, N, N-Trimethyl Chitosan Nanoparticles as a Vitamin Carrier System, Food Hydrocolloids, vol. 27, no. 2, pp. 487-493, 2012.

  19. Dickinson, E., Food Emulsions and Foams: Stabilization by Particles, Current Opinion Colloid Interface Sci., vol. 15, no. 1, pp. 40-49, 2010.

  20. Dickinson, E., Use of Nanoparticles and Microparticles in the Formation and Stabilization of Food Emulsions, Trends Food Sci. Technol., vol. 24, no. 1, pp. 4-12, 2012.

  21. Dubbs, M.D. and Gupta, R.B., Solubility of Vitamin E (a-tocopherol) and Vitamin K3 (Menadione) in Ethanol-Water Mixture, J. Chem. Eng. Data, vol. 43, no. 4, pp. 590-591, 1998.

  22. Dureja, H., Kaushik, D., and Kumar, V., Developments in Nutraceuticals, Indian J. Pharmacol., vol. 35, no. 6, pp. 363-372, 2003.

  23. Fang, M., Jin, Y., Bao, W., Gao, H., Xu, M., Wang, D., and Liu, L., In Vitro Characterization and In Vivo Evaluation of Nanostructured Lipid Curcumin Carriers for Intragastric Administration, Int. J. Nanomed, vol. 7, pp. 5395-5404, 2011.

  24. Fathi, M., Mozafari, M.R., and Mohebbi, M., Nanoencapsulation of Food Ingredients Using Lipid Based Delivery Systems, Trends Food Sci. Technol., vol. 23, no. 1, pp. 13-27, 2012.

  25. Flanagan, J. and Singh, H., Microemulsions: A Potential Delivery System for Bioactives in Food, Crit. Rev. Food Sci, vol. 46, no. 3, pp. 221-237, 2006.

  26. Frenzel, M., Krolak, E., Wagner, A.E., and Steffen-Heins, A., Physicochemical Properties of WPI Coated Liposomes Serving as Stable Transporters in a Real Food Matrix, Lebensmmittel-Wissen schaft Technol., vol. 63, no. 1, pp. 527-534, 2015.

  27. Gokce, E.H., Korkmaz, E., Tuncay-Tanriverdi, S., Dellera, E., Sandri, G., Bonferoni, M.C., and Ozer, O., A Comparative Evaluation of Coenzyme Q10-Loaded Liposomes and Solid-Lipid Nanoparticles as Dermal Antioxidant Carriers, Int. J. Nanomed., vol. 7, pp. 5109-5117, 2012.

  28. Gong, Y., Wu, Y., Zheng, C., Fan, L., Xiong, F., and Zhu, J., An Excellent Delivery System for Improving the Oral Bioavailability of Natural Vitamin E in Rats, AAPS Pharm. Sci. Technol., vol. 13, no. 3, pp. 961-966, 2012.

  29. Gonnet, M., Lethuaut, L., and Boury, F., New Trends in Encapsulation of Liposoluble Vitamins, J. Control Release, vol. 146, no. 3, pp. 276-290, 2010.

  30. Gregoriadis, G., Ed., Liposome Technology: Interactions of Liposomes with the Biological Milieu, vol. 3, Boca Raton, FL: CRC Press, 2006.

  31. Hatanaka, J., Chikamori, H., Sato, H., Uchida, S., Debari, K., Onoue, S., and Yamada, S., Physico-chemical and Pharmacological Characterization of a-Tocopherol-Loaded Nano-Emulsion System, Int. J. Pharm., vol. 396, no. 1, pp. 188-193, 2010.

  32. Hatcher, H., Planalp, R., Cho, J., Torti, F.M., and Torti, S.V., Curcumin: From Ancient Medicine to Current Clinical Trials, Cell Mol. Life Sci, vol. 65, no. 11, pp. 1631-1652, 2008.

  33. Huang, Y.B., Tsai, M.J., Wu, P.C., Tsai, Y.H., Wu, Y.H., and Fang, J.Y., Elastic Liposomes as Carriers for Oral Delivery and the Brain Distribution of (+)-Catechin, J. Drug Target, vol. 19, no. 8, pp. 709-718, 2011.

  34. Kamaly, N., Xiao, Z., Valencia, P.M., Radovic-Moreno, A.F., and Farokhzad, O.C., Targeted Polymeric Therapeutic Nanoparticles: Design, Development, and Clinical Translation, Chem. Soc. Rev., vol. 41, no. 7, pp. 2971-3010, 2012.

  35. Kandimalla, K.K., Babu, R.J., and Singh, M., Biphasic Flux Profiles of Melatonin: The Yin-Yang of Transdermal Permeation Enhancement Mediated by Fatty Alcohol Enhancers, J. Pharm. Sci., vol. 99, no. 1, pp. 209-218, 2010.

  36. Karadag, A., Ozcelik, B., and Huang, Q., Quercetin suspensions Produced by High-Pressure Homogenization, J. Agr. Food Chem, vol. 62, no. 8, pp. 1852-1859, 2014.

  37. Karadag, A., Yang, X., Ozcelik, B., and Huang, Q., Optimization of Preparation Conditions for Quercetin Nanoemulsions Using Response Surface Methodology, J. Agr. Food Chem., vol. 61, no. 9, pp. 2130-2139, 2013.

  38. Keller B.C., Liposomes in Nutrition, Trends Food Sci. Technol., vol. 12, no. 1, pp. 25-31, 2001.

  39. Kim, J.Y., Seo, T.R., and Lim, S.T., Preparation of Aqueous Dispersion of P-Carotene Nano-Composites through Complex Formation with Starch Dextrin, Food Hydrocolloids, vol. 33, no. 2, pp. 256-263, 2013.

  40. Kim, S.J., Cho, Y.H., Park, W., Han, D., Chai, C.H., and Imm, J.Y., Solubilization of Water Soluble Anthocyanins in Apolar Medium Using Reverse Micelle, J. Agr. Food Chem., vol. 51, no. 26, pp. 7805-7809, 2003.

  41. Kim, S.O., Ha, T.V.A., Choi, Y.J., and Ko, S., Optimization of Homogenization-Evaporation Process for Lycopene Nanoemulsion Production and Its Beverage Applications, J. Food Sci., vol. 79, no. 8, pp. N1604-N1610, 2014.

  42. Kohlmeier, L. and Hastings, S.B., Epidemiologic Evidence of a Role of Carotenoids in Cardiovascular Disease Prevention, Amer. J. Clin. Nutrition, vol. 62, no. 6, pp. 1370S-1376S, 1995.

  43. Kumar, D.T., Ghosh, S., Ghosh, M., Koley, H., and Dhar, P., Comparative Study of Gastrointestinal Absorption of EPA and DHA Rich Fish Oil from Nano and Conventional Emulsion Formulation in Rats, Food Res. Int., vol. 49, no. 1, pp. 72-79, 2012.

  44. Lacatusu, I., Mitrea, E., Badea, N., Stan, R., Oprea, O., and Meghea, A., Lipid Nanoparticles Based on Omega-3 Fatty Acids as Effective Carriers for Lutein Delivery. Preparation and In Vitro Characterization Studies, J. Funct. Food, vol. 5, no. 3, pp. 1260-1269, 2013.

  45. Lee, W.C. and Tsai, T.H., Preparation and Characterization of Liposomal Coenzyme Q10 for In Vivo Topical Application, Int. J. Pharm., vol. 395, no. 1, pp. 78-83, 2010.

  46. Letchford, K. and Burt, H., A Review of the Formation and Classification of Amphiphilic Block Co-polymer Nanoparticulate Structures: Micelles, Nanospheres, Nanocapsules, and Polymersomes, Eur. J. Pharm. Biopharm., vol. 65, no. 3, pp. 259-269, 2007.

  47. Li, Y., Zheng, J., Xiao, H., and McClements, D.J., Nanoemulsion-Based Delivery Systems for Poorly Water-Soluble Bioactive Compounds: Influence of Formulation Parameters on Polymethoxyflavone Crystallization, Food Hydrocolloids, vol. 27, no. 2, pp. 517-528, 2012.

  48. Liang, R., Shoemaker, C.F., Yang, X., Zhong, F., and Huang, Q., Stability and Bioaccessibility of P-Carotene in Nanoemulsions Stabilized by Modified Starches, J. Agr. Food Chem., vol. 61, no. 6, pp. 1249-1257, 2013.

  49. Liu, L., Tang, Y., Gao, C., Li, Y., Chen, S., Xiong, T., and Liu, L., Characterization and Biodis-tribution In Vivo of Quercetin-Loaded Cationic Nanostructured Lipid Carriers, Colloid Surface B, vol. 115, pp. 125-131, 2014.

  50. Maddi, V.S., Aragade, P.D., Digge, V.G., and Nitalikar, M.N., Importance of Nutraceuticals in Health Management, Pharmacognosy Rev., vol. 1, no. 2, p. 377, 2007.

  51. Matalanis, A., Jones, O.G., and McClements, D.J., Structured Biopolymer-Based Delivery Systems for En-capsulation, Protection, and Release of Lipophilic Compounds, Food Hydrocolloids, vol. 25, no. 8, pp. 1865-1880, 2011.

  52. McClements, D.J. and Decker, E.A., Lipid Oxidation in Oil-in-Water Emulsions: Impact of Molecular Environment on Chemical Reactions in Heterogeneous Food Systems, J. Food Sci., vol. 65, no. 8, pp. 1270-1282, 2000.

  53. McClements, D.J. and Rao J., Nanoemulsions, Food Grade: Formulation, Fabrication, Properties, Performance, Biological Fate, and Potential Toxicity, Crit. Rev. Food Sci., vol. 51, no. 4, pp. 285-330, 2011.

  54. McClements, D.J., Zou, L., Zhang, R., Salvia-Trujillo, L., Kumosani, T., and Xiao, H., Enhancing Nutraceuticals Performance Using Excipient Foods: Designing Food Structures and Compositions to Increase Bioavailability, Compr. Rev. Food Sci. F, vol. 14, no. 6, pp. 824-847, 2015.

  55. Mitri, K., Shegokar, R., Gohla, S., Anselmi, C., and Muller, R.H., Lipid Nanocarriers for Dermal Delivery of Lutein: Preparation, Characterization, Stability and Performance, Int. J. Pharm., vol. 414, no. 1, pp. 267-275, 2011.

  56. Mori, A., Lehmann, S., O'Kelly, J., Kumagai, T., Desmond, J.C., Pervan, M., and Koeffler, H.P., Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells, Cancer Res., vol. 66, no. 6, pp. 3222-3229, 2006.

  57. Muller, R.H. and Runge, S.A., Solid-Lipid Nanoparticles (SLN) for Controlled Drug Delivery, in S. Benita, Ed., Submicron Emulsions in Drug Targeting and Delivery, Amsterdam: Harwood Academic Publishers, pp. 219-234, 1998.

  58. Musthaba, S.M., Baboota, S., Ahmed, S., Ahuja, A., and Ali, J., Status of Novel Drug Delivery Technology for Phytotherapeutics, Expert Opinion Drug Del., vol. 6, no. 6, pp. 625-637, 2009.

  59. Nagle, D.G., Ferreira, D., and Zhou, Y.D., Epigallocatechin-3-Gallate (EGCG): Chemical and Biomedical Perspectives, Phytochemistry, vol. 67, no. 17, pp. 1849-1855, 2006.

  60. Naksuriya, O., Okonogi, S., Schiffelers, R.M., and Hennink, W.E., Curcumin Nanoformulations: A Review of Pharmaceutical Properties and Preclinical Studies and Clinical Data Related to Cancer Treatment, Biomaterials, vol. 35, no. 10, pp. 3365-3383, 2014.

  61. Nelson, N.J., Purple Carrots, Margarine Laced with Wood Pulp? Nutraceuticals Move into the Supermarket, JNCIJ. Natl. Cancer Inst, vol. 91, no. 9, pp. 755-757, 1999.

  62. Nutraceuticals Market (Functional Food, Dietary Supplements, Dietary Supplements, Personal Care and Pharmaceuticals) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2015-2021, 2015.

  63. Nutraceuticals Product Market: Asia Pacific Market Size, Segment and Country Analysis and Fore-casts (2007-2017), accessed from http://www.transparencymarketresearch.com/global-nutraceuticals-product-market.html, 2012.

  64. Orive, G., Hernandez, R.M., Gascon, A.R., Dominguez-Gil, A., and Pedraz, J.L., Drug Delivery in Biotechnology: Present and Future, Current Opinion Biotechnol., vol. 14, no. 6, pp. 659-664, 2003.

  65. Padamwar, M.N. and Pokharkar, V.B., Development of Vitamin Loaded Topical Liposomal Formulation Using Factorial Design Approach: Drug Deposition and Stability, Int. J. Pharm., vol. 320, no. 1, pp. 37-44, 2006.

  66. Paliyath, G., Bakovic, M., and Shetty, K., Eds., Functional Foods, Nutraceuticals, and Degenerative Disease Prevention, Oxford, UK: Wiley-Blackwell, 2011.

  67. Pandita, D., Kumar, S., Poonia, N., and Lather, V., Solid-Lipid Nanoparticles Enhance Oral Bioavailability of Resveratrol, a Natural Polyphenol, Food Res. Int., vol. 62, pp. 1165-1174, 2014.

  68. Paramera, E.I., Konteles, S.J., and Karathanos, V.T., Stability and Release Properties of Curcumin Encapsulated in Saccharomyces cerevisiae, P-Cyclodextrin and Modified Starch, Food Chem., vol. 125, no. 3, pp. 913-922, 2011.

  69. Pardeshi, C., Rajput, P., Belgamwar, V., Tekade, A., Patil, G., Chaudhary, K., and Sonje, A., Solid-Lipid Based Nanocarriers: An Overview/Nanonosacinabazicvrstihlipida: Pregled, Acta Pharmaceutica, vol. 62, no. 4, pp. 433-472, 2012.

  70. Parveen, R., Baboota, S., Ali, J., Ahuja, A., Vasudev, S.S., and Ahmad, S., Oil Based Nanocarrier for Improved Oral Delivery of Silymarin: In Vitro and In Vivo Studies, Int. J. Pharm., vol. 413, no. 1, pp. 245-253, 2011.

  71. Patel, A.R. and Velikov, K.P., Colloidal Delivery Systems in Foods: A General Comparison with Oral Drug Delivery, LWT-Food Sci. Technol, vol. 44, no. 9, pp. 1958-1964, 2011.

  72. Patel, A.R., Heussen, P.C., Hazekamp, J., Drost, E., and Velikov, K.P., Quercetin Loaded Biopolymeric Colloidal Particles Prepared by Simultaneous Precipitation of Quercetin with Hydrophobic Protein in Aqueous Medium, Food Chem., vol. 133, no. 2, pp. 423-429, 2012.

  73. Patravale, V.B. and Kulkarni, R.M., Nanosuspensions: A Promising Drug Delivery Strategy, J. Pharm. Pharmacol., vol. 56, no. 7, pp. 827-840, 2004.

  74. Pinheiro, A.C., Lad, M., Silva, H.D., Coimbra, M.A., Boland, M., and Vicente, A.A., Unravelling the Behaviour of Curcumin Nanoemulsions during In Vitro Digestion: Effect of the Surface Charge, Soft Matter, vol. 9, no. 11, pp. 3147-3154, 2013.

  75. Pitha, J., Enhanced Water Solubility of Vitamins A, D, E, and K by Substituted Cycloamyloses, Life Sci, vol. 29, no. 3, pp. 307-311, 1981.

  76. Qadir, A., Faiyazuddin, M.D., Hussain, M.T., Alshammari, T.M., and Shakeel, F., Critical Steps and Energetics Involved in a Successful Development of a Stable Nanoemulsion, J. Mol. Liq., vol. 214, pp. 7-18, 2016.

  77. Qian, C., and McClements, D.J., Formation of Nanoemulsions Stabilized by Model Food-Grade Emulsifiers Using High-Pressure Homogenization: Factors Affecting Particle Size, Food Hydrocolloids, vol. 25, no. 5, pp. 1000-1008, 2011.

  78. Qian, C., Decker, E.A., Xiao, H., and McClements, D.J., Nanoemulsion Delivery Systems: Influence of Carrier Oil on P-Carotene Bioaccessibility, Food Chem., vol. 135, no. 3, pp. 1440-1447, 2012.

  79. Qian, C., Decker, E.A., Xiao, H., and McClements, D.J., Impact of Lipid Nanoparticle Physical State on Particle Aggregation and P-Carotene Degradation: Potential Limitations of Solid-Lipid Nanoparticles, Food Res. Int., vol. 52, no. 1, pp. 342-349, 2013.

  80. Quinones, J.P., Gothelf, K.V., Kjems, J., Yang, C., Caballero, A.M.H., Schmidt, C., and Covas, C.P., Self-Assembled Nanoparticles of Modified-Chitosan Conjugates for the Sustained Release of dl-a-Tocopherol, Carbohyd. Polym., vol. 92, no. 1, pp. 856-864, 2013.

  81. Rabinow, B.E., Nanosuspensions in Drug Delivery, Nat. Rev. Drug Discovery, vol. 3, no. 9, pp. 785-796, 2004.

  82. Rachmawati, H., Shaal, L.A., Muller, R.H., and Keck, C.M., Development of Curcumin Nanocrystal: Physical Aspects, J. Pharm. Sci, vol. 102, no. 1, pp. 204-214, 2013.

  83. Rissanen, T.H., Voutilainen, S., Virtanen, J.K., Venho, B., Vanharanta, M., Mursu, J., and Salonen, J.T., Low Intake of Fruits, Berries and Vegetables is Associated with Excess Mortality in Men: The Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study, J. Nutr., vol. 133, no. 1, pp. 199-204, 2003.

  84. Rozner, S., Shalev, D.E., Shames, A.I., Ottaviani, M.F., Aserin, A., and Garti, N., Do Food Microemulsions and Dietary Mixed Micelles Interact?, Colloid Surface B, vol. 77, no. 1, pp. 22-30, 2010.

  85. Sahu, A., Kasoju, N., and Bora, U., Fluorescence Study of the Curcumin-Casein Micelle Complexation and Its Application as a Drug Nanocarrier to Cancer Cells, Biomacromolecules, vol. 9, no. 10, pp. 2905-2912, 2008.

  86. Salminen, H., Aulbach, S., Leuenberger, B.H., Tedeschi, C., and Weiss, J., Influence of Surfactant Composition on Physical and Oxidative Stability of Quillajasaponin-Stabilized Lipid Particles with Encapsulated ro-3 Fish Oil, Colloid Surface B, vol. 122, pp. 46-55, 2014.

  87. Salvia-Trujillo, L., Decker, E.A., and McClements, D.J., Influence of an Anionic Polysaccharide on the Physical and Oxidative Stability of Omega-3 Nanoemulsions: Antioxidant Effects of Alginate, Food Hydrocolloids, vol. 52, pp. 690-698, 2016.

  88. Salvia-Trujillo, L., Qian, C., Martin-Belloso, O., and McClements, D.J., Influence of Particle Size on Lipid Digestion and P-Carotene Bioaccessibility in Emulsions and Nanoemulsions, Food Chem., vol. 141, no. 2, pp. 1472-1480, 2013.

  89. Sekhon, B.S., Food Nanotechnology - An Overview, Nanotechnol., Sci. Appl., vol. 3, no. 1, pp. 1-15, 2010.

  90. Semo, E., Kesselman, E., Danino, D., and Livney, Y.D., Casein Micelle as a Natural Nano-Capsular Vehicle for Nutraceuticals, Food Hydrocolloids, vol. 21, no. 5, pp. 936-942, 2007.

  91. Sessa, M., Balestrieri, M.L., Ferrari, G., Servillo, L., Castaldo, D., D'Onofrio, N., and Tsao, R., Bioavailability of Encapsulated Resveratrol into Nanoemulsion-Based Delivery Systems, Food Chem, vol. 147, pp. 42-50, 2014.

  92. Sessa, M., Tsao, R., Liu, R., Ferrari, G., and Donsi, F., Evaluation of the Stability and Antioxidant Activity of Nanoencapsulated Resveratrol during In Vitro Digestion, J. Agr. Food Chem., vol. 59, no. 23, pp. 12352-12360, 2011.

  93. Shafiq, S., Shakeel, F., Talegaonkar, S., Ahmad, F.J., Khar, R.K., and Ali, M., Development and Bioavailability Assessment of Ramipril Nanoemulsion Formulation, Eur. J. Pharm. Biopharm., vol. 66, no. 2, pp. 227-243, 2007.

  94. Shakeel, F., Shafiq, S., Haq, N., Alanazi, F.K., and Alsarra, I.A., Nanoemulsions as Potential Vehicles for Transdermal and Dermal Delivery of Hydrophobic Compounds: An Overview, Expert Opinion Drug Delivery, vol. 9, no. 8, pp. 953-974, 2012.

  95. Shin, G.H., Chung, S.K., Kim, J.T., Joung, H.J., and Park, H.J., Preparation of Chitosan-Coated Nanoliposomes for Improving the Mucoadhesive Property of Curcumin Using the Ethanol Injection Method, J. Agr. Food Chem, vol. 61, no. 46, pp. 11119-11126, 2013.

  96. Shpigelman, A., Israeli, G., and Livney, Y.D., Thermally-Induced Protein-Polyphenol Co-Assemblies: Beta Lactoglobulin-Based Nanocomplexes as Protective Nanovehicles for EGCG, Food Hydrocolloids, vol. 24, no. 8, pp. 735-743, 2010.

  97. Soppimath, K.S., Aminabhavi, T.M., Kulkarni, A.R., and Rudzinski, W.E., Biodegradable Polymeric Nanoparticles as Drug Delivery Devices, J. Control Release, vol. 70, no. 1, pp. 1-20, 2001.

  98. Stegemann, S., Leveiller, F., Franchi, D., De Jong, H., and Linden, H., When Poor Solubility Becomes an Issue: From Early Stage to Proof of Concept, Eur. J. Pharm. Sci., vol. 31, no. 5, pp. 249-261, 2007.

  99. Sun, J., Bi, C., Chan, H.M., Sun, S., Zhang, Q., and Zheng, Y., Curcumin-Loaded Solid-Lipid Nanoparticles Have Prolonged In Vitro Antitumour Activity, Cellular Uptake and Improved In Vivo Bioavailability, Colloid Surface B, vol. 111, pp. 367-375, 2013.

  100. Takahashi, M., Uechi, S., Takara, K., Asikin, Y., and Wada, K., Evaluation of an Oral Carrier System in Rats: Bioavailability and Antioxidant Properties of Liposome-Encapsulated Curcumin, J. Agr. Food Chem, vol. 57, no. 19, pp. 9141-9146, 2009.

  101. Tan, B.J., Liu, Y., Chang, K.L., Lim, B.K., and Chiu, G.N., Perorally Active Nanomicellar Formulation of Quercetin in the Treatment of Lung Cancer, Int. J. Nanomed., vol. 7, no. 6, pp. 651-661, 2012.

  102. Tan, C., Zhang, Y., Abbas, S., Feng, B., Zhang, X., and Xia, S., Modulation of the Carotenoid Bioaccessibility through Liposomal Encapsulation, Colloid Surface B, vol. 123, pp. 692-700, 2014.

  103. Taylor, T.M., Weiss, J., Davidson, P.M., and Bruce, B.D., Liposomal Nanocapsules in Food Science and Agriculture, Crit. Rev. Food Sci., vol. 45, nos. 7-8, pp. 587-605, 2005.

  104. Turchiuli, C., Fuchs, M., Bohin, M., Cuvelier, M.E., Ordonnaud, C., Peyrat-Maillard, M.N., and Dumoulin, E., Oil Encapsulation by Spray Drying and Fluidised Bed Agglomeration, Innov. Food Sci. Emerg., vol. 6, no. 1, pp. 29-35, 2005.

  105. Velikov, K.P. and Pelan, E., Colloidal Delivery Systems for Micronutrients and Nutraceuticals, Soft Matter, vol. 4, no. 10, pp. 1964-1980, 2008.

  106. Walker, R., Decker, E.A., and McClements, D.J., Development of Food-Grade Nanoemulsions and Emulsions for Delivery of Omega-3 Fatty Acids: Opportunities and Obstacles in the Food Industry, Food Funct, vol. 6, no. 1, pp. 41-54, 2015.

  107. Wang, Y., Ma, Y., Zheng, Y., Song, J., Yang, X., Bi, C., and Zhang, Q., In Vitro and In Vivo Anticancer Activity of a Novel Puerarin Nanosuspension against Colon Cancer with High Efficacy and Low Toxicity, Int. J. Pharm., vol. 441, no. 1, pp. 728-735, 2013.

  108. Wood, R.J., Bioavailability, in Encyclopedia of Human Nutrition, L. Allen and A. Prentice, Eds., Massachusetts: Academic Press, pp. 195-201, 2005.

  109. Wydro, P., Krajewska, B., and Hac-Wydro, K., Chitosan as a Lipid Binder: A Langmuir Monolayer Study of Chitosan-Lipid Interactions, Biomacromolecules, vol. 8, no. 8, pp. 2611-2617, 2007.

  110. Xie, X., Tao, Q., Zou, Y., Zhang, F., Guo, M., Wang, Y., and Yu, S., PLGA Nanoparticles Improve the Oral Bioavailability of Curcumin in Rats: Characterizations and Mechanisms, J. Agr. Food Chem, vol. 59, no. 17, pp. 9280-9289, 2011.

  111. Yang, K., Pyo, J., Kim, G.Y., Yu, R., Ju, S., Kim, W., and Kim, B.S., Capsaicin Induces Apoptosis by Generating Reactive Oxygen Species and Disrupting Mitochondrial Transmembrane Potential in Human Colon Cancer Cell Lines, Cell. Mol. Biol. Lett, vol. 14, no. 3, pp. 497-510, 2009.

  112. Yang, S., Zhu, J., Lu, Y., Liang, B., and Yang, C., Body Distribution of Camptothecin Solid-Lipid Nanoparticles after Oral Administration, Pharm. Res., vol. 16, no. 5, pp. 751-757, 1999.

  113. Yen, F.L., Wu, T.H., Lin, L.T., Cham, T.M., and Lin, C.C., Naringenin-Loaded Nanoparticles Improve the Physicochemical Properties and the Hepatoprotective Effects of Naringenin in Orally-Administered Rats with CCl4-Induced Acute Liver Failure, Pharm. Res., vol. 26, no. 4, pp. 893-902, 2009.

  114. Yen, F.L., Wu, T.H., Lin, L.T., Cham, T.M., and Lin, C.C., Nanoparticles Formulation of Cuscuta-chinensis Prevents Acetaminophen-Induced Hepatotoxicity in Rats, Food Chem. Toxicol., vol. 46, no. 5, pp. 1771-1777, 2008.

  115. Yoo, J., Baskaran, R., and Yoo, B.K., Self-Nanoemulsifying Drug Delivery System of Lutein: Physicochemical Properties and Effect on Bioavailability of Warfarin, Biomol. Ther., vol. 21, no. 2, p. 173, 2013.

  116. Yu, A., Wang, H., Wang, J., Cao, F., Gao, Y., Cui, J., and Zhai, G., Formulation Optimization and Bioavailability after Oral and Nasal Administration in Rabbits of Puerarin-Loaded Microemulsion, J. Pharm. Sci., vol. 100, no. 3, pp. 933-941, 2011.

  117. Yu, H. and Huang, Q., Improving the Oral Bioavailability of Curcumin Using Novel Organogel- Based Nanoemulsions, J. Agr. Food Chem., vol. 60, no. 21, pp. 5373-5379, 2012.

  118. Zaki, N.M., Strategies for Oral Delivery and Mitochondrial Targeting of CoQ10, Drug Delivery, pp. 1-14, 2014.

  119. Zhang, L., Hayes, D.G., Chen, G., and Zhong, Q., Transparent Dispersions of Milk-Fat-Based Nano structured Lipid Carriers for Delivery of P-Carotene, J. Agr. Food Chem., vol. 61, no. 39, pp. 9435-9443, 2013.

  120. Zhao, L., Du, J., Duan, Y., Zhang, H., Yang, C., Cao, F., and Zhai, G., Curcumin Loaded Mixed Micelles Composed of Pluronic P123 and F68: Preparation, Optimization and In Vitro Characterization, Colloid Surface B, vol. 97, pp. 101-108, 2012.

  121. Zhou, H., Liu, G., Zhang, J., Sun, N., Duan, M., Yan, Z., and Xia, Q., Novel Lipid-Free Nanoformulation for Improving Oral Bioavailability of Coenzyme Q10, Biomed. Res. Int., 2014. DOI: 10.1155/ 2014/793879.

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