Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
Indexed in
Immunomodulation of Experimental Autoimmune Diseases via Oral Tolerance
RESUMO
The concept of oral tolerance refers to a form of peripheral tolerance in which mature lymphocytes in the peripheral lymphoid tissues are rendered nonfunctional or hyporesponsive by prior oral administration of an antigen. The primary mechanisms mediating oral tolerance include deletion, anergy of antigen-specific T cells and active cellular suppression, the primary determining factor being the dose of fed antigen. Low doses favor active suppression, whereas high doses favor deletion and anergy. Active cellular suppression is mediated by the induction of regulatory T cells in the gut-associated lymphoid tissue, which migrate to the systemic immune system. One of the primary mechanisms of active cellular suppression is via secretion of suppressive cytokines such as TGF-β, IL-4, and IL-10 following antigen-specific triggering. TGF-β is produced both by CD4+ and CD8+ GALT-derived T cells and is an important mediator of the active suppression component of oral tolerance. CD4+ cells that primarily produce TGF-β appear to be a unique T-cell subset and termed Th3 cells. Oral tolerance was successfully studied in a variety of experimental models for autoimmune diseases, among them experimental autoimmune encephalomyelitis, experimental arthritis, experimental anti-phospholipid syndrome, experimental autoimmune uveoretinitis, experimental insulin dependent diabetes mellitus (IDDM), and experimental autoimmune myasthenia gravis. The results obtained in experimental animal models have led to the conduction of several clinical trials of oral tolerance in patients with multiple sclerosis, rheumatoid arthritis, uveitis, and IDDM. Conflicting results were obtained, and although some improvement has been noted in some of the patients, broad ranging clinical improvement has not yet been observed. A more accurate choice of antigens, as well as more precise dosing and timing of antigen-administration might lead to better results in the future.
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HARRISON LEONARD C., Prevention of Autoimmune Disease: Type 1 Diabetes as a Paradigm, in The Autoimmune Diseases, 2006. Crossref
-
Abu-Shakra Mahmoud, Shoenfeld Yehuda, Lessons from Monoclonal Antiphospholipid Antibodies, in The Antiphospholipid Syndrome II, 2002. Crossref
-
Martinez Nathan R., Augstein Petra, Moustakas Antonis K., Papadopoulos George K., Gregori Silvia, Adorini Luciano, Jackson David C., Harrison Leonard C., Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide, Journal of Clinical Investigation, 111, 9, 2003. Crossref
-
Cohen-Kaminsky Sylvia, Jambou Florence, Prospects for a T-cell receptor vaccination against myasthenia gravis, Expert Review of Vaccines, 4, 4, 2005. Crossref
-
Iijima Hideki, Takahashi Ichiro, Kiyono Hiroshi, Mucosal immune network in the gut for the control of infectious diseases, Reviews in Medical Virology, 11, 2, 2001. Crossref
-
Krause Ilan, Blank Miri, Sherer Yaniv, Gilburd Boris, Kvapil Filip, Shoenfeld Yehuda, Induction of oral tolerance in experimental antiphospholipid syndrome by feeding with polyclonal immunoglobulins, European Journal of Immunology, 32, 12, 2002. Crossref
-
Martinez Nathan R., Augstein Petra, Moustakas Antonis K., Papadopoulos George K., Gregori Silvia, Adorini Luciano, Jackson David C., Harrison Leonard C., Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide, Journal of Clinical Investigation, 111, 9, 2003. Crossref
-
LUO C., LAINE V. J. O., YLINEN L., TEROS T., MÄKINEN M., RISTIMÄKI A., SIMELL O., Expression of cyclooxygenase-2 in intestinal goblet cells of pre-diabetic NOD mice, Acta Physiologica Scandinavica, 174, 3, 2002. Crossref
-
Bregenholt S., Wang M., Wolfe T., Hughes A., Baerentzen L., Dyrberg T., von Herrath M. G., Petersen J. S., The Cholera Toxin B Subunit is a Mucosal Adjuvant for Oral Tolerance Induction in Type 1 Diabetes, Scandinavian Journal of Immunology, 57, 5, 2003. Crossref
-
SHOENFELD Yehuda, Autoimmune aspects of accelerated atherosclerosis in rheumatology, APLAR Journal of Rheumatology, 7, 3, 2004. Crossref
-
STAINES NORMAN A., DERRY CATHERINE J., MARINOVA-MUTAFCHIEVA LILIA, ALI NADIRA, DAVIES D HUW, MURPHY JOHN J., Constraints on the Efficacy of Mucosal Tolerance in Treatment of Human and Animal Arthritic Diseases, Annals of the New York Academy of Sciences, 1029, 1, 2004. Crossref
-
Harrison Leonard C., Wentworth John M., Prevention of Autoimmune Disease, in The Autoimmune Diseases, 2014. Crossref
-
Antiga E., Quaglino P., Bellandi S., Volpi W., Del Bianco E., Comessatti A., Osella-Abate S., De Simone C., Marzano A., Bernengo M.G., Fabbri P., Caproni M., Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea, British Journal of Dermatology, 162, 5, 2010. Crossref
-
Dreyfus David H., Autoimmune disease: A role for new anti-viral therapies?, Autoimmunity Reviews, 11, 2, 2011. Crossref
-
McHugh Rebecca S., Shevach Ethan M., Thornton Angela M., Control of organ-specific autoimmunity by immunoregulatory CD4+CD25+ T cells, Microbes and Infection, 3, 11, 2001. Crossref
-
Spiekermann Gerburg M., Walker W. Allan, Oral Tolerance and Its Role in Clinical Disease, Journal of Pediatric Gastroenterology and Nutrition, 32, 3, 2001. Crossref
-
Thurau Stephan R, Wildner Gerhild, Oral tolerance for treating uveitis — new hope for an old immunological mechanism, Progress in Retinal and Eye Research, 21, 6, 2002. Crossref
-
Vallochi Adriana L., Commodaro Alessandra G., Schwartzman Jean P., Belfort Rubens, Rizzo Luiz V., The role of cytokines in the regulation of ocular autoimmune inflammation, Cytokine & Growth Factor Reviews, 18, 1-2, 2007. Crossref
-
Seo Naohiro, Hayakawa Satoshi, Tokura Yoshiki, Mechanisms of immune privilege for tumor cells by regulatory cytokines produced by innate and acquired immune cells, Seminars in Cancer Biology, 12, 4, 2002. Crossref
-
Harrison Leonard C, Hafler David A, Antigen-specific therapy for autoimmune disease, Current Opinion in Immunology, 12, 6, 2000. Crossref
-
Boyd Shelley Romayne, Young Stephanie, Lightman Susan, Immunopathology of the Noninfectious Posterior and Intermediate Uveitides, Survey of Ophthalmology, 46, 3, 2001. Crossref
-
TePas Elizabeth C., Hoyte Elisabeth G., McIntire Jennifer J., Umetsu Dale T., Clinical efficacy of microencapsulated timothy grass pollen extract in grass-allergic individuals, Annals of Allergy, Asthma & Immunology, 92, 1, 2004. Crossref
-
Raithel Martin, Weidenhiller Michael, Hahn Markus, Hagel Alexander, Bechthold Caroline, Neurath Markus F., Rieker Ralf J., Stein Jürgen, Primary Manifestation of Inflammatory Bowel Disease Following Subcutaneous Autovaccination, Journal of Crohn's and Colitis, 9, 9, 2015. Crossref
-
Stein-Streilein Joan, Immune regulation and the eye, Trends in Immunology, 29, 11, 2008. Crossref
-
Gorczynski R.M., Alexander C., Bessler W., Brandenburg K., Fournier K., Mach J.P., Mueller S., Rietschel E.Th., Ulmer A.J., Waelli Th., Zahringer U., Khatri I., An alteration in the levels of populations of CD4+ Treg is in part responsible for altered cytokine production by cells of aged mice which follows injection with a fetal liver extract, Immunology Letters, 109, 2, 2007. Crossref
-
Shi Tianyun, He Yanchao, Sun Wei, Wu Yi, Li Ling, Jie Zhijun, Su Xiao, Respiratory Syncytial virus infection compromises asthma tolerance by recruiting interleukin-17A-producing cells via CCR6-CCL20 signaling, Molecular Immunology, 88, 2017. Crossref
-
Ayada K., Yokota K., Hirai K., Fujimoto K., Kobayashi K., Ogawa H., Hatanaka K., Hirohata S., Yoshino T., Shoenfeld Y., Matsuura E., Oguma K., Regulation of cellular immunity prevents Helicobacter pylori-induced atherosclerosis, Lupus, 18, 13, 2009. Crossref
-
de Oliveira Sandra R. P., Nomizo Auro, Frantz Fabiani G., Faccioli Lúcia H., Matos Ana Paula Keller de, Carrilho Emanuel, Afonso Ana, de Freitas Anibal Fernanda, Participation of Leukotrienes in the Immune Modulation of Oral Tolerance, Frontiers in Microbiology, 8, 2017. Crossref
-
Finamore Alberto, Roselli Marianna, Merendino Nicolò, Nobili Fabio, Vignolini Francesco, Mengheri Elena, Zinc Deficiency Suppresses the Development of Oral Tolerance in Rats, The Journal of Nutrition, 133, 1, 2003. Crossref
-
Winter William E., Schatz Desmond, Prevention Strategies for Type 1 Diabetes Mellitus, BioDrugs, 17, 1, 2003. Crossref
-
McHugh R. S., Autoimmune Gastritis Is a Well-Defined Autoimmune Disease Model for the Study of CD4+CD25+ T Cell-Mediated Suppression, in CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential, 293, 2005. Crossref
-
Ansari Aftab A., Pattanapanyasat Kovit, Immunological Tolerance in Allo- and Xenografts, in Liver Immunology, 2007. Crossref
-
Wynn Susan G., Marsden Steve, Therapies for Endocrinologic Disorders, in Manual of Natural Veterinary Medicine, 2003. Crossref
-
Peine Kevin J., Guerau-de-Arellano Mireia, Lee Priscilla, Kanthamneni Naveen, Severin Mary, Probst G. Duane, Peng Haiyan, Yang Yuhong, Vangundy Zachary, Papenfuss Tracey L., Lovett-Racke Amy E., Bachelder Eric M., Ainslie Kristy M., Treatment of Experimental Autoimmune Encephalomyelitis by Codelivery of Disease Associated Peptide and Dexamethasone in Acetalated Dextran Microparticles, Molecular Pharmaceutics, 11, 3, 2014. Crossref
-
Harrison Leonard C., Wentworth John M., Prevention of Autoimmune Disease: The Type 1 Diabetes Paradigm, in The Autoimmune Diseases, 2020. Crossref
-
Sviridova V. S., Коlogrivova Ye. N., Pronina N. A., Yeliseyeva L. V., Chitalkina A. A., Т lymphocytes are key immune regulating cells, Bulletin of Siberian Medicine, 6, 1, 2007. Crossref
-
Kitamei Hirokuni, Kitaichi Nobuyoshi, Yoshida Kazuhiko, Nakai Akira, Fujimoto Mitsuaki, Kitamura Mizuki, Iwabuchi Kazuya, Miyazaki Akiko, Namba Kenichi, Ohno Shigeaki, Onoé Kazunori, Association of heat shock protein 70 induction and the amelioration of experimental autoimmune uveoretinitis in mice, Immunobiology, 212, 1, 2007. Crossref
-
BARTH H, BERG P A, KLEIN R, Methods for the in vitro determination of an individual disposition towards TH1- or TH2-reactivity by the application of appropriate stimulatory antigens, Clinical and Experimental Immunology, 134, 1, 2003. Crossref
-
Parekh Vrajesh V., Prasad Durbaka V. R., Banerjee Pinaki P., Joshi Bimba N., Kumar Anil, Mishra Gyan C., B Cells Activated by Lipopolysaccharide, But Not By Anti-Ig and Anti-CD40 Antibody, Induce Anergy in CD8+ T Cells: Role of TGF-β1, The Journal of Immunology, 170, 12, 2003. Crossref