Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
Indexed in
Signal Integration Following Toll-like Receptor Triggering
RESUMO
Innate immune cells sense infectious danger through recognition of pathogen-associated molecular patterns (PAMP). Toll-like receptors (TLRs) play a pivotal role in the recognition of PAMP. Although various TLRs with distinct ligand specificities are expressed almost completely and contemporaneously by innate immune cells, and although central key signal transduction pathways of TLRs are shared, the innate response pattern is not uniform. Innate immune cells organize their response dependent on spatial and temporal requirements and mount a pathogen-specific and microbial-adopted reaction. Thus, after triggering of TLRs, complex signaling interactions take place that control and shape the reactivity patterns of innate immune cells. Here we discuss the central signaling pathways of TLRs and their interconnection with other signaling pathways, with emphasis on Janus kinases/signal transducers and activators of transcription (JAK/STAT)-dependent intracellular signals. Cis and trans acting signal convergence mechanisms and mutual influence of TLR and cytokine signaling pathways determine the response profile. Hence, in innate immune cells, integration and processing of microbial-dependent and immunologic signals is achieved within individual cells to ascertain an appropriate immune response. Knowledge of these complex mechanisms will help to clarify the critical events during initiation of infection, which in turn may lead to new strategies to control and overcome infectious disease.
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Roux Christelle M., Rolán Hortensia G., Santos Renato L., Beremand Phillip D., Thomas Terry L., Adams L. Garry, Tsolis Renée M., Brucella requires a functional Type IV secretion system to elicit innate immune responses in mice, Cellular Microbiology, 9, 7, 2007. Crossref
-
Werling Dirk, Hope Jayne C., Howard Chris J., Jungi Thomas W., Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists, Immunology, 111, 1, 2004. Crossref
-
Chow Donna A., Physiological Activities of the Natural Immune System, in Natural Immunity, 5, 2005. Crossref
-
Wujcicka Wioletta, Wilczyński Jan, Nowakowska Dorota, Alterations inTLRsas new molecular markers of congenital infections withHuman cytomegalovirus?, Pathogens and Disease, 70, 1, 2014. Crossref
-
Hung C.-C., Chang C.-T., Chen K.-H., Tian Y.-C., Wu M.-S., Pan M.-J., Vandewalle A., Yang C.-W., Upregulation of chemokine CXCL1/KC by leptospiral membrane lipoprotein preparation in renal tubule epithelial cells, Kidney International, 69, 10, 2006. Crossref
-
MOORMANN A. M., How might infant and paediatric immune responses influence malaria vaccine efficacy?, Parasite Immunology, 31, 9, 2009. Crossref
-
Li Zheng-Hong, Chu Niansheng, Shan Li-Dong, Gong Shan, Yin Qi-Zhang, Jiang Xing-Hong, Inducible Expression of Functional Mu Opioid Receptors in Murine Dendritic Cells, Journal of Neuroimmune Pharmacology, 4, 3, 2009. Crossref
-
Wagner Erwin F., Eferl Robert, Fos/AP-1 proteins in bone and the immune system, Immunological Reviews, 208, 1, 2005. Crossref
-
Abreu Maria T., Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function, Nature Reviews Immunology, 10, 2, 2010. Crossref
-
Becker K.J., Sensitization and tolerization to brain antigens in stroke, Neuroscience, 158, 3, 2009. Crossref
-
Blatteis Clark M., Endotoxic fever: New concepts of its regulation suggest new approaches to its management, Pharmacology & Therapeutics, 111, 1, 2006. Crossref
-
Heeg Klaus, Dalpke Alexander, TLR-induced negative regulatory circuits: role of suppressor of cytokine signaling (SOCS) proteins in innate immunity, Vaccine, 21, 2003. Crossref
-
Dalpke Alexander H., Heeg Klaus, CpG-DNA as immune response modifier, International Journal of Medical Microbiology, 294, 5, 2004. Crossref
-
Lu Zhongyang, Zhang Xiaoming, Li Yanchun, Lopes-Virella Maria F., Huang Yan, TLR4 antagonist attenuates atherogenesis in LDL receptor-deficient mice with diet-induced type 2 diabetes, Immunobiology, 220, 11, 2015. Crossref
-
Blatteis Clark M., Li Shuxin, Li Zhonghua, Feleder Carlos, Perlik Vit, Cytokines, PGE2 and endotoxic fever: a re-assessment, Prostaglandins & Other Lipid Mediators, 76, 1-4, 2005. Crossref
-
Dalpke Alexander, Heeg Klaus, Bartz Holger, Baetz Andrea, Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins, Immunobiology, 213, 3-4, 2008. Crossref
-
Li Changlin, Yu Yongshen, Wang Yun, Liu Lei, Zhang Min, Sugano Sumio, Wang Zhengguo, Chang Zongliang, Both ERK and JNK are required for enhancement of MD-2 gene expression during differentiation of HL-60 cells, Biology of the Cell, 100, 6, 2008. Crossref
-
Pan Li-Long, Zhang Qiu-Yang, Luo Xiao-Ling, Xiong Juan, Xu Peng, Liu Si-Yu, Hu Jin-Feng, Liu Xin-Hua, (7R,8S)-9-Acetyl-dehydrodiconiferyl alcohol inhibits inflammation and migration in lipopolysaccharide-stimulated macrophages, Phytomedicine, 23, 5, 2016. Crossref
-
Herkenham Miles, Involvement of the Choroid Plexus and the Cerebrospinal Fluid in Immune Molecule Signaling in the Central Nervous System, in The Blood-Cerebrospinal Fluid Barrier, 2005. Crossref
-
Tayabali Azam F., Nguyen Kathy C., Shwed Philip S., Crosthwait Jennifer, Coleman Gordon, Seligy Verner L., Adler Ben, Comparison of the Virulence Potential of Acinetobacter Strains from Clinical and Environmental Sources, PLoS ONE, 7, 5, 2012. Crossref
-
Kojima Keishi, Musch Mark W., Ropeleski Mark J., Boone David L., Ma Averil, Chang Eugene B., Escherichia coli LPS induces heat shock protein 25 in intestinal epithelial cells through MAP kinase activation, American Journal of Physiology-Gastrointestinal and Liver Physiology, 286, 4, 2004. Crossref
-
Ochoa-Cortes Fernando, Ramos-Lomas Telma, Miranda-Morales Marcela, Spreadbury Ian, Ibeakanma Charles, Barajas-Lopez Carlos, Vanner Stephen, Bacterial cell products signal to mouse colonic nociceptive dorsal root ganglia neurons, American Journal of Physiology-Gastrointestinal and Liver Physiology, 299, 3, 2010. Crossref
-
Li Zhonghua, Perlik Vit, Feleder Carlos, Tang Ying, Blatteis Clark M., Kupffer cell-generated PGE2triggers the febrile response of guinea pigs to intravenously injected LPS, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 290, 5, 2006. Crossref
-
Severgnini Mariano, Takahashi Satoe, Rozo Liliana M., Homer Robert J., Kuhn Charles, Jhung Jhung W., Perides George, Steer Michael, Hassoun Paul M., Fanburg Barry L., Cochran Brent H., Simon Amy R., Activation of the STAT pathway in acute lung injury, American Journal of Physiology-Lung Cellular and Molecular Physiology, 286, 6, 2004. Crossref
-
Donninelli Gloria, Sanseverino Isabella, Purificato Cristina, Gessani Sandra, Gauzzi Maria Cristina, Dual requirement for STAT signaling in dendritic cell immunobiology, Immunobiology, 223, 3, 2018. Crossref
-
Frost Robert A., Nystrom Gerald J., Lang Charles H., Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C2C12myoblasts via Toll-like receptor-4 and c-Jun NH2-terminal kinase pathways, American Journal of Physiology-Cell Physiology, 287, 6, 2004. Crossref
-
Shen Chen, Chen Jin Hong, Lee Youngyi, Hassan Md. Mehedi, Kim Su Jin, Choi Eun Young, Hong Seong-Tshool, Park Byung-Hyun, Park Ji Hyun, mTOR- and SGK-Mediated Connexin 43 Expression Participates in Lipopolysaccharide-Stimulated Macrophage Migration through the iNOS/Src/FAK Axis, The Journal of Immunology, 201, 10, 2018. Crossref
-
Miller Richard J., Jung Hosung, Bhangoo Sonia K., White Fletcher A., Cytokine and Chemokine Regulation of Sensory Neuron Function, in Sensory Nerves, 194, 2009. Crossref
-
Decker Thomas, Müller Mathias, Kovarik Pavel, Regulation of STATs by Posttranslational Modifications, in Signal Transducers and Activators of Transcription (STATs), 2003. Crossref
-
Boivin Nicolas, Sergerie Yan, Rivest Serge, Boivin Guy, Effect of Pretreatment with Toll‐like Receptor Agonists in a Mouse Model of Herpes Simplex Virus Type 1 Encephalitis, The Journal of Infectious Diseases, 198, 5, 2008. Crossref
-
Wan Xianxiu, Garg Nisha Jain, Sirtuin Control of Mitochondrial Dysfunction, Oxidative Stress, and Inflammation in Chagas Disease Models, Frontiers in Cellular and Infection Microbiology, 11, 2021. Crossref