Publicou 6 edições por ano
ISSN Imprimir: 0743-4863
ISSN On-line: 2162-660X
Indexed in
Polymeric Immunonanoparticles Mediated Cancer Therapy: Versatile Nanocarriers for Cell-Specific Cargo Delivery
RESUMO
The major drawback with conventional therapeutic approaches for cancer therapy is decreased efficacy and redundant therapy associated toxicity and side effects causing increased patient discomfort. With the aim of minimizing these limitations, a vast amount of attention has been given to targeted nanocarrier–based drug delivery systems that possess a several-fold advantage over conventional therapy. Increased research in targeted nanoparticulate systems has led to the development of immunonanoparticles with enhanced efficacy and targeting efficiency along with decreased drug-resistant cancer- and dose-related toxicity. These immunonanoparticle- based therapies, which can be extended to immunotherapy, have gained wide attention, but few formulations will be approved by regulatory agencies in the near future. This review details the various immunonanoparticle systems explored in cancer therapy, with particular emphasis on polymeric nanoparticles. This review describes the mechanisms of immunotherapy and the pathways for targeting dendritic cells for immunotherapy. It also focuses on present status of clinical trials of immunonanoparticles and related patents, as well as various FDA-approved monoclonal antibodies (mAbs) for immunotherapy. Toxicity issues related to immunonanoparticles along with regulatory guidelines for these therapeutic nanoparticles are also discussed.
-
Dhas Namdev, Parekh Khushali, Pandey Abhijeet, Kudarha Ritu, Mutalik Srinivas, Mehta Tejal, Two dimensional carbon based nanocomposites as multimodal therapeutic and diagnostic platform: A biomedical and toxicological perspective, Journal of Controlled Release, 308, 2019. Crossref
-
Su Tianqi, Yang Bo, Gao Tianren, Liu Tongjun, Li Jiannan, Polymer nanoparticle-assisted chemotherapy of pancreatic cancer, Therapeutic Advances in Medical Oncology, 12, 2020. Crossref
-
Pandey Abhijeet, Dhas Namdev, Deshmukh Prashant, Caro Carlos, Patil Pravin, Luisa García-Martín Maria, Padya Bharath, Nikam Ajinkya, Mehta Tejal, Mutalik Srinivas, Heterogeneous surface architectured metal-organic frameworks for cancer therapy, imaging, and biosensing: A state-of-the-art review, Coordination Chemistry Reviews, 409, 2020. Crossref
-
Bhargava Arpit, Mishra Dinesh Kumar, Tiwari Rajnarayan, Lohiya Nirmal Kumar, Goryacheva Irina Yu, Mishra Pradyumna Kumar, Immune cell engineering: opportunities in lung cancer therapeutics, Drug Delivery and Translational Research, 10, 5, 2020. Crossref
-
Dhas Namdev, Mehta Tejal, Sharma Shilpa, Garkal Atul, Yadav Dattatray, Hariharan Kartik, Shamjetshabam Babeeta, Khot Shubham, Kudarha Ritu, Bangar Priyanka, Arbade Gajanan, Kalyankar Pratap, Intranasal gene therapy for the treatment of neurological disorders, in Direct Nose-to-Brain Drug Delivery, 2021. Crossref
-
Verma Amit, Tiwari Ankita, Saraf Shivani, Panda Pritish Kumar, Jain Ankit, Jain Sanjay K., Emerging potential of niosomes in ocular delivery, Expert Opinion on Drug Delivery, 18, 1, 2021. Crossref
-
Dhas Namdev, Yadav Dattatray, Singh Ashutosh, Garkal Atul, Kudarha Ritu, Bangar Priyanka, Savjani Jignasa, Pardeshi Chandrakantsing V., Garg Neha, Mehta Tejal, Direct transport theory: From the nose to the brain, in Direct Nose-to-Brain Drug Delivery, 2021. Crossref
-
Dhas Namdev, Kudarha Ritu, Pandey Abhijeet, Nikam Ajinkya N., Sharma Shilpa, Singh Ashutosh, Garkal Atul, Hariharan Kartik, Singh Amanpreet, Bangar Priyanka, Yadhav Dattatray, Parikh Dhaivat, Sawant Krutika, Mutalik Srinivas, Garg Neha, Mehta Tejal, Stimuli responsive and receptor targeted iron oxide based nanoplatforms for multimodal therapy and imaging of cancer: Conjugation chemistry and alternative therapeutic strategies, Journal of Controlled Release, 333, 2021. Crossref
-
Moradi Rahman, Mohammadzadeh Reza, Akbari Ali, Kappa-Carrageenan Crosslinked Magnetic Folic Acid-Conjugated Chitosan Nanocomposites for Arginase Encapsulation, Delivery and Cancer Therapy, Nano LIFE, 11, 03, 2021. Crossref
-
Viswanath Dixita Ishani, Liu Hsuan-Chen, Huston David P., Chua Corrine Ying Xuan, Grattoni Alessandro, Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines, Biomaterials, 280, 2022. Crossref