Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
Indexed in
Immunopathogenesis of the Anti-Synthetase Syndrome
RESUMO
Among the inflammatory myopathies, anti-tRNA-synthetase syndrome (ASyS) is a severe autoimmune condition characterized by extramuscular involvement, affecting especially the lungs. ASyS specific serological markers are anti-tRNA-synthetase autoantibodies, among which anti-histidyl-tRNA-synthetase is the most common. In the past decades, ASyS has been distinguished by unique histological features attributed to a specific pathogenesis. Research has highlighted the role of environmental factors and infections as possible triggers. Tissue modifications of histidyl-tRNA-synthetase (HisRS) expression might be responsible for the recruitment and activation of both innate and adaptive immune cells. HisRS not only acts through antigenic properties, but also through many others, including chemoattraction, innate pathway activation, and cytokine-like functions. Favored by a certain genetic background, this whole activation of immunity results in widespread and specific tissue damage and finally leads to visible heterogeneous symptoms characterizing the disease state. Understanding the pathogenesis of ASyS is essential to improving patient care by identifying biomarkers and designing new therapeutic strategies accordingly. Therefore, this review details the recent hypotheses concerning the dynamic of ASyS pathogenesis with the aim of enlightening the development of new therapeutic axes in the future.
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Hervier Baptiste, Uzunhan Yurdagül, Inflammatory Myopathy-Related Interstitial Lung Disease: From Pathophysiology to Treatment, Frontiers in Medicine, 6, 2020. Crossref
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Preuße Corinna, Paesler Barbara, Nelke Christopher, Cengiz Derya, Müntefering Thomas, Roos Andreas, Amelin Damien, Allenbach Yves, Uruha Akinori, Dittmayer Carsten, Hentschel Andreas, Pawlitzki Marc, Hoffmann Sarah, Timm Sara, Louis Sarah Leonard, Dengler Nora F., Wiendl Heinz, Lünemann Jan D., Sickmann Albert, Hervier Baptiste, Meuth Sven G., Schneider Udo, Schänzer Anne, Krause Sabine, Tomaras Stylianos, Feist Eugen, Hasseli Rebecca, Goebel Hans-Hilmar, Gallay Laure, Streichenberger Nathalie, Benveniste Olivier, Stenzel Werner, Ruck Tobias, Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis, Acta Neuropathologica, 144, 2, 2022. Crossref