Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Immunology
Fator do impacto: 1.352 FI de cinco anos: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472

Volumes:
Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v37.i2-6.140
pages 507-521

DNA Vaccines – A Modern Gimmick or a Boon to Vaccinology?

Elanchezhiyan Manickan
Department of Microbiology, University of Tennessee, Knoxville, TN 37996-0845
Kevin L. Karem
Department of Microbiology, University of Tennessee, Knoxville, TN 37996-0845
Barry T. Rouse
Department of Microbiology, University of Tennessee, Knoxville, TN 37996-0845

RESUMO

The reports in 1993 that naked DNA encoding viral genes conferred protective immunity came as a surprise to most vaccinologists. This review analyses the expanding number of examples where plasmid DNA induces immune responses. Issues such as the type of immunity induced, mechanisms of immune protection, and how DNA vaccines compare with other approaches are emphasized. Additional issues discussed include the likely means by which DNA vaccines induce CTL, how the potency and type of immunity induced can be modified, and whether DNA vaccines represent a practical means of manipulating unwanted immune response occurring during immunoinflammatory diseases. It seems doubtful if DNA vaccines will replace currently effective vaccines, but they may prove useful for prophylactic use against some agents that at present lack an effective vaccine. DNA vaccines promise to be valuable to manipulate the immune response in situations where responses to agents are inappropriate or ineffective.


Articles with similar content:

DNA Vaccines − A Modern Gimmick or a Boon to Vaccinology?
Critical Reviews™ in Immunology, Vol.17, 1997, issue 2
Kevin L. Karem, Barry T. Rouse, Elanchezhiyan Manickan
New Approaches to Antigen Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.17, 2000, issue 3
David FitzGerald, Randall J. Mrsny
CD1d-Mediated Antigen Presentation to Natural Killer T (NKT) Cells
Critical Reviews™ in Immunology, Vol.23, 2003, issue 5-6
Tonya J. Roberts, Venkataraman Sriram, Yinling Lin, Sungyoo Cho, Randy R. Brutkiewicz, Yu Kyeong Hwang
Mucosal Immunization: A Review of Strategies and Challenges
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.31, 2014, issue 4
Mohan N. Rathi, Hinal Patel, Chetan Yewale, Ambikanandan Misra
Immunotherapeutic Approaches for Glioma
Critical Reviews™ in Immunology, Vol.29, 2009, issue 1
Xinmei Zhu, Gary Kohanbash, Mitsugu Fujita, Aki Hoji, Ryo Ueda, Edward R. Kastenhuber, Hideho Okada