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Critical Reviews™ in Immunology

Publicou 6 edições por ano

ISSN Imprimir: 1040-8401

ISSN On-line: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Strategies for Tumor Elimination by Cytotoxic T Lymphocytes

Volume 18, Edição 1-2, 1998, pp. 47-54
DOI: 10.1615/CritRevImmunol.v18.i1-2.60
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RESUMO

Despite differences in their tissue of origin, many tumors share high level expression of certain tumor-associated proteins. Our laboratory has focused on the possibility of utilizing antigenic components of these proteins as a focus for T-cell immunotherapy of cancer. The advantage of targeting such commonly expressed proteins is the fact that such therapy could be of value in eliminating many different types of tumors. A potential barrier in the identification of T-cell epitopes derived from these proteins and presented by tumor cells is the fact that these proteins are also expressed at low levels in some normal tissues, and therefore, self-tolerance may eliminate T cells that are capable of recognizing these epitopes with high avidity. We have utilized two different murine model systems to explore the extent to which self-tolerance may limit the immune response to a tumor-specific antigen. The first compared the ability of mice deficient in expression of murine p53 (p53 knock-out mice) and normal mice, to respond against several epitopes of the p53 protein. The second model compares the ability of conventional mice with transgenic mice that express the influenza hemagglutinin in the periphery to respond to a dominant antigenic peptide of this transgene product. In both models we have investigated the effect self-tolerance has on elimination of tumors expressing the toleragen.

CITADO POR
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  2. Wankowicz-Kalinska Anna, Mailliard Robbie B., Olson Kathleen, Graham Fiona, Edington Howard, Kirkwood John M., Martinek Stephanie, Das Pranab K., Storkus Walter J., Accumulation of low-avidity anti-melanocortin receptor 1 (anti-MC1R) CD8+ T cells in the lesional skin of a patient with melanoma-related depigmentation, Melanoma Research, 16, 2, 2006. Crossref

  3. Matzku Siegfried, Z??ller Margot, Specific Immunotherapy of Cancer in Elderly Patients, Drugs & Aging, 18, 9, 2001. Crossref

  4. Melief Cornelis J.M., Toes RenéE.M., Medema Jan Paul, Van Der Burg Sjoerd H., Ossendorp Ferry, Offringa Rienk, Strategies for immunotherapy of cancer, in Advances in Immunology Volume 75, 75, 2000. Crossref

  5. Ribas Antoni, Butterfield Lisa H., Hu Billy, Dissette Vivian B., Chen Angela Y., Koh Andrew, Amarnani Saral N., Glaspy John A., McBride William H., Economou James S., Generation of T-Cell Immunity to a Murine Melanoma Using MART-1–Engineered Dendritic Cells, Journal of Immunotherapy, 23, 1, 2000. Crossref

  6. Gordan J.D., Vonderheide R.H., Universal tumor antigens as targets for immunotherapy, Cytotherapy, 4, 4, 2002. Crossref

  7. Schultze J. L., Maecker B., Von Bergwelt-Baildon M. S., Anderson K. S., Vonderheide R. H., Tumour immunotherapy: new tools, new treatment modalities and new T-cell antigens, Vox Sanguinis, 80, 2, 2001. Crossref

  8. Li Liang-Ping, Lampert J Christoph, Chen Xiaojing, Leitao Catarina, Popović Jelena, Müller Werner, Blankenstein Thomas, Transgenic mice with a diverse human T cell antigen receptor repertoire, Nature Medicine, 16, 9, 2010. Crossref

  9. Theobald Matthias, Ruppert Thomas, Kuckelkorn Ulrike, Hernandez Javier, Häussler Annett, Ferreira Edite Antunes, Liewer Ulrike, Biggs Judith, Levine Arnold J., Huber Christoph, Koszinowski Ulrich H., Kloetzel Peter-M., Sherman Linda A., The Sequence Alteration Associated with a Mutational Hotspot in p53 Protects Cells From Lysis by Cytotoxic T Lymphocytes Specific for a Flanking Peptide Epitope , Journal of Experimental Medicine, 188, 6, 1998. Crossref

  10. LEIBOVITZ ARTHUR, BAUMOEHL YEHUDA, SEGAL RAFAEL, INCREASED INCIDENCE OF PATHOLOGICAL AND CLINICAL PROSTATE CANCER WITH AGE: AGE RELATED ALTERATIONS OF LOCAL IMMUNE SURVEILLANCE, Journal of Urology, 172, 2, 2004. Crossref

  11. Borberg Helmut, Quo vadis haemapheresis, Transfusion and Apheresis Science, 34, 1, 2006. Crossref

  12. Abele Rupert, Tampé Robert, Function of the transport complex TAP in cellular immune recognition, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1461, 2, 1999. Crossref

  13. Zöller Margot, Matzku Siegfried, Cancer Therapy: New Concepts on Active Immunization, Immunobiology, 201, 1, 1999. Crossref

  14. Ferriès Estelle, Connan Francine, Pagès Franck, Gaston Jésintha, Hagnéré Anne-Marie, Vieillefond Annick, Thiounn Nicolas, Guillet Jean-Gérard, Choppin Jeannine, Identification of p53 peptides recognized by CD8+ T lymphocytes from patients with bladder cancer, Human Immunology, 62, 8, 2001. Crossref

  15. Zöller Margot, Unexpected Induction of Unresponsiveness by Vaccination With Transformed Salmonella Typhimurium, Journal of Immunotherapy, 25, 2, 2002. Crossref

  16. Lankat-Buttgereit Brigitte, Tampé Robert, The Transporter Associated With Antigen Processing: Function and Implications in Human Diseases, Physiological Reviews, 82, 1, 2002. Crossref

  17. Kershaw Michael H., Westwood Jennifer A., Hwu Patrick, Dual-specific T cells combine proliferation and antitumor activity, Nature Biotechnology, 20, 12, 2002. Crossref

  18. Zöller Margot, Immunotherapy of Cancer by Active Vaccination: Does Allogeneic Bone Marrow Transplantation after Non-Myeloablative Conditioning Provide a New Option?, Technology in Cancer Research & Treatment, 2, 3, 2003. Crossref

  19. Hiltbold Elizabeth M., Vlad Anda M., Ciborowski Pawel, Watkins Simon C., Finn Olivera J., The Mechanism of Unresponsiveness to Circulating Tumor Antigen MUC1 Is a Block in Intracellular Sorting and Processing by Dendritic Cells, The Journal of Immunology, 165, 7, 2000. Crossref

  20. Berer A., Keil F., Haas O., Lechner K., Geissler K., Öhler L., Generation of Leukemia-Derived Dendritic Cells from Patients with AML, in Acute Leukemias VIII, 40, 2001. Crossref

  21. Hernández Javier, Lee Peter P., Davis Mark M., Sherman Linda A., The Use of HLA A2.1/p53 Peptide Tetramers to Visualize the Impact of Self Tolerance on the TCR Repertoire, The Journal of Immunology, 164, 2, 2000. Crossref

  22. Zhu Xiaoyun, Belmont Heather J., Price-Schiavi Shari, Liu Bai, Lee Hyung-il, Fernandez Marilyn, Wong Richard L., Builes Janette, Rhode Peter R., Wong Hing C., Visualization of p53264–272/HLA-A*0201 Complexes Naturally Presented on Tumor Cell Surface by a Multimeric Soluble Single-Chain T Cell Receptor, The Journal of Immunology, 176, 5, 2006. Crossref

  23. Theobald M., Towards Adoptive Immunotherapy Using High Affinity T Cell Receptors, in Transplantation in Hematology and Oncology II, 2003. Crossref

  24. Hernández Javier, Ko Alice, Sherman Linda A., CTLA-4 Blockade Enhances the CTL Responses to the p53 Self-Tumor Antigen, The Journal of Immunology, 166, 6, 2001. Crossref

  25. Rosenberg Steven A., Sherry Richard M., Morton Kathleen E., Scharfman William J., Yang James C., Topalian Suzanne L., Royal Richard E., Kammula Udai, Restifo Nicholas P., Hughes Marybeth S., Schwartzentruber Douglas, Berman David M., Schwarz Susan L., Ngo Lien T., Mavroukakis Sharon A., White Donald E., Steinberg Seth M., Tumor Progression Can Occur despite the Induction of Very High Levels of Self/Tumor Antigen-Specific CD8+ T Cells in Patients with Melanoma, The Journal of Immunology, 175, 9, 2005. Crossref

  26. Kazansky Dmitry B., Intrathymic Selection: New Insight into Tumor Immunology, in Immune-Mediated Diseases, 601, 2007. Crossref

  27. Calvo Roser, Drabkin Harry A., Embryonic genes in cancer, Annals of Oncology, 11, 2000. Crossref

  28. Lee Jaewoo, Fassnacht Martin, Nair Smita, Boczkowski David, Gilboa Eli, Tumor Immunotherapy Targeting Fibroblast Activation Protein, a Product Expressed in Tumor-Associated Fibroblasts, Cancer Research, 65, 23, 2005. Crossref

  29. Song Guang-Yun, Gibson Glen, Haq Wahajul, Huang Eric C. C., Srivasta Tumul, Hollstein Monica, Daftarian Pirouz, Wang Zhongde, Diamond Don, Ellenhorn Joshua D. I., An MVA vaccine overcomes tolerance to human p53 in mice and humans, Cancer Immunology, Immunotherapy, 56, 8, 2007. Crossref

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