Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Immunology
Fator do impacto: 1.404 FI de cinco anos: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472

Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v19.i5-6.20
41 pages

Cell Adhesion Molecules: Selectins and Integrins

Roberto González-Amaro
Department of Immunology, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., México
Francisco Sanchez-Madrid
Sección de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain


Cell adhesion molecules play a key role in different physiological and pathological phenomena. Selectins comprise a family of three members (E-, P-, and L-selectin) that are differentially expressed by leukocytes and endothelial cells, and are involved in the early steps of leukocyte extravasation. Although many different putative ligands of selectins have been described, their physiological relevance has not been elucidated in all cases. Selectins and some of their counter-receptors function also as signal-transducing receptors, significantly contributing to leukocyte and endothelial cell activation. Integrins represent a large family of adhesion receptors that are widely expressed and mainly interact with extracellular matrix components. The affinity and avidity of integrins can be modulated by different mechanisms triggered either from the extracellular milieu or through intracellular signals. Integrins show a close relationship with cytoskeleton and exert an important role as signal-transducing receptors, activating different biochemical pathways, mainly the mitogen-activated protein (MAP) kinase cascade. In addition to their adhesive function, these receptors modulate key intracellular phenomena, including cell activation, proliferation, and apoptosis. Because selectins and integrins are involved in leukocyte extravasation and the inflammatory response, different strategies are in progress for the blockade of these molecules and, therefore, for therapy of inflammatory diseases.

Articles with similar content:

Immune Functions of Proteinase 3
Critical Reviews™ in Immunology, Vol.25, 2005, issue 5
Shunji Sugawara
Emerging Roles of CCCH-Type Zinc Finger Proteins in Destabilizing mRNA Encoding Inflammatory Factors and Regulating Immune Responses
Critical Reviews™ in Eukaryotic Gene Expression, Vol.25, 2015, issue 1
Shaofei Huang, Chuanbin Yang, Yong Gu, Xuanbin Wang
HDAC6-Dependent Functions in Tumor Cells: Crossroad with the MAPK Pathways
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 1-2
Wenlong Bai, Joshua Haakenson, Kendra A. Williams, Xiaohong Zhang, Shengyan Xiang, Jheng-Yu Wu
The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease
Critical Reviews™ in Immunology, Vol.36, 2016, issue 4
Veronica M. Ringel-Scaia, Irving C. Allen, Dylan K. McDaniel
Exosomes, Ectosomes and the Two Together. Physiology and Pathology
Onco Therapeutics, Vol.6, 2015, issue 3-4
Jacopo Meldolesi