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Critical Reviews™ in Therapeutic Drug Carrier Systems

Publicou 6 edições por ano

ISSN Imprimir: 0743-4863

ISSN On-line: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Structuring Polymers for Delivery of DNA-Based Therapeutics: Updated Insights

Volume 29, Edição 6, 2012, pp. 447-485
DOI: 10.1615/CritRevTherDrugCarrierSyst.v29.i6.10
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RESUMO

Gene therapy offers greater opportunities for treating numerous incurable diseases from genetic disorders, infections, and cancer. However, development of appropriate delivery systems could be one of the most important factors to overcome numerous biological barriers for delivery of various therapeutic molecules. A number of nonviral polymer-mediated vectors have been developed for DNA delivery and offer the potential to surmount the associated problems of their viral counterpart. To address the concerns associated with safety issues, a wide range of polymeric vectors are available and have been utilized successfully to deliver their therapeutics in vivo. Today's research is mainly focused on the various natural or synthetic polymer-based delivery carriers that protect the DNA molecule from degradation, which offer specific targeting to the desired cells after systemic administration, have transfection efficiencies equivalent to virus-mediated gene delivery, and have long-term gene expression through sustained-release mechanisms. This review explores an updated overview of different nonviral polymeric delivery system for delivery of DNA-based therapeutics. These polymeric carriers have been evaluated in vitro and in vivo and are being utilized in various stages of clinical evaluation. Continued research and understanding of the principles of polymer-based gene delivery systems will enable us to develop new and efficient delivery systems for the delivery of DNA-based therapeutics to achieve the goal of efficacious and specific gene therapy for a vast array of clinical disorders as the therapeutic solutions of tomorrow.

CITADO POR
  1. Fuchs Hendrik, Bachran Christopher, Flavell David, Diving through Membranes: Molecular Cunning to Enforce the Endosomal Escape of Antibody-Targeted Anti-Tumor Toxins, Antibodies, 2, 4, 2013. Crossref

  2. Paproski Robert J., Zemp Roger J., Comparing nanodroplets and microbubbles for enhancing ultrasound-mediated gene transfection, 2013 IEEE International Ultrasonics Symposium (IUS), 2013. Crossref

  3. HO YOONKHEI, TOO HENG-PHON, CATIONIC POLYMER BASED GENE DELIVERY: UPTAKE AND INTRACELLULAR TRAFFICKING, COSMOS, 10, 01, 2014. Crossref

  4. Kuo Jung-Hua Steven, Jan Ming-Shiou, Lin Chia-Wei, Molecular Mechanisms Underlying Cell Death Caused by Cationic Polymers, in Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 2016. Crossref

  5. Raup Alexander, Stahlschmidt Ullrich, Jérôme Valérie, Synatschke Christopher, Müller Axel, Freitag Ruth, Influence of Polyplex Formation on the Performance of Star-Shaped Polycationic Transfection Agents for Mammalian Cells, Polymers, 8, 6, 2016. Crossref

  6. Vandghanooni Somayeh, Eskandani Morteza, Barar Jaleh, Omidi Yadollah, Bispecific therapeutic aptamers for targeted therapy of cancer: a review on cellular perspective, Journal of Molecular Medicine, 96, 9, 2018. Crossref

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