Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Imprimir: 1050-6934
ISSN On-line: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v27.i2-4.60
pages 163-175

A Review on the Biomechanical Effects of Fatigue on the Porcine Bioprosthetic Heart Valve

Michael S. Sacks
Tissue Mechanics Laboratory, Department of Bioengineering, University of Pittsburgh, Room 749 Benedum Hall, 3700 Ohara St., Pittsburgh, PA 15261

RESUMO

Characterization of the mechanisms of degeneration of porcine bioprosthetic heart valves (BHV) during long-term cyclic loading is required for predicting and ultimately preventing their failure. Isolation of purely mechanical effects from host biological ones is a necessary first step in understanding the fatigue process as a whole. Thus, in this review we focus on mechanical factors alone as a means of isolating their role in altering biomechanical properties and ultimately their contribution to the fatigue damage process. Mechanical evaluations included tension controlled biaxial, 3-point flexural, and uniaxial failure tests performed on cuspal tissue following 0, 50, 100, 200, and 300 × 106 in vitro accelerated test cycles. Overall, biaxial mechanical results indicate a decreasing radial extensibility that can be explained by stiffening of the effective collagen fiber network as well as a small decrease in the splay of the collagen fibers. Moreover, these results suggest that the loss in flexural rigidity with fatigue that we have previously measured (ASAIO 1999; 45:59−63) may not be because of loss of collagen stiffness alone, but also to fiber debonding and degradation of the amorphous extracellular matrix. We discuss the implications of these results that point toward the development of chemical-treatment methods that seek to maintain the integrity of the amorphous extracellular matrix to ultimately extend BHV long-term durability.


Articles with similar content:

The Biomechanical Effects of Fatigue on the Porcine Bioprosthetic Heart Valve
Journal of Long-Term Effects of Medical Implants, Vol.11, 2001, issue 3&4
Michael S. Sacks
A Comparison of Force Sensing for Applications in Prosthetic Haptic Feedback
Critical Reviews™ in Biomedical Engineering, Vol.47, 2019, issue 2
Jinglin Liu, Megan Wieser, Priscilla Hernandez, Jeffrey T. La Belle
Application of Hydrogels in Heart Valve Tissue Engineering
Journal of Long-Term Effects of Medical Implants, Vol.25, 2015, issue 1-2
Bin Xu, Daniel S. Puperi, Xing Zhang, K. Jane Grande-Allen, Yan Wu, Jennifer L. West
Graphene Nanoplatelet-Reinforced Silicone for the Valvular Prosthesis Application
Journal of Long-Term Effects of Medical Implants, Vol.25, 2015, issue 1-2
Sharan Ramaswamy, Makensley Lordeus, Angie Estrada, Danique Stewart, Rupak Dua, Arvind Agarwal, Cheng Zhang
The Paths of Musculoskeletal Scaffold Research Leading to Long-Term Effects
Journal of Long-Term Effects of Medical Implants, Vol.22, 2012, issue 3
Fred R. T Nelson