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Critical Reviews™ in Therapeutic Drug Carrier Systems

Publicou 6 edições por ano

ISSN Imprimir: 0743-4863

ISSN On-line: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Reviewing Biophysical and Cell Biological Methodologies in Cell-Penetrating Peptide (CPP) Research

Volume 24, Edição 3, 2007, pp. 203-255
DOI: 10.1615/CritRevTherDrugCarrierSyst.v24.i3.10
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RESUMO

The discovery of cell-penetrating peptides (CPPs), which have the ability to translocate across the plasma membranes of mammalian cells, has led to widespread optimism for delivery of problematic therapeutic cargoes to cells. These cargoes include peptide, protein, and nucleic acid biopharmaceuticals and even nano-sized vectors such as liposomes and nanoparticles. Research on CPPs includes biophysical studies of membrane models to investigate fundamental principles of CPP-lipid membrane interactions as well as cell studies focusing on the efficiency of uptake, mechanisms of translocation, and toxicity. However, both lines of research have suffered from misinterpretation as well as premature extrapolations. In this review, we provide a critical evaluation of the potential and limitations of selected biophysical methodologies such as fluorescence spectroscopy, circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy, atomic-force microscopy (AFM), and non-spectroscopic methods. We include a discussion of the most important bilayer membrane models in CPP research. We then evaluate important cell biological methodologies, in particular confocal laser scanning microscopy (CLSM) and fluorescence-associated cell sorting (FACS) in combination with various techniques to distinguish between translocated and non-translocated CPPs. Moreover, we discuss the diverse methodologies for tracing the pathways of CPP translocation and their routes of intracellular trafficking.

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