Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
Indexed in
Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks
RESUMO
Ribosomal proteins have long been known to serve critical roles in facilitating the biogenesis of the ribosome and its ability to synthesize proteins. However, evidence is emerging that suggests ribosomal proteins are also capable of performing tissue-restricted, regulatory functions that impact normal development and pathological conditions, including cancer. The challenge in studying such regulatory functions is that elimination of many ribosomal proteins also disrupts ribosome biogenesis and/or function. Thus, it is difficult to determine whether developmental abnormalities resulting from ablation of a ribosomal protein result from loss of core ribosome functions or from loss of the regulatory function of the ribosomal protein. Rpl22, a ribosomal protein component of the large 60S subunit, provides insight into this conundrum; Rpl22 is dispensable for both ribosome biogenesis and protein synthesis yet its ablation causes tissue-restricted disruptions in development. Here we review evidence supporting the regulatory functions of Rpl22 and other ribosomal proteins
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Kim Stephen J., Strich Randy, Rpl22 is required for IME1 mRNA translation and meiotic induction in S. cerevisiae, Cell Division, 11, 1, 2016. Crossref
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Solanki Nehal R., Stadanlick Jason E., Zhang Yong, Duc Ann-Cecile, Lee Sang-Yun, Lauritsen Jens Peter Holst, Zhang Zhiqiang, Wiest David L., Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling, The Journal of Immunology, 197, 6, 2016. Crossref
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Tombulturk FK, Kasap M, Tuncdemir M, Polat E, Sirekbasan S, Kanli A, Kanigur-Sultuybek G, Effects of Lucilia sericata on wound healing in streptozotocin-induced diabetic rats and analysis of its secretome at the proteome level, Human & Experimental Toxicology, 37, 5, 2018. Crossref
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Boyd-Shiwarski Cary R., Shiwarski Daniel J., Roy Ankita, Namboodiri Hima N., Nkashama Lubika J., Xie Jian, McClain Kara L., Marciszyn Allison, Kleyman Thomas R., Tan Roderick J., Stolz Donna B., Puthenveedu Manojkumar A., Huang Chou-Long, Subramanya Arohan R., Barber Diane, Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent, Molecular Biology of the Cell, 29, 4, 2018. Crossref
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Das Anindhya Sundar, Basu Anandita, Kumar Ravi, Borah Pallab Kumar, Bakshi Subhojit, Sharma Manoj, Duary Raj Kumar, Ray Partho Sarothi, Mukhopadhyay Rupak, Post‐transcriptional regulation of C‐C motif chemokine ligand 2 expression by ribosomal protein L22 during LPS‐mediated inflammation, The FEBS Journal, 287, 17, 2020. Crossref
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Xiong Wei, Lan Ting, Mo Beixin, Extraribosomal Functions of Cytosolic Ribosomal Proteins in Plants, Frontiers in Plant Science, 12, 2021. Crossref
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Ren Yue, Huo Yue, Li Weiqian, He Manman, Liu Siqi, Yang Jiabin, Zhao Hongmei, Xu Lingjie, Guo Yuehong, Si Yanmin, Zhao Hualu, Rao Shuan, Wang Jing, Ma Yanni, Wang Xiaoshuang, Yu Jia, Wang Fang, A global screening identifies chromatin-enriched RNA-binding proteins and the transcriptional regulatory activity of QKI5 during monocytic differentiation, Genome Biology, 22, 1, 2021. Crossref
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Feng Zhao, Zhang Lu, Wu Yuanyuan, Wang Li, Xu Mingying, Yang Mo, Li Yajuan, Wei Gehong, Chou Minxia, The Rpf84 gene, encoding a ribosomal large subunit protein, RPL22, regulates symbiotic nodulation in Robinia pseudoacacia, Planta, 250, 6, 2019. Crossref
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Cheng Jianghong, Sha Zizhuo, Zhang Ruisan, Ge Jinghao, Chen Peng, Kuang Xuefeng, Chang Jiazhi, Ren Kai, Luo Xianyang, Chen Shuai, Gou Xingchun, L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression, Bioengineered, 13, 3, 2022. Crossref