Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
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T Cell Activation Pathways: B7, LFA-3, and ICAM-1 Shape Unique T Cell Profiles
RESUMO
Two signals are required for induction of cell proliferation and cytokine production in resting T cells. Occupancy of the T cell receptor by antigen/MHC complexes delivers the first signal to the T cell, while the second signal is provided by interaction with costimulatory ligands on APC. CD2, LFA-1, and CD28 are the major costimulatory and adhesive molecules on T cells and bind to the LFA-3, ICAM-1 and B7 ligands, respectively, on APC. LFA-3 plays a central role for naive and memory T helper cells during the early phase of an immune response. The LFA-3/CD2 pathway initiates strong antigen-independent cell adhesion, substantial expansion of naive T helper cells, and induction of large amounts of IFN-γ in memory cells.
The release of IFN-γ may upregulate expression of ICAM-1 and B7 on APC and allows multiple adhesion pathways to amplify the immune response. The LFA- 1/ICAM-l pathway stimulates adhesion and cell proliferation more efficiently in memory T helper cells than in naive cells. Further, the results suggest that naive T helper cells express functionally inactive LFA-1 molecules on the cell surface, which may have a physiological role in keeping these cells in a resting state. B7 costimulation superinduces IL-2 production in both naive and memory T helper cells and generates long-lasting cell proliferation. This permits transition from an autocrine to a paracrine immune response. Coexpression of B7/LFA-3 provides an optimal APC function and enables a vigorous T cell response to minute amounts of antigen. AP-1 and NF-κB transcription factors are involved in the induction of several cytokine gene promoters and play a central role in the regulation of IL-2 gene transcription. LFA-3 costimulation only moderately enhances AP-1 DNA-binding activity and does not influence the NF-κB activity induced by TCR engagement, whereas B7 costimulation induces large amounts of NF-κB and AP-1 activity in T helper cells. The costimulatory ligands represent a family of adhesion molecules with considerable redundancy. Interfamily redundancy of LFA-3, B7, and ICAM ligands offers an opportunity to regulate distinct T cell response profiles in various microenvironments at separate time points of an immune response.
-
Hilliard Brendan A., Mason Nicola, Xu Lingyun, Sun Jing, Lamhamedi-Cherradi Salah-Eddine, Liou Hsiou-Chi, Hunter Christopher, Chen Youhai H., Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation, Journal of Clinical Investigation, 110, 6, 2002. Crossref
-
Wanschitz Felix, Nell Andrea, Patruta Sanda, Wagner Arne, Ewers Rolf, Influence of three currently used bone replacing materials on thein vitroproliferation of human peripheral blood mononuclear cells, Clinical Oral Implants Research, 16, 5, 2005. Crossref
-
Hewson Tim, Lone Nazir, Moore Marilyn, Howie Sarah, Interactions of HIV-1 with antigen-presenting cells, Immunology and Cell Biology, 77, 4, 1999. Crossref
-
Prinz JC, The role of T cells in psoriasis, Journal of the European Academy of Dermatology and Venereology, 17, 3, 2003. Crossref
-
Dunnion D. J., Cywinski A. L., Tucker V. C., Murray A. K., Rickinson A. B., Coulie P., Browning M. J., Human antigen-presenting cell/tumour cell hybrids stimulate strong allogeneic responses and present tumour-associated antigens to cytotoxic T cells in vitro , Immunology, 98, 4, 1999. Crossref
-
Hall Simon R., Rhodes John, Schiff base-mediated co-stimulation primes the T-cell-receptor-dependent calcium signalling pathway in CD4 T cells, Immunology, 104, 1, 2001. Crossref
-
ABRAMS SCOTT I., Development of Epitope-Specific Immunotherapies for Human Malignancies and Premalignant Lesions Expressing Mutated ras Genes, in Gene Therapy of Cancer, 2002. Crossref
-
Schlom Jeffrey, Hodse James W., The diversity of T-cell co-stimulation in the induction of antitumor immunity, Immunological Reviews, 170, 1, 1999. Crossref
-
Salucci V., Lena A. M., Ciliberto G., Scarselli E., La Monica N., Adenovirus Transduction and Culture Conditions Affect the Immunogenicity of Murine Dendritic Cells, Scandinavian Journal of Immunology, 62, 3, 2005. Crossref
-
Nicola Nicos A., Hilton Douglas J., General Classes and Functions of Four-Helix Bundle Cytokines, in Cytokines, 52, 1998. Crossref
-
Taylor Alison, Verhagen Johan, Blaser Kurt, Akdis Mubeccel, Akdis Cezmi A., Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells, Immunology, 117, 4, 2006. Crossref
-
Riley Roger S., Mageau Ronald, Ben-Ezra Jonathan, Laboratory Evaluation of the Cellular Immune System, in Henry's Clinical Diagnosis and Management by Laboratory Methods, 2011. Crossref
-
Hilliard Brendan A., Mason Nicola, Xu Lingyun, Sun Jing, Lamhamedi-Cherradi Salah-Eddine, Liou Hsiou-Chi, Hunter Christopher, Chen Youhai H., Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation, Journal of Clinical Investigation, 110, 6, 2002. Crossref
-
Kenneth B. Gordon, Thomas S. McCormick, Evolution of Biologic Therapies for the Treatment of Psoriasis, SKINmed: Dermatology for the Clinician, 2, 5, 2003. Crossref
-
Lagaudrière-Gesbert Cécile, Lebel-Binay Sophie, Hubeau Cedric, Fradelizi Didier, Conjeaud Hélène, Signaling through the tetraspanin CD82 triggers its association with the cytoskeleton leading to sustained morphological changes and T cell activation, European Journal of Immunology, 28, 12, 1998. Crossref
-
Remondo Cinzia, Gulley James L, Immunotherapy for prostate cancer, in Targeted Therapies for Castration-Resistant Prostate Cancer, 2011. Crossref
-
Altin Joseph G, Sloan Erica K, The role of CD45 and CD45-associated molecules in T cell activation, Immunology and Cell Biology, 75, 5, 1997. Crossref
-
La Flamme Anne C., Kahn Stuart J., Rudensky Alexander Y., Van Voorhis Wesley C., Trypanosoma cruzi-infected macrophages are defective in major histocompatibility complex class II antigen presentation, European Journal of Immunology, 27, 12, 1997. Crossref
-
Hilliard Brendan A., Mason Nicola, Xu Lingyun, Sun Jing, Lamhamedi-Cherradi Salah-Eddine, Liou Hsiou-Chi, Hunter Christopher, Chen Youhai H., Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation, Journal of Clinical Investigation, 110, 6, 2002. Crossref
-
McMichael Amy J., Excimer Laser: A Module of the Alopecia Areata Common Protocol, Journal of Investigative Dermatology Symposium Proceedings, 16, 1, 2013. Crossref
-
Ward Robert C., Kaufman Howard L., Targeting Costimulatory Pathways for Tumor Immunotherapy, International Reviews of Immunology, 26, 3-4, 2007. Crossref
-
Clinical Protocol: A Phase I Trial of Intra Lesional RV-B7.1 Vaccine in the Treatment of Malignant Melanoma. Albert Einstein Center, Bronx, New York., Human Gene Therapy, 11, 7, 2000. Crossref
-
EVANS GERALD A., FARRAR WILLIAM L., Purification of the Renaturable Protein Kinase PK55 by Preparative Isoelectric Focusing and High Performance Electrophoretic Chromatography and the Generation of PK55 Monoclonal Antibodies by In Vitro B Cell Stimulation, Hybridoma, 16, 6, 1997. Crossref
-
Avitahl Nicole, Winandy Susan, Friedrich Christof, Jones Beverly, Ge Yimin, Georgopoulos Katia, Ikaros Sets Thresholds for T Cell Activation and Regulates Chromosome Propagation, Immunity, 10, 3, 1999. Crossref
-
Palena Claudia, Abrams Scott I., Schlom Jeffrey, Hodge James W., , 95, 2006. Crossref
-
Schlom Jeffrey, Tsang Kwong-Yok, Kantor Judith A, Abrams Scott I, Zaremba Sam, Greiner John, Hodge James W, Cancer vaccine development, Expert Opinion on Investigational Drugs, 7, 9, 1998. Crossref
-
Gandolfi A., Cell receptor occupancy during cell-to-cell adhesion, Mathematical and Computer Modelling, 31, 4-5, 2000. Crossref
-
Grosenbach Douglas W., Schlom Jeffrey, Gritz Linda, Gómez Yafal Alicia, Hodge James W., A recombinant vector expressing transgenes for four T-cell costimulatory molecules (OX40L, B7-1, ICAM-1, LFA-3) induces sustained CD4+ and CD8+ T-cell activation, protection from apoptosis, and enhanced cytokine production, Cellular Immunology, 222, 1, 2003. Crossref
-
Eriksson Håkan, Proteolytic cleavage of MHC class I by complement C1-esterases—an overlooked mechanism?, Immunotechnology, 2, 3, 1996. Crossref
-
Briones J., Timmerman J. M., Panicalli D. L., Levy R., Antitumor Immunity After Vaccination With B Lymphoma Cells Overexpressing a Triad of Costimulatory Molecules, JNCI Journal of the National Cancer Institute, 95, 7, 2003. Crossref
-
Shankar Pragyna, Schlom Jeffrey, Hodge James W., Enhanced activation of rhesus T cells by vectors encoding a triad of costimulatory molecules (B7-1, ICAM-1, LFA-3), Vaccine, 20, 5-6, 2001. Crossref
-
Britten Cedrik M, Meyer Ralf G, Kreer Tanja, Drexler Ingo, Wölfel Thomas, Herr Wolfgang, The use of HLA-A*0201-transfected K562 as standard antigen-presenting cells for CD8+ T lymphocytes in IFN-γ ELISPOT assays, Journal of Immunological Methods, 259, 1-2, 2002. Crossref
-
Costa Maria Fernanda S., Nihei Jorge, Mengel José, Henriques Maria Graças, Penido Carmen, Requirement of L-selectin for γδ T lymphocyte activation and migration during allergic pleurisy: Co-relation with eosinophil accumulation, International Immunopharmacology, 9, 3, 2009. Crossref
-
Bazzi Samer, Modjtahedi Helmout, Mudan Satvinder, Akle Charles, Bahr Georges M., Analysis of the immunomodulatory properties of two heat-killed mycobacterial preparations in a human whole blood model, Immunobiology, 220, 12, 2015. Crossref
-
Hodge James W, Tsang Kwong-Yok, Poole Diane J, Schlom Jeffrey, General Keynote: Vaccine Strategies for the Therapy of Ovarian Cancer, Gynecologic Oncology, 88, 1, 2003. Crossref
-
Framson Paul E., Cho Diane H., Lee Lawrence Y., Hershberg Robert M., Polarized expression and function of the costimulatory molecule CD58 on human intestinal epithelial cells, Gastroenterology, 116, 5, 1999. Crossref
-
Müller-Alouf Heide, Gerlach Dieter, Desreumaux Pierre, Leportier Christelle, Alouf Joseph E., Capron Monique, Streptococcal pyrogenic exotoxin A (SPE A) superantigen induced production of hematopoietic cytokines, IL-12 and IL-13 by human peripheral blood mononuclear cells, Microbial Pathogenesis, 23, 5, 1997. Crossref
-
Zhou Hao, Zou Ping, Chen Zhi-chao, You Yong, A novel vicious cycle cascade in tumor chemotherapy, Medical Hypotheses, 69, 6, 2007. Crossref
-
Mehlis Stephanie L, Gordon Kenneth B, The immunology of psoriasis and biologic immunotherapy, Journal of the American Academy of Dermatology, 49, 2, 2003. Crossref
-
Linton Phyllis-Jean, Lustgarten Joseph, Thoman Marilyn, T cell function in the aged: Lessons learned from animal models, Clinical and Applied Immunology Reviews, 6, 2, 2006. Crossref
-
Tzu Julia, Mamelak Adam J., Sauder Daniel N., Current advancements in the treatment of psoriasis: Immunobiologic agents, Clinical and Applied Immunology Reviews, 6, 2, 2006. Crossref
-
Ginn-Pease Margaret E, Whisler Ronald L, Redox Signals and NF-κB Activation in T Cells, Free Radical Biology and Medicine, 25, 3, 1998. Crossref
-
Teschner D., Wenzel G., Distler E., Schnürer E., Theobald M., Neurauter A. A., Schjetne K., Herr W., In Vitro Stimulation and Expansion of Human Tumour-Reactive CD8+ Cytotoxic T Lymphocytes by Anti-CD3/CD28/CD137 Magnetic Beads, Scandinavian Journal of Immunology, 74, 2, 2011. Crossref
-
Tannenbaum Charles S., Hamilton Thomas A., Immune-inflammatory mechanisms in IFNγ-mediated anti-tumor activity, Seminars in Cancer Biology, 10, 2, 2000. Crossref
-
Taylor Alison, Verhagen Johan, Akkoç Tunç, Wenig Renate, Flory Egbert, Blaser Kurt, Akdis Mübeccel, Akdis Cezmi A., IL-10 suppresses CD2-mediated T cell activation via SHP-1, Molecular Immunology, 46, 4, 2009. Crossref
-
Hui George, Hashimoto Caryn, The requirement of CD80, CD86, and ICAM-1 on the ability of adjuvant formulations to potentiate antibody responses to a Plasmodium falciparum blood-stage vaccine, Vaccine, 25, 51, 2007. Crossref
-
Hodge James W, Grosenbach Douglas W, Schlom Jeffrey, Vector-based delivery of tumor-associated antigens and T-cell co-stimulatory molecules in the induction of immune responses and anti-tumor immunity, Cancer Detection and Prevention, 26, 4, 2002. Crossref
-
Sporici Romeo A., Perrin Peter J., Costimulation of Memory T-Cells by ICOS: A Potential Therapeutic Target for Autoimmunity?, Clinical Immunology, 100, 3, 2001. Crossref
-
Rad Ariel N, Schlom Jeffrey, Hodge James W, Vector-driven hyperexpression of a triad of costimulatory molecules confers enhanced T-cell stimulatory capacity to DC precursors, Critical Reviews in Oncology/Hematology, 39, 1-2, 2001. Crossref
-
Hodge James W, Grosenbach Douglas W, Rad Ariel N, Giuliano Mariateresa, Sabzevari Helen, Schlom Jeffrey, Enhancing the potency of peptide-pulsed antigen presenting cells by vector-driven hyperexpression of a triad of costimulatory molecules, Vaccine, 19, 25-26, 2001. Crossref
-
Kim Hye-Ran, Jeon Byeong-Hun, Lee Hyun-Su, Im Sin-Hyeog, Araki Masatake, Araki Kimi, Yamamura Ken-ichi, Choi Suck-Chei, Park Do-Sim, Jun Chang-Duk, IGSF4 is a novel TCR ζ-chain–interacting protein that enhances TCR-mediated signaling, Journal of Experimental Medicine, 208, 12, 2011. Crossref
-
Marlin Steven D., Rothlein Robert, Intercellular Adhesion Molecules: ICAM-1, ICAM-2 And ICAM-3, in Encyclopedia of Immunology, 1998. Crossref
-
Rakasz Eva, Sandor Matyas, Hagen Michael, Lynch Richard G., Activation features of intraepithelial γδ T-cells of the murine vagina, Immunology Letters, 54, 2-3, 1996. Crossref
-
Vanderlugt Carol L, Rahbe Sandra M, Elliott Peter J, Dal Canto Mauro C, Miller Stephen D, Treatment of Established Relapsing Experimental Autoimmune Encephalomyelitis with the Proteasome Inhibitor PS-5191, Journal of Autoimmunity, 14, 3, 2000. Crossref
-
Hodge J. W., Rad A. N., Grosenbach D. W., Sabzevari H., Yafal A. G., Gritz L., Schlom J., Enhanced Activation of T Cells by Dendritic Cells Engineered to Hyperexpress a Triad of Costimulatory Molecules, JNCI Journal of the National Cancer Institute, 92, 15, 2000. Crossref
-
Kohm Adam P., Miller Stephen D., Role of ICAM-1 and P-selectin expression in the development and effector function of CD4+CD25+regulatory T cells, Journal of Autoimmunity, 21, 3, 2003. Crossref
-
Findlay Lucy, Sharp Giles, Fox Bernard, Ball Christina, Robinson C. Jane, Bird Christopher, Stebbings Richard, Eastwood David, Wadhwa Meenu, Poole Stephen, Thorpe Robin, Thorpe Susan J., Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture, Cytokine, 55, 1, 2011. Crossref
-
Madan Ravi A, Arlen Philip M, Gulley James L, PANVAC™-VF: poxviral-based vaccine therapy targeting CEA and MUC1 in carcinoma, Expert Opinion on Biological Therapy, 7, 4, 2007. Crossref
-
Kalamasz Dale, Long S. A., Taniguchi Ruth, Buckner Jane H., Berenson Ronald J., Bonyhadi Mark, Optimization of Human T-Cell Expansion Ex Vivo Using Magnetic Beads Conjugated with Anti-CD3 and Anti-CD28 Antibodies, Journal of Immunotherapy, 27, 5, 2004. Crossref
-
Dalirfardouei Razieh, Karimi Gholamreza, Jamialahmadi Khadijeh, Molecular mechanisms and biomedical applications of glucosamine as a potential multifunctional therapeutic agent, Life Sciences, 152, 2016. Crossref
-
Schlom J., Sabzevari H., Grosenbach D. W., Hodge J. W., A Triad of Costimulatory Molecules Synergize to Amplify T‐‐Cell Activation in Both Vector‐‐Based and Vector‐‐Infected Dendritic Cell Vaccines, Artificial Cells, Blood Substitutes, and Biotechnology, 31, 2, 2003. Crossref
-
Madan Ravi A, Arlen Philip M, Mohebtash Mahsa, Hodge James W, Gulley James L, Prostvac-VF: a vector-based vaccine targeting PSA in prostate cancer, Expert Opinion on Investigational Drugs, 18, 7, 2009. Crossref
-
Rocha-Perugini Vera, Sánchez-Madrid Francisco, Martínez del Hoyo Gloria, Function and Dynamics of Tetraspanins during Antigen Recognition and Immunological Synapse Formation, Frontiers in Immunology, 6, 2016. Crossref
-
Dangles Virginie, Validire Pierre, Wertheimer Mireille, Richon Sophie, Bovin Christophe, Zeliszewski Dominique, Vallancien Guy, Bellet Dominique, Impact of human bladder cancer cell architecture on autologous T-lymphocyte activation, International Journal of Cancer, 98, 1, 2002. Crossref
-
A Phase I Trial of Intralesional rV-Tricom Vaccine in the Treatment of Malignant Melanoma, Human Gene Therapy, 12, 11, 2001. Crossref
-
Cole Grace, Dunne Nicholas J., McCarthy Helen O., Microneedles for Gene Therapy: Overcoming Extracellular and Intracellular Barriers, in Microneedles for Drug and Vaccine Delivery and Patient Monitoring, 2018. Crossref
-
Agrawal Babita, Gupta Nancy, Konowalchuk Jeffrey D., MUC1 Mucin: A Putative Regulatory (Checkpoint) Molecule of T Cells, Frontiers in Immunology, 9, 2018. Crossref
-
Lausen Mads, Poulsen Thomas B.G., Christiansen Gunna, Kastaniegaard Kenneth, Stensballe Allan, Birkelund Svend, Proteomic analysis of lipopolysaccharide activated human monocytes, Molecular Immunology, 103, 2018. Crossref
-
Uzendoski Kerry, Kantor Judy A., Abrams Scott I., Schlom Jeffrey, Hodge James W., Construction and Characterization of a Recombinant Vaccinia Virus Expressing Murine Intercellular Adhesion Molecule-1: Induction and Potentiation of Antitumor Responses, Human Gene Therapy, 8, 7, 1997. Crossref
-
Intra-Lesional rF-B7.1 Versus rF-TRICOM Vaccine in the Treatment of Metastatic Cancer, Human Gene Therapy, 14, 8, 2003. Crossref
-
Pinto Bruna, Medeiros Nayara, Fontes-Cal Tereza, Naziazeno Isabela, Correa-Oliveira Rodrigo, Dutra Walderez, Gomes Juliana, The Role of Co-Stimulatory Molecules in Chagas Disease, Cells, 7, 11, 2018. Crossref
-
El Menshawy Nadia, Eissa Mohammed, Abdeen Hanaa M., Elkhamisy Enas M., Joseph Nabil, CD58; leucocyte function adhesion-3 (LFA-3) could be used as a differentiating marker between immune and non-immune thyroid disorders, Comparative Clinical Pathology, 27, 3, 2018. Crossref
-
Agrawal Babita, New therapeutic targets for cancer: the interplay between immune and metabolic checkpoints and gut microbiota, Clinical and Translational Medicine, 8, 1, 2019. Crossref
-
Wolk Kerstin, Döcke Wolf-Dietrich, von Baehr Volker, Volk Hans-Dieter, Sabat Robert, Impaired antigen presentation by human monocytes during endotoxin tolerance, Blood, 96, 1, 2000. Crossref
-
Hodge J. W., Schlom J., Costimulatory Molecules in Vaccine Design, in Therapeutic Vaccination Strategies, 2000. Crossref
-
Madan Ravi A., Gulley James L., Celestin Jackie, Arlen Philip M., Schlom Jeffrey, Cancer Immunology, Immunotherapeutics, and Vaccine Approaches, in Drug Management of Prostate Cancer, 2010. Crossref
-
Murad Kari L., Gosselin Edmund J., Eaton John W., Scott Mark D., Stealth Cells: Prevention of Major Histocompatibility Complex Class II-Mediated T-Cell Activation by Cell Surface Modification, Blood, 94, 6, 1999. Crossref
-
Naisbitt Dean J., Gordon Sfraser, Pirmohamed Munir, Park Bkevin, Immunological Principles of Adverse Drug Reactions, Drug Safety, 23, 6, 2000. Crossref
-
Gulley James L., Arlen Philip M., Schlom Jeffrey, Pox Viral Vaccines, in Handbook of Cancer Vaccines, 2004. Crossref
-
Newrzela Sebastian, Gunda Brandenburg, Laer Dorothee von, T Cell Culture for Gammaretroviral Transfer, in Genetic Modification of Hematopoietic Stem Cells, 506, 2009. Crossref
-
Stavridis John C., Oxidative Activation of Transcription Factor Pathways by Cigarette Smoke Oxidants, in Oxidation: The Cornerstone of Carcinogenesis, 2008. Crossref
-
Orlik Christian, Deibel Daniel, Küblbeck Johanna, Balta Emre, Ganskih Sabina, Habicht Jüri, Niesler Beate, Schröder-Braunstein Jutta, Schäkel Knut, Wabnitz Guido, Samstag Yvonne, Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin, Cellular & Molecular Immunology, 17, 4, 2020. Crossref
-
Chen Audrey M., Scott Mark D., Current and Future Applications of Immunological Attenuation via Pegylation of Cells and Tissue, BioDrugs, 15, 12, 2001. Crossref
-
Villegas Eric N., Lieberman Linda A., Mason Nicola, Blass Sarah L., Zediak Valerie P., Peach Robert, Horan Tom, Yoshinaga Steve, Hunter Christopher A., A Role for Inducible Costimulator Protein in the CD28- Independent Mechanism of Resistance toToxoplasma gondii, The Journal of Immunology, 169, 2, 2002. Crossref
-
Burkly Linda C., CD40L Pathway Blockade as an Approach to Immunotherapy, in Hemophilia Care in the New Millennium, 489, 2001. Crossref
-
Wolk Kerstin, Döcke Wolf-Dietrich, von Baehr Volker, Volk Hans-Dieter, Sabat Robert, Impaired antigen presentation by human monocytes during endotoxin tolerance, Blood, 96, 1, 2000. Crossref
-
Murad Kari L., Gosselin Edmund J., Eaton John W., Scott Mark D., Stealth Cells: Prevention of Major Histocompatibility Complex Class II-Mediated T-Cell Activation by Cell Surface Modification, Blood, 94, 6, 1999. Crossref
-
Farsaci Benedetto, Kwilas Anna, Hodge James W., Design, development, and translation of poxvirus-based vaccines for cancer, in Cancer Vaccines: From Research to Clinical Practice, 2011. Crossref
-
Palena Claudia, Foon Kenneth A., Panicali Dennis, Yafal Alicia Gómez, Chinsangaram Jarasvech, Hodge James W., Schlom Jeffrey, Tsang Kwong Y., Potential approach to immunotherapy of chronic lymphocytic leukemia (CLL): enhanced immunogenicity of CLL cells via infection with vectors encoding for multiple costimulatory molecules, Blood, 106, 10, 2005. Crossref
-
Ramkumar Poornima, Abarientos Anthony B., Tian Ruilin, Seyler Meghan, Leong Jaime T., Chen Merissa, Choudhry Priya, Hechler Torsten, Shah Nina, Wong Sandy W., Martin Thomas G., Wolf Jeffrey L., Roybal Kole T., Pahl Andreas, Taunton Jack, Wiita Arun P., Kampmann Martin, CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma, Blood Advances, 4, 13, 2020. Crossref
-
Li Yan, Zhu Min, Huo Yani, Zhang Xuerong, Liao Ming, Anti‑fibrosis activity of combination therapy with epigallocatechin gallate, taurine and genistein by regulating glycolysis, gluconeogenesis, and ribosomal and lysosomal signaling pathways in HSC‑T6 cells, Experimental and Therapeutic Medicine, 2018. Crossref
-
Khongthong Sunisa, Theapparat Yongyuth, Roekngam Natthrit, Tantisuwanno Chinnapatch, Otto Michael, Piewngam Pipat, Characterization and immunomodulatory activity of sulfated galactan from the red seaweed Gracilaria fisheri, International Journal of Biological Macromolecules, 189, 2021. Crossref
-
Vancheri Carlo, Mastruzzo Claudio, Trovato-Salinaro Elisa, Gili Elisa, Lo Furno Debora, Pistorio Maria P, Caruso Massimo, La Rosa Cristina, Crimi Claudia, Failla Marco, Crimi Nunzio, Interaction between human lung fibroblasts and T-lymphocytes prevents activation of CD4+ cells, Respiratory Research, 6, 1, 2005. Crossref
-
Gokhale Ameya, Weldeghiorghis Thomas K., Taneja Veena, Satyanarayanajois Seetharama D., Conformationally Constrained Peptides from CD2 To Modulate Protein–Protein Interactions between CD2 and CD58, Journal of Medicinal Chemistry, 54, 15, 2011. Crossref
-
Arlen Philip M, Mohebtash Mahsa, Madan Ravi A, Gulley James L, Promising novel immunotherapies and combinations for prostate cancer, Future Oncology, 5, 2, 2009. Crossref
-
Samoilova Elena B., Horton Jennifer L., Chen Youhai, Experimental Autoimmune Encephalomyelitis in Intercellular Adhesion Molecule-1-Deficient Mice, Cellular Immunology, 190, 1, 1998. Crossref
-
Al-Aghbar Mohammad Ameen, Jainarayanan Ashwin K., Dustin Michael L., Roffler Steve R., The interplay between membrane topology and mechanical forces in regulating T cell receptor activity, Communications Biology, 5, 1, 2022. Crossref
-
Raghavendra V, Singh V, Shaji A V, Vohra H, Kulkarni S K, Agrewala J N, Melatonin provides signal 3 to unprimed CD4+ T cells but failed to stimulate LPS primed B cells, Clinical and Experimental Immunology, 124, 3, 2001. Crossref
-
Li Chiang J., Ueda Yutaka, Shi Bin, Borodyansky Laura, Huang Lili, Li You-Zhi, Pardee Arthur B., Tat protein induces self-perpetuating permissivity for productive HIV-1 infection, Proceedings of the National Academy of Sciences, 94, 15, 1997. Crossref
-
Berndt Uta, Philipsen Lars, Bartsch Sebastian, Wiedenmann Bertram, Baumgart Daniel C., Hämmerle Marcus, Sturm Andreas, Systematic High-Content Proteomic Analysis Reveals Substantial Immunologic Changes in Colorectal Cancer, Cancer Research, 68, 3, 2008. Crossref
-
Morse Michael A., Clay Timothy M., Hobeika Amy C., Osada Takuya, Khan Shubi, Chui Stephen, Niedzwiecki Donna, Panicali Dennis, Schlom Jeffrey, Lyerly H. Kim, Phase I Study of Immunization with Dendritic Cells Modified with Fowlpox Encoding Carcinoembryonic Antigen and Costimulatory Molecules, Clinical Cancer Research, 11, 8, 2005. Crossref
-
SHAFIULLA Shaik, DHANESHWAR Suneela, Recent Advancements in Antipsoriatic Therapy: An Update, Fabad Journal of Pharmaceutical Sciences, 2022. Crossref
-
Consalvo Kristen M., Kirolos Sara A., Sestak Chelsea E., Gomer Richard H., Sex-Based Differences in Human Neutrophil Chemorepulsion, The Journal of Immunology, 209, 2, 2022. Crossref
-
Toor Amir A., Stiff Patrick J., Nickoloff Brian J., Rodriguez Tulio, Klein Jared L., Gordon Kenneth B., Alefacept in corticosteroid refractory graft versus host disease: Early results indicate promising activity, Journal of Dermatological Treatment, 18, 1, 2007. Crossref
-
Slavin-Chiorini Dale C, Catalfamo Marta, Kudo-Saito Chie, Hodge James W, Schlom Jeffrey, Sabzevari Helen, Amplification of the lytic potential of effector/memory CD8+ cells by vector-based enhancement of ICAM-1 (CD54) in target cells: implications for intratumoral vaccine therapy, Cancer Gene Therapy, 11, 10, 2004. Crossref
-
Dahal Achyut, Parajuli Pravin, Singh Sitanshu S., Shrestha Leeza, Sonju Jafrin Jobayer, Shrestha Prajesh, Chatzistamou Ioulia, Jois Seetharama, Targeting protein–protein interaction for immunomodulation: A sunflower trypsin inhibitor analog peptidomimetic suppresses RA progression in CIA model, Journal of Pharmacological Sciences, 149, 3, 2022. Crossref
-
Wang Xiaoping, Lewis Dorothy E., CD86 expression correlates with amounts of HIV produced by macrophages in vitro , Journal of Leukocyte Biology, 69, 3, 2001. Crossref
-
Vallée Isabelle, Guillaumin Jean-Maurice, Thibault Gilles, Gruel Yves, Lebranchu Yvon, Bardos Pierre, Watier Hervé, Human T Lymphocyte Proliferative Response to Resting Porcine Endothelial Cells Results from an HLA-Restricted, IL-10-Sensitive, Indirect Presentation Pathway But Also Depends on Endothelial-Specific Costimulatory Factors, The Journal of Immunology, 161, 4, 1998. Crossref
-
Harrop Jeremy A., Reddy Manjula, Dede Kimberly, Brigham-Burke Michael, Lyn Sally, Tan Kong B., Silverman Carol, Eichman Christopher, DiPrinzio Rocco, Spampanato Jay, Porter Terence, Holmes Stephen, Young Peter R., Truneh Alemseged, Antibodies to TR2 (Herpesvirus Entry Mediator), a New Member of the TNF Receptor Superfamily, Block T Cell Proliferation, Expression of Activation Markers, and Production of Cytokines, The Journal of Immunology, 161, 4, 1998. Crossref
-
Yin Deling, Zhang Liying, Wang Ruoxiang, Radvanyi Laszlo, Haudenschild Christian, Fang Qiding, Kehry Marilyn R., Shi Yufang, Ligation of CD28 In Vivo Induces CD40 Ligand Expression and Promotes B Cell Survival, The Journal of Immunology, 163, 8, 1999. Crossref
-
Hilliard Brendan, Samoilova Elena B., Liu Tzu-Shang T., Rostami Abdolmohamad, Chen Youhai, Experimental Autoimmune Encephalomyelitis in NF-κB- Deficient Mice: Roles of NF-κB in the Activation and Differentiation of Autoreactive T Cells, The Journal of Immunology, 163, 5, 1999. Crossref