Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Immunology
Fator do impacto: 1.404 FI de cinco anos: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472

Volumes:
Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v24.i4.40
30 pages

Human High Molecular Weight-Melanoma-Associated Antigen (HMW-MAA): A Melanoma Cell Surface Chondroitin Sulfate Proteoglycan (MSCP) with Biological and Clinical Significance

Michael R. Campoli
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263
Chien-Chung Chang
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263
Toshiro Kageshita
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263
Xinhui Wang
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263
James B. McCarthy
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455
Soldano Ferrone
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263

RESUMO

The lack of effective conventional therapies for the treatment of advanced stage melanoma has stimulated interest in the application of novel strategies for the treatment of patients with malignant melanoma. Because of its expression in a large percentage of melanoma lesions and its restricted distribution in normal tissues, the high molecular weight-melanoma-associated antigen (HMW-MAA), also known as the melanoma chondroitin sulfate proteoglycan (MCSP), has been used to implement immunotherapy of melanoma. The potential clinical relevance of HMW-MAA/MCSP has stimulated investigations to characterize its structural properties and biological function in melanoma cells. Over the last 10 years, the field of HMW-MAA/MCSP research has seen tremendous growth. Specifically, a significant amount of information has been accumulated regarding (1) the structural characteristics of the HMW-MAA/MCSP, (2) its role in the biology of melanoma cells, and (3) the potential molecular mechanisms underlying the association between HMW-MAA/MCSP—specific immunity and survival prolongation in melanoma patients immunized with HMW-MAA/MCSP mimics. In this review, we summarize the characteristics of the HMW-MAA/MCSP in terms of its structure, antigenic profile, tissue distribution, and similarities with its counterparts in other animal species. Additionally, we discuss the role the HMW-MAA/MCSP plays in melanoma cell biology with emphasis on the recently identified signal transduction pathways triggered by the HMW-MAA/MCSP. Finally, we discuss the potential molecular mechanisms underlying the beneficial effect of anti-HMW-MAA/MCSP antibodies on the clinical course of the disease in patients with melanoma.


Articles with similar content:

Toward Prediction of Immune Mechanisms and Design of Immunotherapies in Melanoma
Critical Reviews™ in Biomedical Engineering, Vol.40, 2012, issue 4
Frank O. Nestle, Louise Saul, Sophia N. Karagiannis, Sophia Tsoka, Debra H. Josephs, Chrysanthi Ainali, Panagiotis Karagiannis
Tumor Hypoxia: A Key Determinant of Microenvironment Hostility and a Major Checkpoint during the Antitumor Response
Critical Reviews™ in Immunology, Vol.38, 2018, issue 6
Hussam H. Nawafleh, Stéphanie Buart, Rania Faouzi Zaarour, Stéphane Terry, Amirtharaj Francis, Prathibha Prasad, Nagwa Ahmed Zeinelabdin, Salem Chouaib, Goutham Hassan Venkatesh
Driving Cytotoxic Natural Killer Cells into Melanoma: If CCL5 Plays the Music, Autophagy Calls the Shots
Critical Reviews™ in Oncogenesis, Vol.23, 2018, issue 5-6
Muhammad Zaeem Noman, Markus Ollert, Ludovic Menard, Malina Xiao, Bassam Janji, Martyna Szpakowska, Andy Chevigne, Guy Berchem, Manon Bosseler
YY1 Is an Inducer of Cancer Metastasis
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Guangchao Sui, Dangdang Li, Wenmeng Wang
The Role of Bruton's Tyrosine Kinase in Immune Cell Signaling and Systemic Autoimmunity
Critical Reviews™ in Immunology, Vol.38, 2018, issue 1
Esmee K. Van Der Ploeg, Rudi W. Hendriks, Jasper Rip, Odilia B. J. Corneth