Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
Indexed in
Strategies for Tumor Elimination by Cytotoxic T Lymphocytes
RESUMO
Despite differences in their tissue of origin, many tumors share high level expression of certain tumor-associated proteins. Our laboratory has focused on the possibility of utilizing antigenic components of these proteins as a focus for T-cell immunotherapy of cancer. The advantage of targeting such commonly expressed proteins is the fact that such therapy could be of value in eliminating many different types of tumors. A potential barrier in the identification of T-cell epitopes derived from these proteins and presented by tumor cells is the fact that these proteins are also expressed at low levels in some normal tissues, and therefore, self-tolerance may eliminate T cells that are capable of recognizing these epitopes with high avidity. We have utilized two different murine model systems to explore the extent to which self-tolerance may limit the immune response to a tumor-specific antigen. The first compared the ability of mice deficient in expression of murine p53 (p53 knock-out mice) and normal mice, to respond against several epitopes of the p53 protein. The second model compares the ability of conventional mice with transgenic mice that express the influenza hemagglutinin in the periphery to respond to a dominant antigenic peptide of this transgene product. In both models we have investigated the effect self-tolerance has on elimination of tumors expressing the toleragen.
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Matzku Siegfried, Z??ller Margot, Specific Immunotherapy of Cancer in Elderly Patients, Drugs & Aging, 18, 9, 2001. Crossref
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Melief Cornelis J.M., Toes RenéE.M., Medema Jan Paul, Van Der Burg Sjoerd H., Ossendorp Ferry, Offringa Rienk, Strategies for immunotherapy of cancer, in Advances in Immunology Volume 75, 75, 2000. Crossref
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Ribas Antoni, Butterfield Lisa H., Hu Billy, Dissette Vivian B., Chen Angela Y., Koh Andrew, Amarnani Saral N., Glaspy John A., McBride William H., Economou James S., Generation of T-Cell Immunity to a Murine Melanoma Using MART-1–Engineered Dendritic Cells, Journal of Immunotherapy, 23, 1, 2000. Crossref
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Gordan J.D., Vonderheide R.H., Universal tumor antigens as targets for immunotherapy, Cytotherapy, 4, 4, 2002. Crossref
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Schultze J. L., Maecker B., Von Bergwelt-Baildon M. S., Anderson K. S., Vonderheide R. H., Tumour immunotherapy: new tools, new treatment modalities and new T-cell antigens, Vox Sanguinis, 80, 2, 2001. Crossref
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Li Liang-Ping, Lampert J Christoph, Chen Xiaojing, Leitao Catarina, Popović Jelena, Müller Werner, Blankenstein Thomas, Transgenic mice with a diverse human T cell antigen receptor repertoire, Nature Medicine, 16, 9, 2010. Crossref
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Theobald Matthias, Ruppert Thomas, Kuckelkorn Ulrike, Hernandez Javier, Häussler Annett, Ferreira Edite Antunes, Liewer Ulrike, Biggs Judith, Levine Arnold J., Huber Christoph, Koszinowski Ulrich H., Kloetzel Peter-M., Sherman Linda A., The Sequence Alteration Associated with a Mutational Hotspot in p53 Protects Cells From Lysis by Cytotoxic T Lymphocytes Specific for a Flanking Peptide Epitope , Journal of Experimental Medicine, 188, 6, 1998. Crossref
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LEIBOVITZ ARTHUR, BAUMOEHL YEHUDA, SEGAL RAFAEL, INCREASED INCIDENCE OF PATHOLOGICAL AND CLINICAL PROSTATE CANCER WITH AGE: AGE RELATED ALTERATIONS OF LOCAL IMMUNE SURVEILLANCE, Journal of Urology, 172, 2, 2004. Crossref
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Borberg Helmut, Quo vadis haemapheresis, Transfusion and Apheresis Science, 34, 1, 2006. Crossref
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Abele Rupert, Tampé Robert, Function of the transport complex TAP in cellular immune recognition, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1461, 2, 1999. Crossref
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Zöller Margot, Matzku Siegfried, Cancer Therapy: New Concepts on Active Immunization, Immunobiology, 201, 1, 1999. Crossref
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Ferriès Estelle, Connan Francine, Pagès Franck, Gaston Jésintha, Hagnéré Anne-Marie, Vieillefond Annick, Thiounn Nicolas, Guillet Jean-Gérard, Choppin Jeannine, Identification of p53 peptides recognized by CD8+ T lymphocytes from patients with bladder cancer, Human Immunology, 62, 8, 2001. Crossref
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Zöller Margot, Unexpected Induction of Unresponsiveness by Vaccination With Transformed Salmonella Typhimurium, Journal of Immunotherapy, 25, 2, 2002. Crossref
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Lankat-Buttgereit Brigitte, Tampé Robert, The Transporter Associated With Antigen Processing: Function and Implications in Human Diseases, Physiological Reviews, 82, 1, 2002. Crossref
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Kershaw Michael H., Westwood Jennifer A., Hwu Patrick, Dual-specific T cells combine proliferation and antitumor activity, Nature Biotechnology, 20, 12, 2002. Crossref
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Zöller Margot, Immunotherapy of Cancer by Active Vaccination: Does Allogeneic Bone Marrow Transplantation after Non-Myeloablative Conditioning Provide a New Option?, Technology in Cancer Research & Treatment, 2, 3, 2003. Crossref
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Hiltbold Elizabeth M., Vlad Anda M., Ciborowski Pawel, Watkins Simon C., Finn Olivera J., The Mechanism of Unresponsiveness to Circulating Tumor Antigen MUC1 Is a Block in Intracellular Sorting and Processing by Dendritic Cells, The Journal of Immunology, 165, 7, 2000. Crossref
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Berer A., Keil F., Haas O., Lechner K., Geissler K., Öhler L., Generation of Leukemia-Derived Dendritic Cells from Patients with AML, in Acute Leukemias VIII, 40, 2001. Crossref
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Hernández Javier, Lee Peter P., Davis Mark M., Sherman Linda A., The Use of HLA A2.1/p53 Peptide Tetramers to Visualize the Impact of Self Tolerance on the TCR Repertoire, The Journal of Immunology, 164, 2, 2000. Crossref
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Zhu Xiaoyun, Belmont Heather J., Price-Schiavi Shari, Liu Bai, Lee Hyung-il, Fernandez Marilyn, Wong Richard L., Builes Janette, Rhode Peter R., Wong Hing C., Visualization of p53264–272/HLA-A*0201 Complexes Naturally Presented on Tumor Cell Surface by a Multimeric Soluble Single-Chain T Cell Receptor, The Journal of Immunology, 176, 5, 2006. Crossref
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Theobald M., Towards Adoptive Immunotherapy Using High Affinity T Cell Receptors, in Transplantation in Hematology and Oncology II, 2003. Crossref
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Hernández Javier, Ko Alice, Sherman Linda A., CTLA-4 Blockade Enhances the CTL Responses to the p53 Self-Tumor Antigen, The Journal of Immunology, 166, 6, 2001. Crossref
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Rosenberg Steven A., Sherry Richard M., Morton Kathleen E., Scharfman William J., Yang James C., Topalian Suzanne L., Royal Richard E., Kammula Udai, Restifo Nicholas P., Hughes Marybeth S., Schwartzentruber Douglas, Berman David M., Schwarz Susan L., Ngo Lien T., Mavroukakis Sharon A., White Donald E., Steinberg Seth M., Tumor Progression Can Occur despite the Induction of Very High Levels of Self/Tumor Antigen-Specific CD8+ T Cells in Patients with Melanoma, The Journal of Immunology, 175, 9, 2005. Crossref
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Kazansky Dmitry B., Intrathymic Selection: New Insight into Tumor Immunology, in Immune-Mediated Diseases, 601, 2007. Crossref
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Calvo Roser, Drabkin Harry A., Embryonic genes in cancer, Annals of Oncology, 11, 2000. Crossref
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Lee Jaewoo, Fassnacht Martin, Nair Smita, Boczkowski David, Gilboa Eli, Tumor Immunotherapy Targeting Fibroblast Activation Protein, a Product Expressed in Tumor-Associated Fibroblasts, Cancer Research, 65, 23, 2005. Crossref
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Song Guang-Yun, Gibson Glen, Haq Wahajul, Huang Eric C. C., Srivasta Tumul, Hollstein Monica, Daftarian Pirouz, Wang Zhongde, Diamond Don, Ellenhorn Joshua D. I., An MVA vaccine overcomes tolerance to human p53 in mice and humans, Cancer Immunology, Immunotherapy, 56, 8, 2007. Crossref