Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
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Accessory Molecule and Costimulation Requirements for CD4 T Cell Response
RESUMO
T cell activation is brought about by recognition of peptide/MHC complexes on an antigen-presenting cell (APC) by the T cell receptor (TCR). However, in general this appears to be insufficient for the full development of T cell responses and therefore additional signals are required, provided by ligation of counter-receptors on the T cell by APC accessory molecules. Although many studies have suggested that B7 molecules (CD80/CD86) binding to CD28 induce this second signal, it is now evident that any one of a number of molecules may provide accessory function and that efficient response is only generated following multiple interactions. It has also become clear that T cells exist in varying states of activation or differentiation, and that requirements for accessory molecules and costimuli are not always equivalent. This review covers much of the recent data regarding accessory molecule regulation of T cell responses. A modified version of the two signal model is presented, suggesting that the major function of accessory molecules during the initial stages of activation is to augment the ability to signal through the TCR, and that the primary role of costimulatory signals is to allow IL-2 secretion and growth. The requirement for multiple accessory molecule interactions is discussed in relation to activation of naive T cells and how such interactions are less critical at the memory and effector stages. Finally, this new information is related to how T cells interact with varying APC and how these interactions may modulate T cell response.
-
Watson Andrew R.O., Janik David K., Lee William T., Superantigen-induced CD4 memory T cell anergy. I. Staphylococcal enterotoxin B induces Fyn-mediated negative signaling, Cellular Immunology, 276, 1-2, 2012. Crossref
-
Hewson Tim, Lone Nazir, Moore Marilyn, Howie Sarah, Interactions of HIV-1 with antigen-presenting cells, Immunology and Cell Biology, 77, 4, 1999. Crossref
-
Esmaeili Arash, Dadkhahfar Sahar, Fadakar Kaveh, Rezaei Nima, Post-Stroke Immunodeficiency: Effects of Sensitization and Tolerization to Brain Antigens, International Reviews of Immunology, 31, 5, 2012. Crossref
-
Weng Zhiping, DeLisi Charles, Toward a predictive understanding of molecular recognition, Immunological Reviews, 163, 1, 1998. Crossref
-
Huber S.A., Gauntt C.J., Sakkinen P., , 51, 1998. Crossref
-
Schaible Ulrich E., Collins Helen L., Kaufmann Stefan H.E., , 71, 1998. Crossref
-
Altman Amnon, Deckert Marcel, , 72, 1999. Crossref
-
Katamay Robert, Nussenblatt Robert B., Blood–Retinal Barrier, Immune Privilege, and Autoimmunity, in Retina, 2013. Crossref
-
Steele Timothy A., Recent Developments in the Virus Therapy of Cancer, Proceedings of the Society for Experimental Biology and Medicine, 223, 2, 2000. Crossref
-
Kohlmeier Jacob E., Rumsey Lisa M., Chan Marcia A., Benedict Stephen H., The outcome of T-cell costimulation through intercellular adhesion molecule-1 differs from costimulation through leucocyte function-associated antigen-1, Immunology, 108, 2, 2003. Crossref
-
Vakkila J., Äystö S., Saarinen-Pihkala U. M., Sariola H., Naive CD4+ T Cells Can be Sensitized with IL-7, Scandinavian Journal of Immunology, 54, 5, 2001. Crossref
-
Assing K., Nielsen C. H., Poulsen L. K., Immunological characteristics of subjects with asymptomatic skin sensitization to birch and grass pollen, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, 36, 3, 2006. Crossref
-
Milon Genevieve, Listeria monocytogenes in laboratory mice: a model of short-term infectious and pathogenic processes controllable by regulated protective immune responses, Immunological Reviews, 158, 1, 1997. Crossref
-
Caulfield , Fernandez , Sousa , Lane , Lee , Hawrylowicz , Regulation of major histocompatibility complex class II antigens on human alveolar macrophages by granulocyte-macrophage colony-stimulating factor in the presence of glucocorticoids, Immunology, 98, 1, 1999. Crossref
-
Castiglioni Paola, Gerloni Mara, Cortez-Gonzalez Xochitl, Zanetti Maurizio, CD8 T cell priming by B lymphocytes is CD4 help dependent, European Journal of Immunology, 35, 5, 2005. Crossref
-
Linton Phyllis-Jean, Haynes Laura, Tsui Lisa, Zhang Xiaohong, Swain Susan, From naive to effector - alterations with aging, Immunological Reviews, 160, 1, 1997. Crossref
-
Ohtani Haruo, Pathophysiologic Significance of Host Reactions in Human Cancer Tissue: Desmoplasia and Tumor Immunity., The Tohoku Journal of Experimental Medicine, 187, 3, 1999. Crossref
-
Roos , Claessen , Schilder-Tol , Weening , Aten , Differential Expression of T-Cell Adhesion Molecules and LFA-1-Dependent Intercellular Adhesion in HgCl2-Induced Autoimmunity and Immune Suppression, Scandinavian Journal of Immunology, 48, 4, 1998. Crossref
-
Becker Kyra J, Kindrick Darin L, Lester Mark P, Shea Connor, Ye Zu-Cheng, Sensitization to Brain Antigens after Stroke is Augmented by Lipopolysaccharide, Journal of Cerebral Blood Flow & Metabolism, 25, 12, 2005. Crossref
-
Zhai Yong-Zhen, Zhou Yan, Ma Li, Feng Guo-He, The dominant roles of ICAM-1-encoding gene in DNA vaccination against Japanese encephalitis virus are the activation of dendritic cells and enhancement of cellular immunity, Cellular Immunology, 281, 1, 2013. Crossref
-
Viñas Odette, Bataller Ramón, Sancho-Bru Pau, Ginès Pere, Berenguer Cristina, Enrich Carlos, Nicolás Josep M., Ercilla Guadalupe, Gallart Teresa, Vives Jordi, Arroyo Vicente, Rodés Juan, Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation, Hepatology, 38, 4, 2003. Crossref
-
Pinto Antonio, Gattei Valter, Zagonel Vittorina, Aldinucci Donatella, Degan Massimo, De Iuliis Angela, Rossi Francesca Maria, Mazzocco Francesca Tassan, Godeas Cristiana, Rupolo Maurizio, Poletto Dalisa, Gloghini Annunziata, Carbone Antonino, Gruss Hans-Jürgen, Hodgkin’s disease: A disorder of dysregulated cellular cross-talk, Biotherapy, 10, 4, 1998. Crossref
-
Kammerer Robert, Hahn Stefan, Singer Bernhard B., Jian S. , Luo , von Kleist Sabine, Biliary glycoprotein (CD66a), a cell adhesion molecule of the immunoglobulin superfamily, on human lymphocytes: structure, expression and involvement in T cell activation, European Journal of Immunology, 28, 11, 1998. Crossref
-
Roberts Lynden J., Baldwin Tracey M., Speed Terence P., Handman Emanuela, Foote Simon J., Chromosomes X, 9, and the H2 locus interact epistatically to controlLeishmania major infection, European Journal of Immunology, 29, 9, 1999. Crossref
-
Manjuck Janice, Saha Dhanonjoy C., Astiz Mark, Eales Lesley-Jane, Rackow Eric C., Decreased response to recall antigens is associated with depressed costimulatory receptor expression in septic critically ill patients, Journal of Laboratory and Clinical Medicine, 135, 2, 2000. Crossref
-
Lim Wee-Kiak, Nussenblatt Robert B., Retinal Autoimmunity, in Retina, 2006. Crossref
-
Swain Susan L., Agrewala Javed N., Brown Deborah M., Jelley‐Gibbs Dawn M., Golech Susanne, Huston Gail, Jones Stephen C., Kamperschroer Cris, Lee Won‐Ha, McKinstry K. Kai, Román Eulogia, Strutt Tara, Weng Nan‐ping, CD4 + T‐cell memory: generation and multi‐faceted roles for CD4 + T cells in protective immunity to influenza , Immunological Reviews, 211, 1, 2006. Crossref
-
Ilarraza Ramses, Wu Yingqi, Skappak Christopher D., Ajamian Farnam, Proud David, Adamko Darryl J., Rhinovirus has the unique ability to directly activate human T cells in vitro, Journal of Allergy and Clinical Immunology, 131, 2, 2013. Crossref
-
Joseph Sean B., Miner Kent T., Croft Michael, Augmentation of naive, Th1 and Th2 effector CD4 Responses by IL-6, IL-1 and TNF, European Journal of Immunology, 28, 1, 1998. Crossref
-
Jenski Laura J., Scherer John M., Caldwell LaDawn D., Ney Victori A., Stillwell William, The triggering signal dictates the effect of docosahexaenoic acid on lymphocyte function in vitro, Lipids, 33, 9, 1998. Crossref
-
Heinzelmann Michael, Polk Hiram C, Chernobelsky Alexander, Stites Thomas P, Gordon Laura E, Endotoxin and muramyl dipeptide modulate surface receptor expression on human mononuclear cells, Immunopharmacology, 48, 2, 2000. Crossref
-
Sakamoto Shinji, Tezuka Katsunari, Tsuji Takashi, Hori Nobuaki, Tamatani Takuya, AILIM/ICOS: Its Expression and Functional Analysis with Monoclonal Antibodies, Hybridoma and Hybridomics, 20, 5-6, 2001. Crossref
-
Ahmadi Tahamtan, Flies Amanda, Efebera Yvonne, Sherr David H., CD40 Ligand-activated, antigen-specific B cells are comparable to mature dendritic cells in presenting protein antigens and major histocompatibility complex class I- and class II-binding peptides, Immunology, 124, 1, 2008. Crossref
-
Fassò Marcella, Anandasabapathy Niroshana, Crawford Frances, Kappler John, Fathman C. Garrison, Ridgway William M., T Cell Receptor (Tcr)-Mediated Repertoire Selection and Loss of Tcr Vβ Diversity during the Initiation of a Cd4+ T Cell Response in Vivo, Journal of Experimental Medicine, 192, 12, 2000. Crossref
-
Spack Edward G., Wehner Nancy G., Winkelhake Jeffrey L., Preclinical and Pharmacological Studies of AG284, a Soluble HLA-DR2:Myelin Basic Protein Peptide Complex for the Treatment of Multiple Sclerosis, CNS Drug Reviews, 4, 3, 1998. Crossref
-
Kim Jong J., Tsai Anthony, Nottingham Liesl K., Morrison Lake, Cunning Devin M., Oh Jim, Lee Daniel J., Dang Kesen, Dentchev Tzvete, Chalian Ara A., Agadjanyan Michael G., Weiner David B., Intracellular adhesion molecule-1 modulates β-chemokines and directly costimulates T cells in vivo, Journal of Clinical Investigation, 103, 6, 1999. Crossref
-
Zierath Dannielle, Thullbery Matthew, Hadwin Jessica, Gee J. Michael, Savos Anna, Kalil Angela, Becker Kyra J., CNS Immune Responses Following Experimental Stroke, Neurocritical Care, 12, 2, 2010. Crossref
-
Steele Timothy A., Recent Developments in the Virus Therapy of Cancer, Proceedings of the Society for Experimental Biology and Medicine, 223, 2, 2008. Crossref
-
Jin Guang-Bi, Moore Amanda J., Head Jennifer L., Neumiller Joshua J., Lawrence B. Paige, Aryl Hydrocarbon Receptor Activation Reduces Dendritic Cell Function during Influenza Virus Infection, Toxicological Sciences, 116, 2, 2010. Crossref
-
Jelley‐Gibbs Dawn M, Strutt Tara M, McKinstry K Kai, Swain Susan L, Influencing the fates of CD4 T cells on the path to memory: lessons from influenza, Immunology & Cell Biology, 86, 4, 2008. Crossref
-
Xu Min, Lepisto Andrew J., Hendricks Robert L., Co-Stimulatory Requirements of Effector T Cells at Inflammatory Sites, DNA and Cell Biology, 21, 5-6, 2002. Crossref
-
Zhao Chunfang, Davies Joanna D., A peripheral CD4+ T cell precursor for naive, memory, and regulatory T cells, Journal of Experimental Medicine, 207, 13, 2010. Crossref
-
Landmeier Silke, Altvater Bianca, Pscherer Sibylle, Juergens Heribert, Varnholt Lena, Hansmeier Anna, Bollard Catherine M., Moosmann Andreas, Bisping Guido, Rossig Claudia, Activated Human γδ T Cells as Stimulators of Specific CD8+ T-cell Responses to Subdominant Epstein Barr Virus Epitopes, Journal of Immunotherapy, 32, 3, 2009. Crossref
-
Demoly P., Yssel H., Bousquet J., La réponse immunitaire locale dans la rhinite allergique, Revue Française d'Allergologie et d'Immunologie Clinique, 38, 7, 1998. Crossref
-
Adkinson N.Franklin, Essayan David, Gruchalla Rebecca, Haggerty Helen, Kawabata Thomas, Sandler J.David, Updyke Lawrence, Shear Neil H., Wierda Daniel, Task force report: Future research needs for the prevention and management of immune-mediated drug hypersensitivity reactions, Journal of Allergy and Clinical Immunology, 109, 3, 2002. Crossref
-
Rogers Paul R, Song Jianxun, Gramaglia Irene, Killeen Nigel, Croft Michael, OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells, Immunity, 15, 3, 2001. Crossref
-
Framson Paul E., Cho Diane H., Lee Lawrence Y., Hershberg Robert M., Polarized expression and function of the costimulatory molecule CD58 on human intestinal epithelial cells, Gastroenterology, 116, 5, 1999. Crossref
-
Demoly P., Bousquet J., Mucosal immune response to aeroallergens, Revue Française d'Allergologie et d'Immunologie Clinique, 41, 1, 2001. Crossref
-
Watson Andrew R.O., Mittler James N., Lee William T., Staphylococcal enterotoxin B induces anergy to conventional peptide in memory T cells, Cellular Immunology, 222, 2, 2003. Crossref
-
Gimsa Ulrike, Wolf Susanne A, Haas Dorit, Bechmann Ingo, Nitsch Robert, Th2 cells support intrinsic anti-inflammatory properties of the brain, Journal of Neuroimmunology, 119, 1, 2001. Crossref
-
Becker Kyra, Innate and adaptive immune responses in CNS disease, Clinical Neuroscience Research, 6, 5, 2006. Crossref
-
Vernot Jean-Paul, Perdomo-Arciniegas Ana María, Pérez-Quintero Luis Alberto, Martínez Diego Fernando, Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip fromHerpesvirus saimiri, Journal of Immunology Research, 2015, 2015. Crossref
-
Walther Michael, Popratiloff Anastas, Lachnit Nina, Hofmann Nils, Streppel Michael, Guntinas-Lichius Orlando, Neiss Wolfram F, Angelov Doychin N, Exogenous antigen containing perivascular phagocytes induce a non-encephalitogenic extravasation of primed lymphocytes, Journal of Neuroimmunology, 117, 1-2, 2001. Crossref
-
Hale Douglas A., Basic Transplantation Immunology, Surgical Clinics of North America, 86, 5, 2006. Crossref
-
Tekstra Janneke, Tjin Esther P.M., Tuk Cornelis W., Broekhuis-Fluitsma Donna, Havenith Carin E.G., Beelen Robert H.J., Analysis of Monocyte Chemotactic Protein-1 Production in Different Major Histocompatability Complex-Restricted Antigen Presentation Systems, Clinical Immunology, 101, 1, 2001. Crossref
-
Lasco Todd M., Cassone Lynne, Kamohara Hidenobu, Yoshimura Teizo, McMurray David N., Evaluating the role of tumor necrosis factor-alpha in experimental pulmonary tuberculosis in the guinea pig, Tuberculosis, 85, 4, 2005. Crossref
-
Zella Davide, Riva Agostino, Weichold Frank F, Reitz Jr Marvin S, Gerna Giuseppe, A novel sensitive assay to define immune status using short-term peripheral blood derived cell culture and dual-color flow cytometry, Immunology Letters, 62, 1, 1998. Crossref
-
Nabavieh Ali, Chou Henry, Volokhov Irina, Lee James E, Purdy Lisa E, Elliott John F, Singh Bhagirath, Madrenas Joaquı́n, Development of an I-Ag7-expressing Antigen-presenting Cell Line: Intrinsic Molecular Defect in Compact I-Ag7Dimer Generation, Journal of Autoimmunity, 11, 1, 1998. Crossref
-
Shrestha Badri, Haylor John, Raftery Andrew, Historical Perspectives in Kidney Transplantation: An Updated Review, Progress in Transplantation, 25, 1, 2015. Crossref
-
Trivedi Harsha N, HayGlass Kent T, Gangur Venugopal, Allardice James G, Embree Joanne E, Plummer Francis A, Analysis of Neonatal T Cell and Antigen Presenting Cell Functions, Human Immunology, 57, 2, 1997. Crossref
-
Williams Kelli M., Dotson Abby L., Otto Amber R., Kohlmeier Jacob E., Benedict Stephen H., Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation, Cellular Immunology, 271, 2, 2011. Crossref
-
Friedl Peter, Storim Julian, Diversity in immune-cell interactions: states and functions of the immunological synapse, Trends in Cell Biology, 14, 10, 2004. Crossref
-
Ulmer Artur J., Flad Hans-Dieter, Rietschel Th., Mattern Taila, Induction of proliferation and cytokine production in human T lymphocytes by lipopolysaccharide (LPS), Toxicology, 152, 1-3, 2000. Crossref
-
Witkowski Jacek M., Bryl Ewa, Paradoxical age-related cell cycle quickening of human CD4+ lymphocytes: a role for cyclin D1 and calpain, Experimental Gerontology, 39, 4, 2004. Crossref
-
Hui George, Hashimoto Caryn, The requirement of CD80, CD86, and ICAM-1 on the ability of adjuvant formulations to potentiate antibody responses to a Plasmodium falciparum blood-stage vaccine, Vaccine, 25, 51, 2007. Crossref
-
Lee Yunsang, Kug Eo Seong, Rouse Richard J.D, Rouse Barry T, Influence of CCR7 ligand DNA preexposure on the magnitude and duration of immunity, Virology, 312, 1, 2003. Crossref
-
Porras Flor, Urrea Francisco, Ortiz Blanca, Martínez-Cairo Salvador, Bouquelet Stéphane, Martínez Gisela, Lascurain Ricardo, Zenteno Edgar, Isolation of the receptor for the Amaranthus leucocarpus lectin from human T lymphocytes, Biochimica et Biophysica Acta (BBA) - General Subjects, 1724, 1-2, 2005. Crossref
-
Sporici Romeo A., Perrin Peter J., Costimulation of Memory T-Cells by ICOS: A Potential Therapeutic Target for Autoimmunity?, Clinical Immunology, 100, 3, 2001. Crossref
-
Maly Kathrin, Schirmer Michael, The Story of CD4+CD28−T Cells Revisited: Solved or Still Ongoing?, Journal of Immunology Research, 2015, 2015. Crossref
-
Gehring Svante, Schlaak Max, van der Bosch Jürgen, A new in vitro model for studying human T cell differentiation: TH1/TH2 induction following activation by superantigens, Journal of Immunological Methods, 219, 1-2, 1998. Crossref
-
Becker K.J., Sensitization and tolerization to brain antigens in stroke, Neuroscience, 158, 3, 2009. Crossref
-
van Wijk Femke, Knippels Léon, Initiating mechanisms of food allergy: Oral tolerance versus allergic sensitization, Biomedicine & Pharmacotherapy, 61, 1, 2007. Crossref
-
Lev Bar-Or Ruth, Feedback mechanisms between T helper cells and macrophages in the determination of the immune response, Mathematical Biosciences, 163, 1, 2000. Crossref
-
Bi Kun, Altman Amnon, Membrane lipid microdomains and the role of PKCθ in T cell activation, Seminars in Immunology, 13, 2, 2001. Crossref
-
Salek-Ardakani Shahram, Arrand John R., Mackett Mike, Epstein–Barr Virus Encoded Interleukin-10 Inhibits HLA-Class I, ICAM-1, and B7 Expression on Human Monocytes: Implications for Immune Evasion by EBV, Virology, 304, 2, 2002. Crossref
-
Watts Tania H, DeBenedettet Mark A, T cell co-stimulatory molecules other than CD28, Current Opinion in Immunology, 11, 3, 1999. Crossref
-
Danoff Theodore M., Neilson Eric G., Immunological Mechanisms of Interstitial Disease, in Seldin and Giebisch's The Kidney, 2008. Crossref
-
Cao Ling, Lawrence David A, Suppression of host resistance to Listeria monocytogenes by acute cold/restraint stress: lack of direct IL-6 involvement, Journal of Neuroimmunology, 133, 1-2, 2002. Crossref
-
Schmidt Clint S. , Liu Jinqi , Zhang Tonghai , Song Ho Yeong , Sandusky George , Mintze Karen , Benschop Robert J. , Glasebrook Andrew , Yang Derek D. , Na Songqing , Enhanced B Cell Expansion, Survival, and Humoral Responses by Targeting Death Receptor 6 , Journal of Experimental Medicine, 197, 1, 2003. Crossref
-
Curry Michael, Brooks Austin, Bruns Heather A., The Effect ofLonicera japonicaon LPS-Stimulated B-Cell Functions, Journal of Herbs, Spices & Medicinal Plants, 22, 2, 2016. Crossref
-
Watson Carrie L., Furlong Suzanne J., Hoskin David W., Impaired Interleukin-2 Synthesis and T Cell Proliferation Following Antibody-mediated CD3 and CD2 or CD28 Cross-linking inTrans: Evidence that T Cell Activation Requires the Engagement of Costimulatory Molecules Within the Immunological Synapse, Immunological Investigations, 37, 1, 2008. Crossref
-
Comrie William A., Burkhardt Janis K., Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse, Frontiers in Immunology, 7, 2016. Crossref
-
Jember Amha Gebre-Hiwot, Zuberi Riaz, Liu Fu-Tong, Croft Michael, Development of Allergic Inflammation in a Murine Model of Asthma Is Dependent on the Costimulatory Receptor Ox40, Journal of Experimental Medicine, 193, 3, 2001. Crossref
-
Pober Jordan S., Merola Jonathan, Liu Rebecca, Manes Thomas D., Antigen Presentation by Vascular Cells, Frontiers in Immunology, 8, 2017. Crossref
-
Gao Jianping, Morgan Grant, Tieu David D., Schwalb Tammy A., Ngo Mylinh, Stern Michael E., ICAM-1: Its Role in the Pathophysiology of Immune Activation in the MRL/LPR Mouse, in Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3, 506, 2002. Crossref
-
Bron Anthony J., de Paiva Cintia S., Chauhan Sunil K., Bonini Stefano, Gabison Eric E., Jain Sandeep, Knop Erich, Markoulli Maria, Ogawa Yoko, Perez Victor, Uchino Yuichi, Yokoi Norihiko, Zoukhri Driss, Sullivan David A., TFOS DEWS II pathophysiology report, The Ocular Surface, 15, 3, 2017. Crossref
-
Pernis Alessandra B., Review: The Role of IRF-4 in B and T Cell Activation and Differentiation, Journal of Interferon & Cytokine Research, 22, 1, 2002. Crossref
-
Hederer Rosemarie A., Guntermann Christine, Miller Nigel, Nagy Peter, Szollosi Janos, Damjanovich Sandor, Hale Geoffrey, Alexander Denis R., The CD45 tyrosine phosphatase regulates Campath-1H (CD52)-induced TCR-dependent signal transduction in human T cells, International Immunology, 12, 4, 2000. Crossref
-
Chen Chia-Lin, Huang Jeffrey Y., Wang Chun-Hsiang, Tahara Stanley M, Zhou Lin, Kondo Yasuteru, Schechter Joel, Su Lishan, Lai Michael M C., Wakita Takaji, Cosset François-Loïc, Jung Jae U, Machida Keigo, Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2, Nature Communications, 8, 1, 2017. Crossref
-
Fischer Hans-Georg, Dörfler Ruth, Schade Bartholomäus, Hadding Ulrich, Differential CD86/B7-2 expression and cytokine secretion induced by Toxoplasma gondii in macrophages from resistant or susceptible BALB H-2 congenic mice, International Immunology, 11, 3, 1999. Crossref
-
Rajnavölgyi Éva, Nagy Noémi, Thuresson Britt, Dosztányi Zsuzsa, Simon Ágnes, Simon István, Karr Robert W., Ernberg Ingemar, Klein Eva, Falk Kerstin I., A repetitive sequence of Epstein–Barr virus nuclear antigen 6 comprises overlapping T cell epitopes which induce HLA-DR-restricted CD4+ T lymphocytes, International Immunology, 12, 3, 2000. Crossref
-
Deng Jun, Dekruyff Rosemarie H., Freeman Gordon J., Umetsu Dale T., Levy Shoshana, Critical role of CD81 in cognate T–B cell interactions leading to Th2 responses, International Immunology, 14, 5, 2002. Crossref
-
Butler Jared J., Mader Jamie S., Watson Carrie L., Zhang Hong, Blay Jonathan, Hoskin David W., Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: Role of interleukin-2 and cyclic AMP signaling pathways, Journal of Cellular Biochemistry, 89, 5, 2003. Crossref
-
Hegde Venkatesh L., Singh Narendra P., Nagarkatti Prakash S., Nagarkatti Mitzi, CD44 mobilization in allogeneic dendritic cell-T cell immunological synapse plays a key role in T cell activation, Journal of Leukocyte Biology, 84, 1, 2008. Crossref
-
Pae Munkyong, Ren Zhihong, Meydani Mohsen, Shang Fu, Meydani Simin Nikbin, Wu Dayong, Epigallocatechin-3-Gallate Directly Suppresses T Cell Proliferation through Impaired IL-2 Utilization and Cell Cycle Progression, The Journal of Nutrition, 140, 8, 2010. Crossref
-
Gorczynski Reginald M., Chen Z., Zeng H., Fu X. M., A ROLE FOR PERSISTING ANTIGEN, ANTIGEN PRESENTATION, AND ICAM-1 IN INCREASED RENAL GRAFT SURVIVAL AFTER ORAL OR PORTAL VEIN DONOR-SPECIFIC IMMUNIZATION1, Transplantation, 66, 3, 1998. Crossref
-
Pinto Bruna, Medeiros Nayara, Fontes-Cal Tereza, Naziazeno Isabela, Correa-Oliveira Rodrigo, Dutra Walderez, Gomes Juliana, The Role of Co-Stimulatory Molecules in Chagas Disease, Cells, 7, 11, 2018. Crossref
-
Kim Bo-Geun, Song Youngju, Lee Mi-Gi, Ku Jin-Mo, Jin So-Jung, Hong Joung-Woo, Lee SeungGwan, Kang Hee, Macrophages from Mice Administered Rhus verniciflua Stokes Extract Show Selective Anti-Inflammatory Activity, Nutrients, 10, 12, 2018. Crossref
-
Wülfing Christoph, Rupp Fabio, Neuropilin-1: another neuronal molecule in the “immunological synapse”, Nature Immunology, 3, 5, 2002. Crossref
-
Kato T., Ito T., Imatani T., Minaguchi K., Saitoh E., Okuda K., Cystatin SA, a cysteine proteinase inhibitor, induces interferon-γ expression in CD4-positive T cells, Biological Chemistry, 385, 5, 2004. Crossref
-
Rogers Paul R., Croft Michael, CD28, Ox-40, LFA-1, and CD4 Modulation of Th1/Th2 Differentiation Is Directly Dependent on the Dose of Antigen, The Journal of Immunology, 164, 6, 2000. Crossref
-
Phillips Nancy E., Markees Thomas G., Mordes John P., Greiner Dale L., Rossini Aldo A., Blockade of CD40-Mediated Signaling Is Sufficient for Inducing Islet But Not Skin Transplantation Tolerance, The Journal of Immunology, 170, 6, 2003. Crossref
-
JOVANOVA-NESIC K., SHOENFELD Y., Autoimmunity in the Brain: The Pathogenesis Insight from Cell Biology, Annals of the New York Academy of Sciences, 1107, 1, 2007. Crossref
-
Sturm Andreas, Krivacic Kimberley A., Fiocchi Claudio, Levine Alan D., Dual Function of the Extracellular Matrix: Stimulatory for Cell Cycle Progression of Naive T Cells and Antiapoptotic for Tissue-Derived Memory T Cells, The Journal of Immunology, 173, 6, 2004. Crossref
-
Xu Zhenghai, Juan Veronica, Ivanov Alexander, Ma Zhiyuan, Polakoff Dixie, Powers David B., DuBridge Robert B., Wilson Keith, Akamatsu Yoshiko, Affinity and Cross-Reactivity Engineering of CTLA4-Ig To Modulate T Cell Costimulation, The Journal of Immunology, 189, 9, 2012. Crossref
-
Iwakoshi Neal N., Mordes John P., Markees Thomas G., Phillips Nancy E., Rossini Aldo A., Greiner Dale L., Treatment of Allograft Recipients with Donor-Specific Transfusion and Anti-CD154 Antibody Leads to Deletion of Alloreactive CD8+T Cells and Prolonged Graft Survival in a CTLA4-Dependent Manner, The Journal of Immunology, 164, 1, 2000. Crossref
-
Ingulli Elizabeth, Ulman Deborah R., Lucido Michelle M., Jenkins Marc K., In Situ Analysis Reveals Physical Interactions Between CD11b+ Dendritic Cells and Antigen-Specific CD4 T Cells After Subcutaneous Injection of Antigen, The Journal of Immunology, 169, 5, 2002. Crossref
-
Ito Satoshi, Ansari Parswa, Sakatsume Minoru, Dickensheets Harold, Vazquez Nancy, Donnelly Raymond P., Larner Andrew C., Finbloom David S., Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1, Blood, 93, 5, 1999. Crossref
-
Zhang Zong-Duan, Deng Yu-Xuan, Ma Hui-Xiang, Chen Xiao-Gang, Chen Lin-Hua, Qu Jia, Thymic Stromal Lymphopoietin-Related Allergic Pathway in Patients With Vernal Keratoconjunctivitis, Cornea, 38, 3, 2019. Crossref
-
Vella Anthony T., Uncovering the Differences between T Cell Tolerance and Immunity, in Autoimmunity, 2001. Crossref
-
Prasad Durbaka V. R., Nguyen Thang, Li Zhaoxia, Yang Yang, Duong Julie, Wang Ying, Dong Chen, Murine B7-H3 Is a Negative Regulator of T Cells, The Journal of Immunology, 173, 4, 2004. Crossref
-
Vallejo Abbe N., Mügge Lars O., Klimiuk Piotr A., Weyand Cornelia M., Goronzy Jörg J., Central Role of Thrombospondin-1 in the Activation and Clonal Expansion of Inflammatory T Cells, The Journal of Immunology, 164, 6, 2000. Crossref
-
Naisbitt Dean J., Gordon Sfraser, Pirmohamed Munir, Park Bkevin, Immunological Principles of Adverse Drug Reactions, Drug Safety, 23, 6, 2000. Crossref
-
Fleischer Jens, Grage-Griebenow Evelin, Kasper Brigitte, Heine Holger, Ernst Martin, Brandt Ernst, Flad Hans-Dieter, Petersen Frank, Platelet Factor 4 Inhibits Proliferation and Cytokine Release of Activated Human T Cells, The Journal of Immunology, 169, 2, 2002. Crossref
-
Sugie Katsuji, Huang Jianyong, GIF Inhibits Th Effector Generation by Acting on Antigen-Presenting B Cells, The Journal of Immunology, 166, 7, 2001. Crossref
-
Gramaglia Irene, Jember Amha, Pippig Susanne D., Weinberg Andrew D., Killeen Nigel, Croft Michael, The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion, The Journal of Immunology, 165, 6, 2000. Crossref
-
Ito Satoshi, Ansari Parswa, Sakatsume Minoru, Dickensheets Harold, Vazquez Nancy, Donnelly Raymond P., Larner Andrew C., Finbloom David S., Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1, Blood, 93, 5, 1999. Crossref
-
von Bergwelt-Baildon Michael S., Vonderheide Robert H., Maecker Britta, Hirano Naoto, Anderson Karen S., Butler Marcus O., Xia Zhinan, Zeng Wan Y., Wucherpfennig Kai W., Nadler Lee M., Schultze Joachim L., Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application, Blood, 99, 9, 2002. Crossref
-
Zhang Ping, Sun Deming, Ke Yan, Kaplan Henry J., Shao Hui, The Net Effect of Costimulatory Blockers Is Dependent on the Subset and Activation Status of the Autoreactive T Cells, The Journal of Immunology, 178, 1, 2007. Crossref
-
Modiano Jaime F., Mayor Jocelyne, Ball Carrie, Fuentes Maren K., Linthicum D. Scott, CDK4 Expression and Activity Are Required for Cytokine Responsiveness in T Cells, The Journal of Immunology, 165, 12, 2000. Crossref
-
Watson Andrew R. O., Lee William T., Differences in Signaling Molecule Organization between Naive and Memory CD4+T Lymphocytes, The Journal of Immunology, 173, 1, 2004. Crossref
-
Gurkan Sevgi, Schröppel Bernd, Murphy Barbara, Immunology of Organ Transplantation, in Pathology of Solid Organ Transplantation, 2009. Crossref
-
Kaufman Howard L, Kim-Schulze Seunghee, Manson Kelledy, DeRaffele Gail, Mitcham Josephine, Seo Kang Seok, Kim Dae Won, Marshall John, Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer, Journal of Translational Medicine, 5, 1, 2007. Crossref
-
Kasprowicz Deborah J., Kohm Adam P., Berton Michael T., Chruscinski Andrezj J., Sharpe Arlene, Sanders Virginia M., Stimulation of the B Cell Receptor, CD86 (B7-2), and the β2-Adrenergic Receptor Intrinsically Modulates the Level of IgG1 and IgE Produced per B Cell, The Journal of Immunology, 165, 2, 2000. Crossref
-
The Vertebrate Immune System, in Origin of Anti-Tumor Immunity Failure in Mammals, 2004. Crossref
-
Choudhury Arpita, Mukherjee Paushali, Basu Sandip K., George Anna, Rath Satyajit, Bal Vineeta, Disruption of T Cell Tolerance to Self-Immunoglobulin Causes Polyclonal B Cell Stimulation Followed by Inactivation of Responding Autoreactive T Cells, The Journal of Immunology, 164, 4, 2000. Crossref
-
Prasad Durbaka V. R., Parekh Vrajesh V., Joshi Bimba N., Banerjee Pinaki P., Parab Pradeep B., Chattopadhyay Samit, Kumar Anil, Mishra Gyan C., The Th1-Specific Costimulatory Molecule, M150, Is a Posttranslational Isoform of Lysosome-Associated Membrane Protein-1, The Journal of Immunology, 169, 4, 2002. Crossref
-
Hilden Tiina J., Valmu Leena, Kärkkäinen Satu, Gahmberg Carl G., Threonine Phosphorylation Sites in the β2and β7Leukocyte Integrin Polypeptides, The Journal of Immunology, 170, 8, 2003. Crossref
-
Notter Michael, Willinger Tim, Erben Ulrike, Thiel Eckhard, Targeting of a B7-1 (CD80) immunoglobulin G fusion protein to acute myeloid leukemia blasts increases their costimulatory activity for autologous remission T cells, Blood, 97, 10, 2001. Crossref
-
Friedmann-Morvinski Dinorah, Bendavid Alain, Waks Tova, Schindler Daniel, Eshhar Zelig, Redirected primary T cells harboring a chimeric receptor require costimulation for their antigen-specific activation, Blood, 105, 8, 2005. Crossref
-
Büning Jürgen, Hundorfean Gheorghe, Schmitz Martina, Zimmer Klaus‐Peter, Strobel Stephan, Gebert Andreas, Ludwig Diether, Antigen targeting to MHC class II‐enriched late endosomes in colonic epithelial cells: trafficking of luminal antigens studied in vivo in Crohn's colitis patients, The FASEB Journal, 20, 2, 2006. Crossref
-
Croft Michael, Gramaglia Irene, Cooper David, Immunological Accessory Molecules, in eLS, 2001. Crossref
-
Roszkowska Anna Maria, Oliverio Giovanni William, Aragona Emanuela, Inferrera Leandro, Severo Alice Antonella, Alessandrello Federica, Spinella Rosaria, Postorino Elisa Imelde, Aragona Pasquale, Ophthalmologic Manifestations of Primary Sjögren’s Syndrome, Genes, 12, 3, 2021. Crossref
-
Banu Nazifa, Meyers Catherine M., IFN-γ and LPS differentially modulate class II MHC and B7-1 expression on murine renal tubular epithelial cells, Kidney International, 55, 6, 1999. Crossref
-
Vancheri Carlo, Mastruzzo Claudio, Trovato-Salinaro Elisa, Gili Elisa, Lo Furno Debora, Pistorio Maria P, Caruso Massimo, La Rosa Cristina, Crimi Claudia, Failla Marco, Crimi Nunzio, Interaction between human lung fibroblasts and T-lymphocytes prevents activation of CD4+ cells, Respiratory Research, 6, 1, 2005. Crossref
-
Foger N., Marhaba R., Zoller M., Involvement of CD44 in cytoskeleton rearrangement and raft reorganization in T cells, Journal of Cell Science, 114, 6, 2001. Crossref
-
Cornish T., Chi J., Johnson S., Lu Y., Campanelli J.T., Globular domains of agrin are functional units that collaborate to induce acetylcholine receptor clustering, Journal of Cell Science, 112, 8, 1999. Crossref
-
Banu Nazifa, Meyers Catherine M., TGF-β1 down-regulates induced expression of both class II MHC and B7-1 on primary murine renal tubular epithelial cells, Kidney International, 56, 3, 1999. Crossref
-
Muczynski Kimberly A., Ekle David M., Coder David M., Anderson Susan K., Normal Human Kidney HLA-DR–Expressing Renal Microvascular Endothelial Cells: Characterization, Isolation, and Regulation of MHC Class II Expression, Journal of the American Society of Nephrology, 14, 5, 2003. Crossref
-
Whetter Linda, Novembre Francis J., Saucier Michelle, Gummuluru Suryaram, Dewhurst Stephen, Costimulatory Pathways in Lymphocyte Proliferation Induced by the Simian Immunodeficiency Virus SIVsmmPBj14, Journal of Virology, 72, 7, 1998. Crossref
-
Moore R. N., Hessle Christina, Andersson Bengt, Wold Agnes E., Gram-Positive Bacteria Are Potent Inducers of Monocytic Interleukin-12 (IL-12) while Gram-Negative Bacteria Preferentially Stimulate IL-10 Production, Infection and Immunity, 68, 6, 2000. Crossref
-
Stevanović S, van Schie M L J, Griffioen M, Falkenburg J H, HLA-class II disparity is necessary for effective T cell mediated Graft-versus-Leukemia effects in NOD/scid mice engrafted with human acute lymphoblastic leukemia, Leukemia, 27, 4, 2013. Crossref
-
Katae Masaharu, Miyahira Yasushi, Takeda Kazuyoshi, Matsuda Hironori, Yagita Hideo, Okumura Ko, Takeuchi Tsutomu, Kamiyama Tsuneo, Ohwada Akihiko, Fukuchi Yoshinosuke, Aoki Takashi, Coadministration of an Interleukin-12 Gene and a Trypanosoma cruzi Gene Improves Vaccine Efficacy , Infection and Immunity, 70, 9, 2002. Crossref
-
Wülfing Christoph, Davis Mark M., A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation, Science, 282, 5397, 1998. Crossref
-
Ogasawara Masaru, Yamasaki-Yashiki Shino, Hamada Masahiro, Yamaguchi-Miyamoto Tomomi, Kawasuji Toru, Honda Hiroe, Yanagibashi Tsutomu, Ikutani Masashi, Watanabe Yasuharu, Fujimoto Ryota, Matsunaga Takayuki, Nakajima Noriyuki, Nagai Yoshinori, Takatsu Kiyoshi, Betulin Attenuates TGF-β1- and PGE<sub>2</sub>-Mediated Inhibition of NK Cell Activity to Suppress Tumor Progression and Metastasis in Mice, Biological and Pharmaceutical Bulletin, 45, 3, 2022. Crossref
-
Glushakova Svetlana, Grivel Jean-Charles, Suryanarayana Kalachar, Meylan Pascal, Lifson Jeffrey D., Desrosiers Ronald, Margolis Leonid, Nef Enhances Human Immunodeficiency Virus Replication and Responsiveness to Interleukin-2 in Human Lymphoid Tissue Ex Vivo, Journal of Virology, 73, 5, 1999. Crossref
-
Palma M L, Duangkhae P, Douradinha B, Viana I F T, Rigato P O, Dhalia R, Mailliard R B, Barratt-Boyes S M, Nascimento E J M, Oshiro T M, da Silva Duarte A J, Marques E T A, Development of potent class II transactivator gene delivery systems capable of inducing de novo MHC II expression in human cells, in vitro and ex vivo, Gene Therapy, 24, 6, 2017. Crossref
-
Witherden Deborah A., Verdino Petra, Rieder Stephanie E., Garijo Olivia, Mills Robyn E., Teyton Luc, Fischer Wolfgang H., Wilson Ian A., Havran Wendy L., The Junctional Adhesion Molecule JAML Is a Costimulatory Receptor for Epithelial γδ T Cell Activation, Science, 329, 5996, 2010. Crossref
-
Tuomanen E. I., Yun Peter L. W., Decarlo Arthur A., Collyer Charles, Hunter Neil, Hydrolysis of Interleukin-12 by Porphyromonas gingivalis Major Cysteine Proteinases May Affect Local Gamma Interferon Accumulation and the Th1 or Th2 T-Cell Phenotype in Periodontitis , Infection and Immunity, 69, 9, 2001. Crossref
-
Miyahira Yasushi, Akiba Hisaya, Ogawa Shu-Hei, Ishi Tomohiro, Watanabe Shiho, Kobayashi Seiki, Takeuchi Tsutomu, Aoki Takashi, Tezuka Katsunari, Abe Ryo, Okumura Ko, Yagita Hideo, Watanabe Naohiro, Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections, Immunology Letters, 89, 2-3, 2003. Crossref
-
Wülfing Christoph, Sjaastad Michael D., Davis Mark M., Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels, Proceedings of the National Academy of Sciences, 95, 11, 1998. Crossref
-
Gerloni Mara, Xiong Sidong, Mukerjee Sonjoy, Schoenberger Stephen P., Croft Michael, Zanetti Maurizio, Functional cooperation between T helper cell determinants, Proceedings of the National Academy of Sciences, 97, 24, 2000. Crossref
-
Miyahira Yasushi, Katae Masaharu, Kobayashi Seiki, Takeuchi Tsutomu, Fukuchi Yoshinosuke, Abe Ryo, Okumura Ko, Yagita Hideo, Aoki Takashi, Critical Contribution of CD28-CD80/CD86 Costimulatory Pathway to Protection from Trypanosoma cruzi Infection , Infection and Immunity, 71, 6, 2003. Crossref
-
Zanetti Maurizio, Croft Michael, Immunological Memory, in eLS, 2001. Crossref
-
Uzonna Jude E., Kaushik Radhey S., Zhang Ying, Gordon John R., Tabel Henry, Experimental MurineTrypanosoma congolenseInfections. II. Role of Splenic Adherent CD3+ Thy1.2+ TCR-αβ− γδ− CD4+8− and CD3+ Thy1.2+ TCR-αβ− γδ− CD4−8− Cells in the Production of IL-4, IL-10, and IFN-γ and in Trypanosome-Elicited Immunosuppression, The Journal of Immunology, 161, 11, 1998. Crossref
-
Rogers Paul R., Grey Howard M., Croft Michael, Modulation of Naive CD4 T Cell Activation with Altered Peptide Ligands: The Nature of the Peptide and Presentation in the Context of Costimulation Are Critical for a Sustained Response, The Journal of Immunology, 160, 8, 1998. Crossref
-
Geginat J., Bossi G., Bender J. R., Pardi R., Anchorage Dependence of Mitogen-Induced G1 to S Transition in Primary T Lymphocytes, The Journal of Immunology, 162, 9, 1999. Crossref
-
Gramaglia Irene, Weinberg Andrew D., Lemon Michael, Croft Michael, Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses, The Journal of Immunology, 161, 12, 1998. Crossref
-
Ohshima Y., Yang L-P., Avice M-N., Kurimoto M., Nakajima T., Sergerie M., Demeure C. E., Sarfati M., Delespesse G., Naive Human CD4+ T Cells Are a Major Source of Lymphotoxin α, The Journal of Immunology, 162, 7, 1999. Crossref
-
Qin Dahui, Wu Jiuhua, Carroll Michael C., Burton Gregory F., Szakal Andras K., Tew John G., Evidence for an Important Interaction Between a Complement-Derived CD21 Ligand on Follicular Dendritic Cells and CD21 on B Cells in the Initiation of IgG Responses, The Journal of Immunology, 161, 9, 1998. Crossref