Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Immunology
Fator do impacto: 1.404 FI de cinco anos: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472

Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v26.i4.30
pages 317-352

Mycobacterium tuberculosis-Specific CD8+ T Cells and Their Role in Immunity

Joshua S. M. Woodworth
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115
Samuel M. Behar
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115


There are more cases of tuberculosis in the world today than at any other time in history. The global epidemic has generated intense interest into the immunological mechanisms that control infection. Although CD4+ T cells play a critical role in host immunity to Mycobacterium tuberculosis, there is considerable interest in understanding the role of other T cell subsets in preventing disease development following infection. CD8+ T cells are required for optimum host defense following M. tuberculosis infection, which has led to investigation into how this protective effect is mediated. A critical review of recent literature regarding the role of CD8+ T cells in protective immunity to M. tuberculosis infection is now required to address the strengths and weaknesses of these studies. In this article, we evaluate the evidence that CD8+ T cells are critical in immunity to M. tuberculosis infection. We discuss the specific mycobacterial proteins that are recognized by CD8+ T cells elicited during infection. Finally, we examine the effector mechanisms of CD8+ T cells generated during infection and synthesize recent studies to consider the protective roles that these T cells serve in vivo.

Articles with similar content:

Cross-Presentation of Antigens by Dendritic Cells
Critical Reviews™ in Immunology, Vol.22, 2002, issue 5-6
William R. Heath, Francis R. Carbone, Gabrielle T. Belz
Advances in the Study of CD8+ Regulatory T Cells
Critical Reviews™ in Immunology, Vol.39, 2019, issue 6
Xiaolei Tang, Vipin Kumar
Costimulation Signals for Memory CD8+ T Cells During Viral Infections
Critical Reviews™ in Immunology, Vol.29, 2009, issue 6
Peter D. Katsikis, Alina C. Boesteanu, Priyanka A. Duttagupta
Effect of Lymphodepletion on Donor T Cells and the Role of Recipient Cells Persisting after Cytotoxic Treatments in Cancer Immunotherapies
Critical Reviews™ in Immunology, Vol.37, 2017, issue 1
Toshiaki Kikuchi, Toshiyuki Koya, Masashi Arita, Miho Takahashi, Yu Saida, Satoshi Watanabe
CD4+ T Cells Orchestrate Both Amplification and Deletion of CD8+T Cells
Critical Reviews™ in Immunology, Vol.18, 1998, issue 6
Enza Piccolella, Loredana Frasca, Cinzia Piazza