Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Immunology
Fator do impacto: 1.404 FI de cinco anos: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472

Volumes:
Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2013006721
pages 23-40

T-Cell-Mediated Immunity and the Role of TRAIL in Sepsis-Induced Immunosuppression

Stephanie A. Condotta
Department of Pathology, University of Iowa, Iowa City, Iowa
Javier Cabrera-Perez
Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, Minnesota
Vladimir P. Badovinac
Department of Pathology, Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa
Thomas S. Griffith
Department of Urology, University of Minnesota, Minneapolis, MN; Microbiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN; Center for Immunology, University of Minnesota, Minneapolis, MN; Minneapolis VA Health Care System, Minneapolis, Minnesota

RESUMO

Sepsis is the leading cause of death in most intensive care units, and the death of septic patients usually does not result from the initial septic event but rather from subsequent nosocomial infections. Patients who survive severe sepsis often display severely compromised immune function. Not only is there significant apoptosis of lymphoid and myeloid cells that depletes critical components of the immune system during sepsis, there is also decreased function of the remaining immune cells. Studies of animals and humans suggest the immune defects that occur during sepsis may be critical to pathogenesis and subsequent mortality. This review focuses on sepsis-induced alterations with the cluster differentiation (CD) 8 T-cell compartment that can affect the control of secondary heterologous infections. Understanding how a septic event directly influences CD8 T-cell populations through apoptotic death and homeostatic proliferation and indirectly by immune-mediated suppression will provide valuable starting points for developing new treatment options.


Articles with similar content:

Regulation Generation: The Suppressive Functions of Human Regulatory T Cells
Critical Reviews™ in Immunology, Vol.32, 2012, issue 1
Kevin D. Cooper, Thomas S. McCormick, Wendy A. Goodman
IL-7 and Its Beneficial Role in Sepsis-Induced T Lymphocyte Dysfunction
Critical Reviews™ in Immunology, Vol.38, 2018, issue 6
Fabienne Venet, Charles de Roquetaillade, Guillaume Monneret, Morgane Gossez
Dendritic Cells in Cancer Immunotherapy
Critical Reviews™ in Immunology, Vol.21, 2001, issue 1-3
Matthias Gunzer, Stephan Grabbe
Maintenance and Attrition of T-Cell Memory
Critical Reviews™ in Immunology, Vol.23, 2003, issue 1-2
Lakshmi Krishnan, Subash Sad
Notochordal Cells in the Adult Intervertebral Disc: New Perspective on an Old Question
Critical Reviews™ in Eukaryotic Gene Expression, Vol.21, 2011, issue 1
Makarand V. Risbud, Irving M. Shapiro