Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Immunology
Fator do impacto: 1.404 FI de cinco anos: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472

Volumes:
Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v28.i4.10
pages 269-279

Regulation of Airway Innate and Adaptive Immune Responses: The IL-17 Paradigm

Li-Yin Hung
Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA95616
Sharlene Velichko
Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA95616
Fei Huang
Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA95616
Philip Thai
Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA95616
Reen Wu
Center for Comparative Respiratory Biology and Medicine, University of California, USA

RESUMO

IL-17 is a proinflammatory cytokine produced by immune cells. Its significance in host defense and disease development has been demonstrated in various infection and autoimmune models. Recently, additional studies have shown that IL-17 is also important in modulating airway immune response in several aspects. Along with the well-established Th1/Th2 model, new discoveries regarding the Th17 lineage and IL-17 functions have added an extra twist to the already complicated cytokine network that regulates airway immunity. The IL-17 receptor is expressed on blood cells, as well as on structural cells such as the epithelial cells in the airway. Therefore, the effect of IL-17 on airway immunity is very broad, covering both the innate and the adaptive aspects. In this review, we summarize the findings of recent studies on IL-17 signaling and function in pulmonary immune response, and the implications of IL-17 in disease pathogenesis.


Articles with similar content:

FcR-Mediated Inhibition of Cell Activation and Other Forms of Coinhibition
Critical Reviews™ in Immunology, Vol.18, 1998, issue 6
Nicholas R. StC. Sinclair, Colin C. Anderson
Induction and Regulation of T-Cell Priming for Contact Hypersensitivity
Critical Reviews™ in Immunology, Vol.21, 2001, issue 5
Anton V. Gorbachev, Robert L. Fairchild
Immune Mechanisms of Allergic Airway Disease: Regulation by Transcription Factors
Critical Reviews™ in Immunology, Vol.27, 2007, issue 6
Atsushi Onodera, Masakatsu Yamashita, Toshinori Nakayama
Function and Regulation of Retinoic Acid-Inducible Gene-I
Critical Reviews™ in Immunology, Vol.30, 2010, issue 6
Diana M. Stafforini, Tomoh Matsumiya
Eosinophils in Homeostasis and Their Contrasting Roles during Inflammation and Helminth Infections
Critical Reviews™ in Immunology, Vol.36, 2016, issue 3
Julia Strandmark, Susanne Hartmann, Sebastian Rausch