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Critical Reviews™ in Immunology
Fator do impacto: 1.352 FI de cinco anos: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2013007453
pages 283-306

Which Immune Cells Matter? The Immunopathogenesis of Multiple Sclerosis

Bieke Broux
Hasselt University, Biomedical Research Institute and transnationale Universiteit Limburg, School of Life Sciences, 3590 Diepenbeek, Belgium
Piet Stinissen
Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium
Niels Hellings
Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium

RESUMO

Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is believed to be immune-mediated. While CD4+ T cells have been the main suspects for years, there is ample evidence that other immune cells (including those of the innate immune system) play a contributing or regulating role in this disease. After a general introduction, this review focuses on different immune cell subsets implicated in MS pathogenesis and on current and future possibilities to target them for therapeutic use.


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