Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
The Role of Chemokines in Migration of Metastatic-like Lymphangioleiomyomatosis Cells
Get access
RESUMO
Lymphangioleiomyomatosis (LAM), a rare cystic lung disease with multi-organ involvement, occurs primarily in women of childbearing age. LAM can present sporadically or in association with tuberous sclerosis complex (TSC). Loss of lung function in patients with LAM can be attributed to the dysregulated growth of LAM cells, with dysfunctional TSC1 or TSC2 genes, which encode hamartin and tuberin, respectively, leading to hyperactivation of the mammalian target of rapamycin (mTOR). LAM cells are smooth muscle-like cells that express melanoma antigens such as gp100, a splice variant of the Pmel17 gene. Tuberin and hamartin form heterodimers that act as negative regulators of mTOR. Lack of TSC2 function, as occurs in LAM cells, leads to the production of the chemokine CCL2/monocyte chemotactic protein 1 (MCP-1), which increases LAM cell mobility. Although many chemokines and their receptors could influence LAM cell mobilization, we propose that a positive-feedback loop is generated when dysfunctional TSC2 is present in LAM cells. We identified a group of chemokine receptors that is expressed in LAM cells and differs from those on smooth muscle and melanoma cells (Malme-3M). Chemokines have been implicated in tumor metastasis, and our data suggest a role for chemokines in LAM cell mobilization and thereby in the pathogenesis of LAM.
-
Siroky Brian J., Yin Hong, Bissler John J., Clinical and Molecular Insights into Tuberous Sclerosis Complex Renal Disease, Pediatric Nephrology, 26, 6, 2011. Crossref
-
Pappas Konstantinos, Bronchiolitis and bronchial disorders in interstitial lung disease, Current Opinion in Pulmonary Medicine, 17, 5, 2011. Crossref
-
Prizant Hen, Taya Manisha, Lerman Irina, Light Allison, Sen Aritro, Mitra Soumya, Foster Thomas H, Hammes Stephen R, Estrogen maintains myometrial tumors in a lymphangioleiomyomatosis model, Endocrine-Related Cancer, 23, 4, 2016. Crossref
-
Ruiz de Garibay Gorka, Herranz Carmen, Llorente Alicia, Boni Jacopo, Serra-Musach Jordi, Mateo Francesca, Aguilar Helena, Gómez-Baldó Laia, Petit Anna, Vidal August, Climent Fina, Hernández-Losa Javier, Cordero Álex, González-Suárez Eva, Sánchez-Mut José Vicente, Esteller Manel, Llatjós Roger, Varela Mar, López José Ignacio, García Nadia, Extremera Ana I., Gumà Anna, Ortega Raúl, Plà María Jesús, Fernández Adela, Pernas Sònia, Falo Catalina, Morilla Idoia, Campos Miriam, Gil Miguel, Román Antonio, Molina-Molina María, Ussetti Piedad, Laporta Rosalía, Valenzuela Claudia, Ancochea Julio, Xaubet Antoni, Casanova Álvaro, Pujana Miguel Angel, Reiner David J., Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness, PLOS ONE, 10, 7, 2015. Crossref
-
Unachukwu Uchenna, Shiomi Takayuki, Goldklang Monica, Chada Kiran, D'Armiento Jeanine, Renal neoplasms in tuberous sclerosis mice are neurocristopathies, iScience, 24, 7, 2021. Crossref
-
Cui Ye, Steagall Wendy K., Lamattina Anthony M., Pacheco-Rodriguez Gustavo, Stylianou Mario, Kidambi Pranav, Stump Benjamin, Golzarri Fernanda, Rosas Ivan O., Priolo Carmen, Henske Elizabeth P., Moss Joel, El-Chemaly Souheil, Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation, Cancer Research, 77, 6, 2017. Crossref
-
Taveira-DaSilva Angelo M., Moss Joel, Lymphangioleiomyomatosis, in Encyclopedia of Respiratory Medicine, 2022. Crossref
-
Atochina-Vasserman Elena N., Guo Chang-Jiang, Abramova Elena, Golden Thea N., Sims Michael, James Melane L., Beers Michael F., Gow Andrew J., Krymskaya Vera P., Surfactant Dysfunction and Lung Inflammation in the Female Mouse Model of Lymphangioleiomyomatosis, American Journal of Respiratory Cell and Molecular Biology, 53, 1, 2015. Crossref