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Journal of Long-Term Effects of Medical Implants

Publicou 4 edições por ano

ISSN Imprimir: 1050-6934

ISSN On-line: 1940-4379

SJR: 0.184 SNIP: 0.485 CiteScore™:: 1.1 H-Index: 39

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Calcium Sulfate: A Review

Volume 15, Edição 6, 2005, pp. 599-607
DOI: 10.1615/JLongTermEffMedImplants.v15.i6.30
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RESUMO

Calcium sulfate has a long history of use in medicine and dentistry. It exists in two forms (α and β), which differ greatly in physical properties. It has been used in bone regeneration as a graft material and graft binder/extender and as a barrier in guided tissue regeneration. It is an unusually biocompatible material and is completely resorbed following implantation. It does not evoke a significant host response and creates a calcium-rich milieu in the area of implantation. These calcium ions may provide some stimulation to osteoblasts, which may account for some of the positive results reported with the material. Calcium sulfate can be used as a delivery vehicle for growth factors and antibiotics, although this application has not been thoroughly exploited in the clinical setting. It has been shown that tissue will often migrate over calcium sulfate if primary closure cannot be obtained, which provides further evidence of its biocompatibility. The raw material from which calcium sulfate is made is relatively inexpensive and abundant. Despite these advantages, calcium sulfate has never attracted the same degree of research interest as have other biomaterials. Recently, however, it has enjoyed a resurgence of sorts in the areas of periodontology, sinus augmentation, and orthopedic surgery. Future research must be directed toward improving handling characteristics and strength, while preserving the biocompatibility of the material.

CITADO POR
  1. Park Andrew G., Paglia David N., Al-Zube Loay, Hreha Jeremy, Vaidya Swaroopa, Breitbart Eric, Benevenia Joseph, O'Connor J. Patrick, Lin Sheldon S., Local insulin therapy affects fracture healing in a rat model, Journal of Orthopaedic Research, 31, 5, 2013. Crossref

  2. AlGhamdi Ali Saad Thafeed, Osteotome Maxillary Sinus Lift Using Bovine Bone and Calcium Sulfate: A Case Series, Clinical Implant Dentistry and Related Research, 15, 2, 2013. Crossref

  3. Orellana Bryan R., Thomas Mark V., Dziubla Thomas D., Shah Nihar M., Hilt J. Zach, Puleo David A., Bioerodible calcium sulfate/poly(β-amino ester) hydrogel composites, Journal of the Mechanical Behavior of Biomedical Materials, 26, 2013. Crossref

  4. von Rechenberg Brigitte, Génot Oliver R., Nuss Katja, Galuppo Larry, Fulmer Mark, Jacobson Evan, Kronen Peter, Zlinszky Kati, Auer Jörg A., Evaluation of four biodegradable, injectable bone cements in an experimental drill hole model in sheep, European Journal of Pharmaceutics and Biopharmaceutics, 85, 1, 2013. Crossref

  5. Webb Nathan D., McCanless Jonathan D., Courtney Harry S., Bumgardner Joel D., Haggard Warren O., Daptomycin Eluted From Calcium Sulfate Appears Effective Against Staphylococcus, Clinical Orthopaedics & Related Research, 466, 6, 2008. Crossref

  6. Cui Xu, Zhao Dewei, Zhang Boxun, Gao Yongliang, Osteogenesis Mechanism of Chitosan-Coated Calcium Sulfate Pellets on the Restoration of Segmental Bone Defects, Journal of Craniofacial Surgery, 20, 5, 2009. Crossref

  7. Chang Kai-Chun, Chang Chia-Chieh, Chen Wei-Tang, Hsu Chung-King, Lin Feng-Huei, Lin Chun-Pin, Development of calcium phosphate/sulfate biphasic cement for vital pulp therapy, Dental Materials, 30, 12, 2014. Crossref

  8. Orellana Bryan R., Puleo David A., Tailored sequential drug release from bilayered calcium sulfate composites, Materials Science and Engineering: C, 43, 2014. Crossref

  9. Woo Kyung Mi, Yu Bin, Jung Hong-Moon, Lee Yong-Keun, Comparative evaluation of different crystal-structured calcium sulfates as bone-filling materials, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 91B, 2, 2009. Crossref

  10. Orellana Bryan R., Hilt J. Zach, Puleo David A., Drug release from calcium sulfate-based composites, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 103, 1, 2015. Crossref

  11. Reynolds Mark A., Aichelmann-Reidy Mary E., Kassolis James D., Prasad Hari S., Rohrer Michael D., Calcium sulfate–carboxymethylcellulose bone graft binder: Histologic and morphometric evaluation in a critical size defect, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 83B, 2, 2007. Crossref

  12. Beuerlein Murray J S, McKee Michael D, Calcium Sulfates: What Is the Evidence?, Journal of Orthopaedic Trauma, 24, Supplement 1, 2010. Crossref

  13. Chen Hua, Cui Xu, Yu Xuezhong, Tian XueZhong, Zhang BoXun, Tang Peifu, Wang Yan, Effects of Chitosan-Coated Pressed Calcium Sulfate Pellets Combined With Recombinant Human Bone Morphogenetic Protein 2 on Bone Formation in Femoral Condyle-Contained Bone Defects, Journal of Craniofacial Surgery, 21, 1, 2010. Crossref

  14. Madhumathi K, Sampath Kumar T S, Regenerative potential and anti-bacterial activity of tetracycline loaded apatitic nanocarriers for the treatment of periodontitis, Biomedical Materials, 9, 3, 2014. Crossref

  15. Leventis Minas D., Fairbairn Peter, Dontas Ismene, Faratzis Gregory, Valavanis Konstantinos D., Khaldi Lubna, Kostakis George, Eleftheriadis Efstathios, Biological Response to β-Tricalcium Phosphate/Calcium Sulfate Synthetic Graft Material, Implant Dentistry, 23, 1, 2014. Crossref

  16. Goh Yi-Fan, Akram Muhammad, Alshemary Ammar Z., Hussain Rafaqat, Synthesis, characterization and in vitro study of magnetic biphasic calcium sulfate-bioactive glass, Materials Science and Engineering: C, 53, 2015. Crossref

  17. Ishikawa K., Bioactive Ceramics: Cements, in Comprehensive Biomaterials, 2011. Crossref

  18. Hwang Debby, Sonick Michael, Guided Bone Regeneration: Concepts and Materials, in Implant Site Development, 2015. Crossref

  19. Han Xue, Wu Xia, Liu Hongchen, Wang Dongsheng, E Lingling, Zhou Wei, Ectopic osteogenesis of an injectable nHAC/CSH loaded with blood-acquired mesenchymal progenitor cells in a nude mice model, Journal of Materials Science: Materials in Medicine, 26, 1, 2015. Crossref

  20. Kuo Tzong-fu, Lee Sheng-Yang, Wu Hong-Da, Poma Malosi, Wu Yu-Wei, Yang Jen-Chang, An in vivo swine study for xeno-grafts of calcium sulfate-based bone grafts with human dental pulp stem cells (hDPSCs), Materials Science and Engineering: C, 50, 2015. Crossref

  21. Lyles M.B., Hu J.C., Varanasi V.G., Hollinger J.O., Athanasiou K.A., Bone tissue engineering, in Regenerative Engineering of Musculoskeletal Tissues and Interfaces, 2015. Crossref

  22. Kanellakopoulou Kyriaki, Galanopoulos Ilias, Soranoglou Vassilios, Tsaganos Thomas, Tziortzioti Vassiliki, Maris Ioannis, Papalois Apostolos, Giamarellou Helen, Giamarellos-Bourboulis Evangelos J., Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a synthetic carrier of calcium sulphate (Stimulan®) releasing moxifloxacin, International Journal of Antimicrobial Agents, 33, 4, 2009. Crossref

  23. Park Young Bum, Mohan Kathiravan, Al-Sanousi Abdulazi, Almaghrabi Bandar, Genco Robert J, Swihart Mark T, Dziak Rosemary, Synthesis and characterization of nanocrystalline calcium sulfate for use in osseous regeneration, Biomedical Materials, 6, 5, 2011. Crossref

  24. Tiwana Paul S., Kushner George M., Haug Richard H., Maxillary Sinus Augmentation, Dental Clinics of North America, 50, 3, 2006. Crossref

  25. Luo Shanchao, Jiang Tongmeng, Yang Yingnian, Yang Xiaoping, Zhao Jinmin, Combination therapy with vancomycin-loaded calcium sulfate and vancomycin-loaded PMMA in the treatment of chronic osteomyelitis, BMC Musculoskeletal Disorders, 17, 1, 2016. Crossref

  26. Chen Yirong, Zhou Yilin, Yang Shenyu, Li Jiao Jiao, Li Xue, Ma Yunfei, Hou Yilong, Jiang Nan, Xu Changpeng, Zhang Sheng, Zeng Rong, Tu Mei, Yu Bin, Novel bone substitute composed of chitosan and strontium-doped α-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility, Materials Science and Engineering: C, 66, 2016. Crossref

  27. Larrañeta Eneko, Lutton Rebecca E.M., Woolfson A. David, Donnelly Ryan F., Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development, Materials Science and Engineering: R: Reports, 104, 2016. Crossref

  28. Ishikawa K., 1.17 Bioactive Ceramics: Cements ☆, in Comprehensive Biomaterials II, 2017. Crossref

  29. Pardiñas López Simón, Anitua Eduardo, Alkhraisat Mohammad H., Pre-Implant Reconstructive Surgery, in Evidence-Based Implant Dentistry, 2016. Crossref

  30. Wu Chang-Chin, Huang Yang-Kai, Chang Wei-Jen, Wu Yun-Ching, Wang Chen-Chie, Yang Kai-Chiang, Limitation of the antibiotic-eluting bone graft substitute: An example of gentamycin-impregnated calcium sulfate, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106, 1, 2018. Crossref

  31. Murariu Marius, Dubois Philippe, PLA composites: From production to properties, Advanced Drug Delivery Reviews, 107, 2016. Crossref

  32. Krell Ethan S., Ippolito Joseph A., Montemurro Nicholas J., Lim Phillip H., Vincent Richard A., Hreha Jeremy, Cottrell Jessica, Sudah Suleiman Y., Muñoz Maximilian F., Pacific Kristen P., Benevenia Joseph, O'Connor J. Patrick, Lin Sheldon S., Local Zinc Chloride Release From a Calcium Sulfate Carrier Enhances Fracture Healing, Journal of Orthopaedic Trauma, 31, 3, 2017. Crossref

  33. Mao Keya, Cui Fuzai, Li Jiangtao, Hao Libo, Tang Peifu, Wang Zheng, Wen Ning, Liang Maohua, Wang Jifang, Wang Yan, Preparation of combined β-TCP/α-CSH artificial bone graft and its performance in a spinal fusion model, Journal of Biomaterials Applications, 27, 1, 2012. Crossref

  34. Liu Zunpeng, Yuan Xue, Fernandes Gabriela, Dziak Rosemary, Ionita Ciprian N., Li Chunyi, Wang Changdong, Yang Shuying, The combination of nano-calcium sulfate/platelet rich plasma gel scaffold with BMP2 gene-modified mesenchymal stem cells promotes bone regeneration in rat critical-sized calvarial defects, Stem Cell Research & Therapy, 8, 1, 2017. Crossref

  35. Boyan B.D., Cohen D.J., Schwartz Z., 7.17 Bone Tissue Grafting and Tissue Engineering Concepts ☆, in Comprehensive Biomaterials II, 2017. Crossref

  36. Baino Francesco, Ceramics for bone replacement, in Advances in Ceramic Biomaterials, 2017. Crossref

  37. Asadi-Eydivand Mitra, Solati-Hashjin Mehran, Shafiei Seyedeh Sara, Mohammadi Sepideh, Hafezi Masoud, Abu Osman Noor Azuan, Burns Jorge Sans, Structure, Properties, and In Vitro Behavior of Heat-Treated Calcium Sulfate Scaffolds Fabricated by 3D Printing, PLOS ONE, 11, 3, 2016. Crossref

  38. Aldemir Dikici Betül, Dikici Serkan, Karaman Ozan, Oflaz Hakan, The effect of zinc oxide doping on mechanical and biological properties of 3D printed calcium sulfate based scaffolds, Biocybernetics and Biomedical Engineering, 37, 4, 2017. Crossref

  39. Aquino-Martínez Rubén, Angelo Alcira P., Pujol Francesc Ventura, Calcium-containing scaffolds induce bone regeneration by regulating mesenchymal stem cell differentiation and migration, Stem Cell Research & Therapy, 8, 1, 2017. Crossref

  40. Subhi Hasan, Reza Fazal, Husein Adam, Al Shehadat Saaid Ayesh, Nurul Asma-Abdullah, Gypsum-Based Material for Dental Pulp Capping: Effect of Chitosan and BMP-2 on Physical, Mechanical, and Cellular Properties, International Journal of Biomaterials, 2018, 2018. Crossref

  41. Larrañeta Eneko, Raj Singh Thakur Raghu, Microneedle Manufacturing and Testing, in Microneedles for Drug and Vaccine Delivery and Patient Monitoring, 2018. Crossref

  42. Fernandez de Grado Gabriel, Keller Laetitia, Idoux-Gillet Ysia, Wagner Quentin, Musset Anne-Marie, Benkirane-Jessel Nadia, Bornert Fabien, Offner Damien, Bone substitutes: a review of their characteristics, clinical use, and perspectives for large bone defects management, Journal of Tissue Engineering, 9, 2018. Crossref

  43. Guarino Vincenzo, Iafisco Michele, Spriano Silvia, Introducing biomaterials for tissue repair and regeneration, in Nanostructured Biomaterials for Regenerative Medicine, 2020. Crossref

  44. Baranes David, Kurtzman Gregori M., Biphasic Calcium Sulfate as an Alternative Grafting Material in Various Dental Applications, Journal of Oral Implantology, 45, 3, 2019. Crossref

  45. Meng Zhu Long, Wu Zi Quan, Shen Bi Xin, Li Hong Bo, Bian Yang Yang, Zeng De Lu, Fu Jian, Peng Lei, Reconstruction of large segmental bone defects in rabbit using the Masquelet technique with α-calcium sulfate hemihydrate, Journal of Orthopaedic Surgery and Research, 14, 1, 2019. Crossref

  46. Zhang Hao, Yang Li, Yang Xiong‐gang, Wang Feng, Feng Jiang‐tao, Hua Kun‐chi, Li Qi, Hu Yong‐cheng, Demineralized Bone Matrix Carriers and their Clinical Applications: An Overview, Orthopaedic Surgery, 11, 5, 2019. Crossref

  47. Yahav Amos, Kurtzman Gregori M., Katzap Michael, Dudek Damian, Baranes David, Bone Regeneration, Dental Clinics of North America, 64, 2, 2020. Crossref

  48. Luo Shanchao, Jiang Tongmeng, Long Lina, Yang Yingnian, Yang Xiaoping, Luo Lan, Li Jinli, Chen Zhiyu, Zou Chongqi, Luo Shixing, A dual PMMA/calcium sulfate carrier of vancomycin is more effective than PMMA‐vancomycin at inhibiting Staphylococcus aureus growth in vitro , FEBS Open Bio, 10, 4, 2020. Crossref

  49. Hasandoost Leyla, Alhalawani Adel, Rodriguez Omar, Rahimnejad Yazdi Alireza, Zalzal Paul, Schemitsch Emil H., Waldman Stephen D., Papini Marcello, Towler Mark R., Calcium sulfate‐containing glass polyalkenoate cement for revision total knee arthroplasty fixation, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108, 8, 2020. Crossref

  50. Zhu Wei, Li Wei, Chen Kaiyuan, Feng Bin, Zhou Lizhi, Weng Xisheng, Cui Sheng, Engqvist Håkan, Xia Wei, Injectable and assembled 3D solid structure for free-to-fixed shape in bone reconstruction, Applied Materials Today, 21, 2020. Crossref

  51. Wahl Peter, Rönn Karolin, Bohner Marc, Decosterd Laurent A, Meier Christoph, Schläppi Michel, Festa Sandrine, Gautier Emanuel, In vitro study of new combinations for local antibiotic therapy with calcium sulphate - Near constant release of ceftriaxone offers new treatment options, Journal of Bone and Joint Infection, 3, 4, 2018. Crossref

  52. Wang Jinwu, Xie Linzhen, Wang Xingyu, Zheng Wenhao, Chen Hua, Cai Leyi, Chen Long, The effects of oyster shell/alpha-calcium sulfate hemihydrate/platelet-rich plasma/bone mesenchymal stem cells bioengineering scaffold on rat critical-sized calvarial defects, Journal of Materials Science: Materials in Medicine, 31, 11, 2020. Crossref

  53. Vetrone Fiorenzo, Variola Fabio, Tambasco de Oliveira Paulo, Zalzal Sylvia Francis, Yi Ji-Hyun, Sam Johannes, Bombonato-Prado Karina F., Sarkissian Andranik, Perepichka Dmitrii F., Wuest James D., Rosei Federico, Nanci Antonio, Nanoscale Oxidative Patterning of Metallic Surfaces to Modulate Cell Activity and Fate, Nano Letters, 9, 2, 2009. Crossref

  54. Song Botao, Hu Gaoli, Lotus Leaf-Inspired Bone Cement Particles with Ultrahigh Drug Encapsulation Capacity, ACS Applied Bio Materials, 1, 1, 2018. Crossref

  55. Teotia Arun Kumar, Gupta Ankur, Raina Deepak Bushan, Lidgren Lars, Kumar Ashok, Gelatin-Modified Bone Substitute with Bioactive Molecules Enhance Cellular Interactions and Bone Regeneration, ACS Applied Materials & Interfaces, 8, 17, 2016. Crossref

  56. Liu Jinlong, Zhang Yicai, Qiu Lin, Zhang Yujuan, Gao Bin, Assessment of α-calcium sulfate hemihydrate/nanocellulose composite bone graft material for bone healing in a rabbit femoral condyle model, Materials Express, 11, 9, 2021. Crossref

  57. Manfredini Mattia, Poli Pier Paolo, Creminelli Luca, Porro Alberto, Maiorana Carlo, Beretta Mario, Comparative Risk of Bleeding of Anticoagulant Therapy with Vitamin K Antagonists (VKAs) and with Non-Vitamin K Antagonists in Patients Undergoing Dental Surgery, Journal of Clinical Medicine, 10, 23, 2021. Crossref

  58. Variola Fabio, Nanci Antonio, Titania Thin Films in Biocompatible Matals and Medical Implants, in Oxide Ultrathin Films, 2011. Crossref

  59. Jia Wei-Tao, Luo Shi-Hua, Zhang Chang-Qing, Wang Jian-Qiang, In Vitro and In Vivo Efficacies of Teicoplanin-Loaded Calcium Sulfate for Treatment of Chronic Methicillin-Resistant Staphylococcus aureus Osteomyelitis , Antimicrobial Agents and Chemotherapy, 54, 1, 2010. Crossref

  60. Ebrahiminejad Vahid, Prewett Philip D., Davies Graham J., Faraji Rad Zahra, Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration, Advanced Materials Interfaces, 9, 6, 2022. Crossref

  61. Amirthalingam Sivashanmugam, Lee Seunghun S., Rajendran Arun Kumar, Kim Inseon, Hwang Nathaniel S., Rangasamy Jayakumar, Addition of lactoferrin and substance P in a chitin/PLGA-CaSO4 hydrogel for regeneration of calvarial bone defects, Materials Science and Engineering: C, 126, 2021. Crossref

  62. Vallon Faustine, Meier Christoph, Gautier Emanuel, Wahl Peter, The Incidence of Severe Hypercalcaemia-Induced Mental Status Changes in Patients Treated with Antibiotic-Loaded Calcium Sulphate Depot for Orthopaedic Infections, Journal of Clinical Medicine, 11, 16, 2022. Crossref

  63. Germaini Marie-Michèle, Belhabib Sofiane, Guessasma Sofiane, Deterre Rémi, Corre Pierre, Weiss Pierre, Additive manufacturing of biomaterials for bone tissue engineering – A critical review of the state of the art and new concepts, Progress in Materials Science, 130, 2022. Crossref

  64. Chiang Chih‐Yung, Chang Wei‐Chia, Chang Wei‐Min, Shih Yin‐Chuan, Lin Feng‐Huei, Wu Chang‐Chin, Yang Kai‐Chiang, An assessment of physical properties and the viability of osteoblast‐like cells of cefazolin‐impregnated calcium sulfate bone‐void filler, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2022. Crossref

  65. Katzap Michael, Kurtzman Gregori M., Utilization of Biphasic Calcium Sulfate as Socket Preservation Grafting as a Prelude to Implant Placement: A Case Report, Journal of Oral Implantology, 48, 5, 2022. Crossref

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