Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
Developmental Hematopoiesis
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RESUMO
Hematopoiesis is a developmental process that evolves throughout the lifespan of an individual. Most work in the field has focused on events occurring in the adult bone marrow (BM). In the embryo, blood and endothelial cell generation begins very early after gastrulation, in defined intraembryonic mesodermic sites. Recent multidisciplinary studies, taking advantage of classic embryological and gene targeting technology in various species, have provided a new image of embryofetal lymphohemopoiesis, which includes the suggestion of developmental compartmentalization or waves. The first hematopoietic stem cells (HSC) migrate further and home in an ordered sequence of supporting microenvironments depending on scarcely known molecular requirements. These early hematopoietic progenitors show important differences in their cell biology and differentiation potentialities with respect to those present in adult stages; this fact, together with specific microenvironmental influences, define a process that diverges significantly from that occurring in the BM. Here, we update the latest developments in the field, the new understanding of lymphohemopoiesis in prenatal life, and the novel questions that this emerging paradigm is producing.
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Raaphorst Frank M., Otte Arie P., van Kemenade Folkert J., Blokzijl Tjasso, Fieret Elly, Hamer Karien M., Satijn David P. E., Meijer Chris J. L. M., Distinct BMI-1 and EZH2 Expression Patterns in Thymocytes and Mature T Cells Suggest a Role for Polycomb Genes in Human T Cell Differentiation, The Journal of Immunology, 166, 10, 2001. Crossref
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Martı́nez-M. José A., Minguet Susana, Gonzalo Pilar, Soro Pilar G., de Andrés Belén, Ízcue Ana, Marcos Miguel A. R., Gaspar Marı́a-Luisa, Long-lived polyclonal B-cell lines derived from midgestation mouse embryo lymphohematopoietic progenitors reconstitute adult immunodeficient mice, Blood, 98, 6, 2001. Crossref
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de Andrés Belén, Gonzalo Pilar, Minguet Susana, Martı́nez-Marı́n José A., Soro Pilar G., Marcos Miguel Angel R., Gaspar Marı́a Luisa, The first 3 days of B-cell development in the mouse embryo, Blood, 100, 12, 2002. Crossref