Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Neuropathological Diseases

ISSN Imprimir: 2160-2468
ISSN On-line: 2160-2476

Archives: Volume 1, 2012 to Volume 2, 2013

Neuropathological Diseases

DOI: 10.1615/NeuropatholDiseases.v1.i2.10
pages 95-122

An Overview of Parkinson's Disease and Oxidative Stress: Herbal Scenario

Richard L. Jayaraj
Department of Biotechnology, Periyar University, Tamilnadu, India
D. John Ravindar
Department of Biotechnology, Periyar University, Tamilnadu, India
K. Manigandan
Department of Biotechnology, Periyar University, Tamilnadu, India
Pavan Kumar Padarthi
Department of Biotechnology, Periyar University, Tamilnadu, India
Elangovan Namasivayam
Department of Biotechnology, Periyar University, Tamilnadu, India

RESUMO

The prevalence of Parkinson's disease (PD), the second most common neurodegenerative disorder, is increasing day by day and poses a great threat to the elderly population. Its main neuropathological feature is the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). However, the pathogenesis of PD is not understood fully. Clinical, experimental, microanatomic, and biochemical evidence suggest PD involves multifactorial oxidative neurodegeneration. The SNpc is uniquely vulnerable to oxidative damage, having a high content of oxidizable dopamine, neuromelanin, polyunsaturated fatty acids, and iron, and relatively low antioxidant complement with high metabolic rate. The aim of this review is to bring out the incidence of PD in India compared to that of Europe. Since ancient times plants have been valued for their medicinal properties, and many cultures still rely on plants as their major source of medicine. In this review we discuss the role of Indian medicinal plants in countering free-radical damage and also give you a glimpse about the clinical and pathological features of PD, available treatments, their drawbacks, and future challenges to overcome PD.


Articles with similar content:

Probing Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes): A Bitter Mushroom with Amazing Health Benefits
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 2
Robinka Khajuria, Anil Kumar Sharma, Priya Batra
The Merit of Medicinal Mushrooms from a Pharmaceutical Point of View
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 6
Ulrike Lindequist
Cinnamomum zeylanicum (Darchini): A Boon to Medical Science and a Possible Therapy for Stress-Induced Ailments
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 3
Zulfia Hussain, Haroon Rashid, Junaid Ali Khan
The Mechanisms of Dietary Phytoestrogen as a Potential Treatment and Prevention Agent against Alzheimer’s Disease
Critical Reviews™ in Eukaryotic Gene Expression, Vol.28, 2018, issue 4
Azhar Hussain, Elsa S. Tabrez, Jagannadha Rao Peela, Adil Muhammad
Hypocholesterolemic Effect of the Oyster Mushroom, Pleurotus ostreatus (Jacq.:Fr.) P. Kumm. and Its Isolated Polysaccharides
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Ayman S. Daba