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Journal of Long-Term Effects of Medical Implants

Publicou 4 edições por ano

ISSN Imprimir: 1050-6934

ISSN On-line: 1940-4379

SJR: 0.184 SNIP: 0.485 CiteScore™:: 1.1 H-Index: 39

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The Role of Macrophages in the Biological Reaction to Wear Debris from Artificial Joints

Volume 26, Edição 4, 2016, pp. 303-309
DOI: 10.1615/JLongTermEffMedImplants.2017011287
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RESUMO

Normal usage of total joint replacements results in the production of wear debris and other byproducts. In particular, polyethylene particles are heavily involved in the stimulation of local and systemic biological reactions resulting in chronic inflammation, periprosthetic bone resorption (osteolysis), and eventually implant loosening. As sentinels of the innate immune system, cells of the monocyte/macrophage lineage initiate the inflammatory cascade that lead to osteolysis. The biological processes involved are complex, based on the unique properties of the monocytes/macrophages, including sensing, chemotaxis, phagocytosis, and adaptive stimulation. The interaction with wear debris triggers the release of pro-inflammatory factors such as tumor necrosis factor-α, interleukin-1, and others; pro-osteoclastic factors such as RANKL; and chemokines such as MCP-1 and MIP-1, all of which are crucial to the recruitment, migration, differentiation, and ultimately activation of bone-resorbing osteoclasts. In parallel, other distinct macrophage populations inhibit inflammation and mitigate its consequences on the bone–implant interface. Here, the role of the monocyte/macrophage cell lineage in the initiation and maintenance of the host inflammatory response to wear debris and subsequent periprosthetic osteolysis is presented.

CITADO POR
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  2. Goodman Stuart B., Pajarinen Jukka, Yao Zhenyu, Lin Tzuhua, Inflammation and Bone Repair: From Particle Disease to Tissue Regeneration, Frontiers in Bioengineering and Biotechnology, 7, 2019. Crossref

  3. Alippe Yael, Mbalaviele Gabriel, Omnipresence of inflammasome activities in inflammatory bone diseases, Seminars in Immunopathology, 41, 5, 2019. Crossref

  4. Borm Paul J.A., The parallels between particle induced lung overload and particle induced periprosthetic osteolysis (PPOL), Open Research Europe, 1, 2021. Crossref

  5. Goodman Stuart B., Gibon Emmanuel, Gallo Jiri, Takagi Michiaki, Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis, Current Osteoporosis Reports, 20, 1, 2022. Crossref

  6. Borm Paul J.A., The parallels between particle induced lung overload and particle induced periprosthetic osteolysis (PPOL), Open Research Europe, 1, 2022. Crossref

  7. Wahl Peter, Mossu-Haas Christine, Dommann-Scherrer Corina, Wei Kongchang, Eschbach Lukas, Gehr Peter, Benninger Emanuel, Early failure of a highly cross-linked polyethylene inlay after total hip arthroplasty probably due to insufficient irradiation, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 236, 12, 2022. Crossref

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