Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
Genetic Requirements for the Development and Differentiation of lnterleukin-17-Producing γδ T Cells
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RESUMO
Most effector T cells are generated in the periphery following an encounter with a foreign antigen and exposure to soluble and membrane-bound mediators. There are, however, some T cell subsets, such as γδ T cells and natural killer T cells, that acquire their effector potential in the thymus before their emigration to the periphery. This developmental preprogramming enables these cells to differentiate rapidly into cytokine-producing effectors during the host immune response. This review focuses on murine interleukin (IL)-17−producing γδ T (γδ-17) cells, which have been shown, through their early production of IL-17, to have a critical role in multiple infectious and autoimmune diseases. Specifically, we discuss what is currently known about the genetic requirements for their generation and compare it with what is known about that of the more extensively studied IL-17−producing helper T (Thl7) cells. Based on this comparison, we propose a model for murine γδ-17 development and differentiation.
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Braza Mounia S., Klein Bernard, Anti-tumour immunotherapy with Vγ9Vδ2 T lymphocytes: from the bench to the bedside, British Journal of Haematology, 160, 2, 2013. Crossref
-
Chien Yueh-hsiu, Zeng Xun, Prinz Immo, The natural and the inducible: interleukin (IL)-17-producing γδ T cells, Trends in Immunology, 34, 4, 2013. Crossref
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Akitsu Aoi, Ishigame Harumichi, Kakuta Shigeru, Chung Soo-hyun, Ikeda Satoshi, Shimizu Kenji, Kubo Sachiko, Liu Yang, Umemura Masayuki, Matsuzaki Goro, Yoshikai Yasunobu, Saijo Shinobu, Iwakura Yoichiro, IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells, Nature Communications, 6, 1, 2015. Crossref
-
Patil Rushikesh S., Bhat Sajad A., Dar Asif A., Chiplunkar Shubhada V., The Jekyll and Hyde story of IL17-Producing γδT Cells, Frontiers in Immunology, 6, 2015. Crossref
-
Cook Donald N., Kang Hong Soon, Jetten Anton M., Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism, Nuclear Receptor Research, 2, 2015. Crossref
-
Kulida L. V., Peretyatko L. P., Nazarov S. B., Morphogenesis of human fetal thymus during weeks 22–27 of development, Russian Journal of Developmental Biology, 46, 4, 2015. Crossref
-
Jouan Youenn, Patin Emmanuel C., Hassane Maya, Si-Tahar Mustapha, Baranek Thomas, Paget Christophe, Thymic Program Directing the Functional Development of γδT17 Cells, Frontiers in Immunology, 9, 2018. Crossref
-
Ribot Julie C., Silva-Santos Bruno, Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors, in Crossroads Between Innate and Adaptive Immunity IV, 785, 2013. Crossref
-
Khmara T. V., Zamorskii I. I., Ryznychuk М. A., Hinhuliak М. H., Khlunovska L. Yu., Kavun М. P., Structural Organization of the Thymus in 7-10-Month-Old Human Fetuses, Ukraïnsʹkij žurnal medicini, bìologìï ta sportu, 4, 2, 2019. Crossref
-
O’Brien Rebecca L., Born Willi K., Two functionally distinct subsets of IL‐17 producing γδ T cells, Immunological Reviews, 298, 1, 2020. Crossref
-
Cossu Davide, Masala Speranza, Sechi Leonardo A, A Sardinian map for multiple sclerosis, Future Microbiology, 8, 2, 2013. Crossref
-
Yun Xinming, Fang Yulai, Lv Changjun, Qiao Simiao, Tao Yu, Dai Yue, Xia Yufeng, Inhibition of the activation of γδT17 cells through PPARγ–PTEN/Akt/GSK3β/NFAT pathway contributes to the anti-colitis effect of madecassic acid, Cell Death & Disease, 11, 9, 2020. Crossref
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Chien Yueh-hsiu, Meyer Christina, Bonneville Marc, γδ T Cells: First Line of Defense and Beyond, Annual Review of Immunology, 32, 1, 2014. Crossref