Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Therapeutic Drug Carrier Systems
Fator do impacto: 2.9 FI de cinco anos: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimir: 0743-4863
ISSN On-line: 2162-660X

Volumes:
Volume 36, 2019 Volume 35, 2018 Volume 34, 2017 Volume 33, 2016 Volume 32, 2015 Volume 31, 2014 Volume 30, 2013 Volume 29, 2012 Volume 28, 2011 Volume 27, 2010 Volume 26, 2009 Volume 25, 2008 Volume 24, 2007 Volume 23, 2006 Volume 22, 2005 Volume 21, 2004 Volume 20, 2003 Volume 19, 2002 Volume 18, 2001 Volume 17, 2000 Volume 16, 1999 Volume 15, 1998 Volume 14, 1997 Volume 13, 1996 Volume 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v22.i3.20
pages 295-330

Advances in Buccal Drug Delivery

Raj Birudaraj
TJL School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California, USA. Current address: Roche Palo Alto, Palo Alto, California, USA
Ravichandran Mahalingam
TJL School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California, USA
Xiaoling Li
Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211
Bhaskara R. Jasti
Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211

RESUMO

The buccal route offers an attractive alternative for systemic drug delivery of drugs because of better patient compliance, ease of dosage form removal in emergencies, robustness, and good accessibility. Use of buccal mucosa for drug absorption was first attempted by Sobrero in 1847, and since then much research was done to deliver drugs through this route. Today, research is more focused on the development of suitable delivery devices, permeation enhancement, and buccal delivery of drugs that undergo a first-pass effect, such as cardiovascular drugs, analgesics, and peptides. In addition, studies have been conducted on the development of controlled or slow release delivery systems for systemic and local therapy of diseases in the oral cavity. In this review, the anatomy and physiology of buccal mucosa, followed by discussion of recent literature on the buccal permeation enhancement, and pathways of enhancement for various molecules are detailed. In addition, bioadhesion theories from historic perspective and current status are discussed. The various dosage forms on the market and in different stages of development are also reviewed.


Articles with similar content:

Overview on Therapeutic Applications of Microparticulate Drug Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 4
Swarna Bale, Mandip Singh, A. Shiva Shankar Reddy, Amit Khurana, Chandraiah Godugu
Sublingual Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.25, 2008, issue 5
Bhaskara R. Jasti, Xiaoling Li, Tarun Goswami
Microsponges: A Pioneering Tool for Biomedical Applications
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 1
Amit Verma, Ankit Jain, Pooja Hurkat, Amrita Kumari, Sanjay Kumar Jain
Engineered PLGA Nanoparticles: An Emerging Delivery Tool in Cancer Therapeutics
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 1
Amit K. Jain, Manasmita Das, Nitin K. Swarnakar, Sanyog Jain
Microemulsions: An Overview and Pharmaceutical Applications
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.16, 1999, issue 5
Srini Tenjarla