Inscrição na biblioteca: Guest
Critical Reviews™ in Immunology

Publicou 6 edições por ano

ISSN Imprimir: 1040-8401

ISSN On-line: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Tumor Plasticity Interferes with Anti-Tumor Immunity

Volume 34, Edição 2, 2014, pp. 91-102
DOI: 10.1615/CritRevImmunol.2014010183
Get accessGet access

RESUMO

Since tumor cell plasticity was first shown to be crucial in tumor promotion and immune surveillance evasion, it has become an issue of intense investigation. Several mechanisms are associated with the acquisition of tumor cell plasticity and immune evasion, including loss of epithelial phenotype through epithelial-to-mesenchymal transition (EMT). We discuss recent evidence revealing that tumor cell plasticity may lead to the emergence of immunoresistant variants and how the tumor microenvironment evolves to shape this plasticity. We argue that targeting carcinoma cell plasticity represents a novel strategy to better control the emergence of resistant variants and to ensure more effective cancer therapies. In this context, the design of innovative integrative immunotherapy approaches is warranted.

CITADO POR
  1. Vuillefroy de Silly Romain, Ducimetière Laura, Yacoub Maroun Céline, Dietrich Pierre-Yves, Derouazi Madiha, Walker Paul R., Phenotypic switch of CD8+T cells reactivated under hypoxia toward IL-10 secreting, poorly proliferative effector cells, European Journal of Immunology, 45, 8, 2015. Crossref

  2. Banyard Jacqueline, Bielenberg Diane R., The role of EMT and MET in cancer dissemination, Connective Tissue Research, 56, 5, 2015. Crossref

  3. Nieto M. Angela, Huang Ruby Yun-Ju, Jackson Rebecca A., Thiery Jean Paul, EMT: 2016, Cell, 166, 1, 2016. Crossref

  4. Dominguez Charli, Tsang Kwong-Yok, Palena Claudia, Short-term EGFR blockade enhances immune-mediated cytotoxicity of EGFR mutant lung cancer cells: rationale for combination therapies, Cell Death & Disease, 7, 9, 2016. Crossref

  5. Ferreira Bibiana I., Lie Maria K., Engelsen Agnete S. T., Machado Susana, Link Wolfgang, Lorens James B., Adaptive mechanisms of resistance to anti-neoplastic agents, MedChemComm, 8, 1, 2017. Crossref

  6. Janji Bassam, Viry Elodie, Mgrditchian Takouhie, Arakelian Tsolere, Medves Sandrine, Berchem Guy, Autophagy Activation in the Tumor Microenvironment, in Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 2016. Crossref

  7. Iser Isabele C., Pereira Mariana B., Lenz Guido, Wink Márcia R., The Epithelial-to-Mesenchymal Transition-Like Process in Glioblastoma: An Updated Systematic Review and In Silico Investigation, Medicinal Research Reviews, 37, 2, 2017. Crossref

  8. Raimondi Cristina, Carpino Guido, Nicolazzo Chiara, Gradilone Angela, Gianni Walter, Gelibter Alain, Gaudio Eugenio, Cortesi Enrico, Gazzaniga Paola, PD-L1 and epithelial-mesenchymal transition in circulating tumor cells from non-small cell lung cancer patients: A molecular shield to evade immune system?, OncoImmunology, 6, 12, 2017. Crossref

  9. Lindsay Danika, Garvey Colleen M., Mumenthaler Shannon M., Foo Jasmine, The Response of Cancer Cell Populations to Therapies, in Ecology and Evolution of Cancer, 2017. Crossref

  10. Vanneste Marion, Henry Michael D., Targeting Phenotypic Plasticity in Prostate Cancer, Current Molecular Biology Reports, 3, 3, 2017. Crossref

  11. Ziani Linda, Chouaib Salem, Thiery Jerome, Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts, Frontiers in Immunology, 9, 2018. Crossref

  12. Lachat Camille, Boyer-Guittaut Michaël, Peixoto Paul, Hervouet Eric, Epigenetic Regulation of EMT (Epithelial to Mesenchymal Transition) and Tumor Aggressiveness: A View on Paradoxical Roles of KDM6B and EZH2, Epigenomes, 3, 1, 2018. Crossref

  13. Engl Wilfried, Viasnoff Virgile, Thiery Jean Paul, Epithelial Mesenchymal Transition Influence on CTL Activity, in Resistance of Cancer Cells to CTL-Mediated Immunotherapy, 7, 2015. Crossref

  14. Soundararajan Rama, Fradette Jared, Konen Jessica, Moulder Stacy, Zhang Xiang, Gibbons Don, Varadarajan Navin, Wistuba Ignacio, Tripathy Debasish, Bernatchez Chantale, Byers Lauren, Chang Jeffrey, Contreras Alejandro, Lim Bora, Parra Edwin, Roarty Emily, Wang Jing, Yang Fei, Barton Michelle, Rosen Jeffrey, Mani Sendurai, Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy, Cancers, 11, 5, 2019. Crossref

  15. Hasmim Meriem, Messai Yosra, Terry Stéphane, Janji Bassam, Noman Muhammad Zaeem, Chouaib Salem, Hypoxia: A Formidable Saboteur of the Anti-tumor Response, in Resistance of Cancer Cells to CTL-Mediated Immunotherapy, 7, 2015. Crossref

  16. Noman Muhammad Zaeem, Hasmim Meriem, Lequeux Audrey, Xiao Malina, Duhem Caroline, Chouaib Salem, Berchem Guy, Janji Bassam, Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges, Cells, 8, 9, 2019. Crossref

  17. Manjunath Yariswamy, Upparahalli Sathisha V., Avella Diego M., Deroche Chelsea B., Kimchi Eric T., Staveley-O’Carroll Kevin F., Smith Charles J., Li Guangfu, Kaifi Jussuf T., PD-L1 Expression with Epithelial Mesenchymal Transition of Circulating Tumor Cells Is Associated with Poor Survival in Curatively Resected Non-Small Cell Lung Cancer, Cancers, 11, 6, 2019. Crossref

  18. Behren Andreas, Thompson Erik W., Anderson Robin L., Ferrao Petranel T., Editorial: Cancer Plasticity and the Microenvironment: Implications for Immunity and Therapy Response, Frontiers in Oncology, 9, 2019. Crossref

  19. Janji Bassam, Viry Elodie, Moussay Etienne, Paggetti Jérôme, Arakelian Tsolère, Mgrditchian Takouhie, Messai Yosra, Noman Muhammad Zaeem, Van Moer Kris, Hasmim Meriem, Mami-Chouaib Fathia, Berchem Guy, Chouaib Salem, The multifaceted role of autophagy in tumor evasion from immune surveillance, Oncotarget, 7, 14, 2016. Crossref

  20. Lim Jaeseung, Harnessing Natural Killer Cells’ Killing Function in Cancer, in Second Generation Cell and Gene-based Therapies, 2020. Crossref

  21. Genna Anthony, Vanwynsberghe Aline M., Villard Amélie V., Pottier Charles, Ancel Julien, Polette Myriam, Gilles Christine, EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis, Cancers, 12, 6, 2020. Crossref

  22. Tittarelli Andrés, Navarrete Mariela, Lizana Marcelo, Hofmann-Vega Francisca, Salazar-Onfray Flavio, Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 Channels, International Journal of Molecular Sciences, 21, 20, 2020. Crossref

  23. Richter Camden, Mayhew David, Rennhack Jonathan P., So Jonathan, Stover Elizabeth H., Hwang Justin H., Szczesna-Cordary Danuta, Genomic Amplification and Functional Dependency of the Gamma Actin Gene ACTG1 in Uterine Cancer, International Journal of Molecular Sciences, 21, 22, 2020. Crossref

  24. Bravaccini Sara, Bronte Giuseppe, Petracci Elisabetta, Puccetti Maurizio, D’Arcangelo Manolo, Ravaioli Sara, Tumedei Maria Maddalena, Maltoni Roberta, Delmonte Angelo, Cappuzzo Federico, Crinò Lucio, The Expression of Programmed Death Ligand 1 and Vimentin in Resected Non-Metastatic Non-Small-Cell Lung Cancer: Interplay and Prognostic Effects, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref

  25. Wu Tiantian, Tang Caijin, Tao Renchuan, Yong Xiangzhi, Jiang Qiaozhi, Feng Cong, PD-L1-Mediated Immunosuppression in Oral Squamous Cell Carcinoma: Relationship With Macrophage Infiltration and Epithelial to Mesenchymal Transition Markers, Frontiers in Immunology, 12, 2021. Crossref

  26. Drak Alsibai Kinan, Cancer Metabolic and Immune Reprogramming: The Intimate Interaction Between Cancer Cells and Microenvironment, Journal of Cancer Prevention & Current Research, 1, 2, 2014. Crossref

  27. Bronte Giuseppe, Puccetti Maurizio, Petracci Elisabetta, Landi Lorenza, Cravero Paola, Scodes Simona, Ulivi Paola, Ravaioli Sara, Tumedei Maria Maddalena, Burgio Marco Angelo, Cappuzzo Federico, Delmonte Angelo, Crinò Lucio, Bravaccini Sara, The Interplay Between Programmed Death Ligand 1 and Vimentin in Advanced Non-Small-Cell Lung Cancer, Frontiers in Oncology, 11, 2021. Crossref

  28. Tittarelli Andrés, Janji Bassam, Van Moer Kris, Noman Muhammad Zaeem, Chouaib Salem, The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing, Journal of Biological Chemistry, 290, 39, 2015. Crossref

  29. Lin Huey-Jen, Liu Yingguang, Lofland Denene, Lin Jiayuh, Breast Cancer Tumor Microenvironment and Molecular Aberrations Hijack Tumoricidal Immunity, Cancers, 14, 2, 2022. Crossref

  30. Tripathi Satyendra C., Peters Haley L., Taguchi Ayumu, Katayama Hiroyuki, Wang Hong, Momin Amin, Jolly Mohit Kumar, Celiktas Muge, Rodriguez-Canales Jaime, Liu Hui, Behrens Carmen, Wistuba Ignacio I., Ben-Jacob Eshel, Levine Herbert, Molldrem Jeffrey J., Hanash Samir M., Ostrin Edwin J., Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome, Proceedings of the National Academy of Sciences, 113, 11, 2016. Crossref

  31. Ge Yang, Liu Heshu, Zhang Yuanyuan, Liu Jian, Yan Rui, Xiao Zeru, Fan Xiaona, Huang Xuying, An Guangyu, Inhibition of DCLK1 kinase reverses epithelial-mesenchymal transition and restores T-cell activity in pancreatic ductal adenocarcinoma, Translational Oncology, 17, 2022. Crossref

  32. Saxena Kritika, Subbalakshmi Ayalur Raghu, Kulkarni Prakash, Jolly Mohit Kumar, Cancer: More than a geneticist’s Pandora’s box, Journal of Biosciences, 47, 2, 2022. Crossref

  33. Lotsberg Maria L., Davidsen Kjersti T., D’Mello Peters Stacey, Haaland Gry S., Rayford Austin, Lorens James B., Engelsen Agnete S. T., The Role of AXL Receptor Tyrosine Kinase in Cancer Cell Plasticity and Therapy Resistance, in Biomarkers of the Tumor Microenvironment, 2022. Crossref

  34. Chen Gaoqi, Wu Kaiwen, Li Hao, Xia Demeng, He Tianlin, Role of hypoxia in the tumor microenvironment and targeted therapy, Frontiers in Oncology, 12, 2022. Crossref

Próximos artigos

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa Políticas de preços e assinaturas Begell House Contato Language English 中文 Русский Português German French Spain