Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Immunology
Fator do impacto: 1.404 FI de cinco anos: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472

Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v19.i5-6.10
40 pages

Transplantation Tolerance: A Look at the Nonhuman Primate Literature in the Light of Modern Tolerance Theories

Allan D. Kirk
NIDDK/Navy-Transplant and Autoimmunity Branch, 10 Center Drive, Bldg. 10, Room 11S219, Bethesda, MD 20892


Ever since the beginning of clinical transplantation, investigators have searched for a way to transplant tissues from one person to another without chronic immunosuppression. That goal, known as allograft tolerance, has remained clinically elusive. In the past decade, however, many of the fundamental principles of tolerance have been redefined, and biological agents capable of exploiting them in vivo have been developed. Accordingly, experimental methods for tolerance induction have rapidly evolved in concert with a growing understanding of physiological tolerance to self and the development of novel immunoreactive reagents. In general, old world monkeys have become the pre-clinical testing ground for methods that have shown reasonable promise for clinical application, particularly antibodies or other biological agents with limited cross-species reactivity. As such, a survey of the nonhuman primate experience in transplantation is representative of all reasonably successful experimental attempts to develop clinically applicable tolerance regimens. This article summarizes many of the concepts currently unfolding in the tolerance literature. It also reviews the techniques for tolerance induction that have been and are currently being investigated in nonhuman primates. The validity of these models is summarized, and the older literature is reinterpreted in light of recent changes in our understanding of tolerance.

Articles with similar content:

DNA Vaccines
Critical Reviews™ in Immunology, Vol.18, 1998, issue 5
Wayne C. Lai, Michael Bennett
Stem Cells: A New Paradigm in Medical Therapeutics
Journal of Long-Term Effects of Medical Implants, Vol.20, 2010, issue 3
Sadanand D. Mankikar
Past and Future of the Molecular Characterization of the T Cell Repertoire: Some Highlights of Eli Sercarz's Contributions
Critical Reviews™ in Immunology, Vol.40, 2020, issue 3
Antonella Di Pino, Gabriele Di Sante, Maria Tredicine, Francesco Ria, Simona Rolla
CD1d-Mediated Antigen Presentation to Natural Killer T (NKT) Cells
Critical Reviews™ in Immunology, Vol.23, 2003, issue 5-6
Tonya J. Roberts, Venkataraman Sriram, Yinling Lin, Sungyoo Cho, Randy R. Brutkiewicz, Yu Kyeong Hwang
Bone Tissue Engineering: Recent Advances and Challenges
Critical Reviews™ in Biomedical Engineering, Vol.40, 2012, issue 5
Syam P. Nukavarapu, Cato T. Laurencin, Ami R. Amini