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Critical Reviews™ in Immunology
Fator do impacto: 1.404 FI de cinco anos: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2013006794
pages 57-96

Role of scavenger receptors in the pathophysiology of chronic liver diseases

Carolina Armengol
Liver Oncology Group, Health Sciences Research Institute Germans Trias i Pujol (IGTP), Badalona; Experimental Cirrhosis Group (IGTP), Badalona, Spain
Ramon Bartoli
CIBERehd, Barcelona; Experimental Cirrhosis Group (IGTP), Badalona, Spain
Lucia Sanjurjo
Innate Immunity Group (IGTP), Badalona, Spain
Isabel Serra
Liver Oncology Group, Health Sciences Research Institute Germans Trias i Pujol (IGTP), Badalona
Nuria Amezaga
Innate Immunity Group (IGTP), Badalona, Spain
Margarita Sala
Gastroenterology Service, University Hospital Germans Trias i Pujol (HGTiP), Badalona, Spain
Maria-Rosa Sarrias
Health Sciences Research Institute Germans Trias i Pujol (IGTP)

RESUMO

Scavenger receptors comprise a large family of structurally diverse proteins that are involved in many homeostatic functions. They recognize a wide range of ligands, from pathogen-associated molecular patterns (PAMPs) to endogenous, as well asmodified host-derived molecules (DAMPs). The liver deals with blood micro-organisms and DAMPs released from injured organs, thus performing vital metabolic and clearance functions that require the uptake of nutrients and toxins. Many liver cell types, including hepatocytes and Kupffer cells, express scavenger receptors that play key roles in hepatitis C virus entry, lipid uptake, and macrophage activation, among others. Chronic liver disease causes high morbidity and mortality worldwide. Hepatitis virus infection, alcohol abuse, and non-alcoholic fatty liver are the main etiologies associated with this disease. In this context, continuous inflammation as a result of liver damage leads to hepatic fibrosis, which frequently brings about cirrhosis and ultimately hepatocellular carcinoma. In this review, we will summarize the role of scavenger receptors in the pathophysiology of chronic liver diseases. We will also emphasize their potential as biomarkers of advanced liver disease, including cirrhosis and cancer.


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