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Critical Reviews™ in Therapeutic Drug Carrier Systems
Fator do impacto: 2.9 FI de cinco anos: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimir: 0743-4863
ISSN On-line: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v25.i3.10
pages 207-258

Mucoadhesion and the Gastrointestinal Tract

Felipe J. O. Varum
Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra 3000-295, Portugal; and Department of Pharmaceutics, The School of Pharmacy, University of London, London WC1N 1 AX, UK
Emma L. McConnell
Department of Pharmaceutics, The School of Pharmacy, University of London, London WC1N 1 AX, UK
Joao J. S. Sousa
Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra 3000-295, Portugal
Francisco Veiga
Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra 3000-295, Portugal
Abdul W. Basit
Department of Pharmaceutics, The School of Pharmacy, University of London, London WC1N 1 AX, UK

RESUMO

The concept of mucoadhesion is one that has the potential to improve the highly variable residence times experienced by drugs and dosage forms at various sites in the gastrointestinal tract, and consequently, to reduce variability and improve efficacy. Intimate contact with the mucosa should enhance absorption or improve topical therapy. A variety of approaches have been investigated for mucoadhesion in the gastrointestinal tract, particularly for the stomach and small intestine. Despite interesting results in these sites, mucoadhesive approaches have not yet shown success in humans. The potential of the lower gut for these applications has been largely neglected, although the large intestine in particular may benefit, and the colon has several factors that suggest mucoadhesion could be successful there, including lower motility and the possibility of a lower mucus turnover and thicker mucus layer. In vitro studies on colonic mucoadhesion show promise, and rectal administration has shown some positive results in vivo. This review considers the background to mucoadhesion with respect to the physiological conditions of the gastrointestinal tract as well as the principles that underlie this concept. Mucoadhesive approaches to gastrointestinal drug delivery will be examined, with particular attention given to the lower gut.


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