Publicou 6 edições por ano
ISSN Imprimir: 0743-4863
ISSN On-line: 2162-660X
Indexed in
Novel Methods of Insulin Delivery: An Update
RESUMO
Conventional insulin therapies involve multiple daily subcutaneous injections. However, the resultant disposition of insulin and blood glucose differs considerably from that following the physiological secretion of pancreatic insulin. A variety of alternative routes/methods have been investigated to improve systemic insulin delivery. Peroral and nasal insulin administration have demonstrated good potential for the treatment of diabetes. Facilitated transdermal delivery has also enjoyed success in promoting the systemic delivery of insulin. In addition, pulmonary, buccal, and ocular insulin administration have been shown to decrease serum glucose concentrations. Other methods that have been investigated for their potential in systemic insulin delivery include rectal, vaginal, and uterine routes.
-
Shibata Nobuhito, Ito Yukako, Takada Kanji, Pharmacokinetics, in Pharmaceutical Sciences Encyclopedia, 2010. Crossref
-
Lyubimov Alexander V., Dosage Formulation, in Pharmaceutical Sciences Encyclopedia, 2010. Crossref
-
Bellary Srikanth, Barnett Anthony H, Inhaled human insulin: a clinical perspective, Therapy, 3, 3, 2006. Crossref
-
Adams Gary, Clark Jan, Sahota Tarsem, Tanna Sangeeta, Taylor M. Joan, Diabetes Mellitus and Closed-Loop Insulin Delivery, Biotechnology and Genetic Engineering Reviews, 17, 1, 2000. Crossref
-
Lin Congrong, Gokhale Rajeev, Trivedi Jay S., Ranade Vasant, Recent strategies and methods for improving insulin delivery, Drug Development Research, 63, 4, 2004. Crossref
-
Roach Paris, New Insulin Analogues and Routes of Delivery, Clinical Pharmacokinetics, 47, 9, 2008. Crossref
-
Higaki Megumu, Kameyama Mieko, Udagawa Masae, Ueno Yukio, Yamaguchi Yoko, Igarashi Rie, Ishihara Tsutomu, Mizushima Yutaka, Transdermal Delivery of CaCO3-Nanoparticles Containing Insulin, Diabetes Technology & Therapeutics, 8, 3, 2006. Crossref
-
Brock William J., Peroral Toxicity, in General and Applied Toxicology, 2009. Crossref
-
Hamishehkar Hamed, Emami Jaber, Najafabadi Abdolhossien Rouholamini, Gilani Kambiz, Minaiyan Mohsen, Hassanzadeh Kambiz, Mahdavi Hamid, Koohsoltani Maryam, Nokhodchi Ali, Pharmacokinetics and pharmacodynamics of controlled release insulin loaded PLGA microcapsules using dry powder inhaler in diabetic rats, Biopharmaceutics & Drug Disposition, 2010. Crossref
-
King Martin J., Badea Ildiko, Solomon Jason, Kumar Praveen, Gaspar Kimberly J., Foldvari Marianna, Transdermal Delivery of Insulin from a Novel Biphasic Lipid System in Diabetic Rats, Diabetes Technology & Therapeutics, 4, 4, 2002. Crossref
-
BELLARY S., BARNETT A. H., Inhaled insulin: new technology, new possibilities, International Journal of Clinical Practice, 60, 6, 2006. Crossref
-
Yarbakht Melina, Jalali-Javaran Mokhtar, Nikkhah Maryam, Mohebodini Mehdi, Dicistronic expression of human proinsulin-protein A fusion in tobacco chloroplast, Biotechnology and Applied Biochemistry, 62, 1, 2015. Crossref
-
Ramachandran Rukmani, Paul Willi, Sharma Chandra P., Synthesis and characterization of PEGylated calcium phosphate nanoparticles for oral insulin delivery, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 88B, 1, 2009. Crossref
-
Petrus Amanda K., Vortherms Anthony R., Fairchild Timothy J., Doyle Robert P., Vitamin B12 as a Carrier for the Oral Delivery of Insulin, ChemMedChem, 2, 12, 2007. Crossref
-
Simon Michael, Wittmar Matthias, Kissel Thomas, Linn Thomas, Insulin Containing Nanocomplexes Formed by Self-Assembly from Biodegradable Amine-Modified Poly(Vinyl Alcohol)-Graft-Poly(l-Lactide): Bioavailability and Nasal Tolerability in Rats, Pharmaceutical Research, 22, 11, 2005. Crossref
-
Tam Jasmine M., McConville Jason T., Williams Robert O., Johnston Keith P., Amorphous cyclosporin nanodispersions for enhanced pulmonary deposition and dissolution, Journal of Pharmaceutical Sciences, 97, 11, 2008. Crossref
-
Jain Akhlesh K., Chalasani Kishore B., Khar Roop K., Ahmed Farhan J., Diwan Prakash V., Muco-adhesive multivesicular liposomes as an effective carrier for transmucosal insulin delivery, Journal of Drug Targeting, 15, 6, 2007. Crossref
-
Sintov Amnon C., Levy Haim V., Botner Shafir, Systemic delivery of insulin via the nasal route using a new microemulsion system: In vitro and in vivo studies, Journal of Controlled Release, 148, 2, 2010. Crossref
-
Cefalu William T, Evaluation of alternative strategies for optimizing glycemia: progress to date, The American Journal of Medicine, 113, 6, 2002. Crossref
-
Caliceti Paolo, Veronese Francesco M, Lora Silvano, Polyphosphazene microspheres for insulin delivery, International Journal of Pharmaceutics, 211, 1-2, 2000. Crossref
-
Sintov Amnon C., Wormser Uri, Topical iodine facilitates transdermal delivery of insulin, Journal of Controlled Release, 118, 2, 2007. Crossref
-
Momoh Mumuni A., Kenechukwu Franklin C., Nnamani Petra O., Umetiti Jennifer C., Influence of magnesium stearate on the physicochemical and pharmacodynamic characteristics of insulin-loaded Eudragit entrapped mucoadhesive microspheres, Drug Delivery, 22, 6, 2015. Crossref
-
Deutel Britta, Laffleur Flavia, Palmberger Thomas, Saxer Andreas, Thaler Marlene, Bernkop-Schnürch Andreas, In vitro characterization of insulin containing thiomeric microparticles as nasal drug delivery system, European Journal of Pharmaceutical Sciences, 81, 2016. Crossref
-
Furtado Stacia, Abramson Danielle, Simhkay Liat, Wobbekind Daniel, Mathiowitz Edith, Subcutaneous delivery of insulin loaded poly(fumaric-co-sebacic anhydride) microspheres to type 1 diabetic rats, European Journal of Pharmaceutics and Biopharmaceutics, 63, 2, 2006. Crossref
-
Singh R.K, Kim W.-S, Ollinger M, Craciun V, Coowantwong I, Hochhaus G, Koshizaki N, Laser based synthesis of nanofunctionalized particulates for pulmonary based controlled drug delivery applications, Applied Surface Science, 197-198, 2002. Crossref
-
Sheikh Hasan A., Sapin A., Damgé C., Leroy P., Socha M., Maincent P., Reduction of the in vivo burst release of insulin-loaded microparticles, Journal of Drug Delivery Science and Technology, 30, 2015. Crossref
-
Transdermal drug delivery, in Drug Delivery Systems, Second Edition, 2003. Crossref
-
Shenoy Dinesh B., D'Souza Reshma J., Tiwari Sandip B., Udupa N., Potential Applications of Polymeric Microsphere Suspension as Subcutaneous Depot for Insulin, Drug Development and Industrial Pharmacy, 29, 5, 2003. Crossref
-
Miscellaneous forms of drug delivery, in Drug Delivery Systems, Second Edition, 2003. Crossref
-
Dan Nily, Core–shell drug carriers: liposomes, polymersomes, and niosomes, in Nanostructures for Drug Delivery, 2017. Crossref
-
Bellary Srikanth, Barnett Anthony H, Inhaled insulin (Exubera®): combining efficacy and convenience, Diabetes and Vascular Disease Research, 3, 3, 2006. Crossref
-
Dan Nily, Vesicle-based drug carriers, in Design and Development of New Nanocarriers, 2018. Crossref
-
Goldberg Michael, Gomez-Orellana Isabel, Challenges for the oral delivery of macromolecules, Nature Reviews Drug Discovery, 2, 4, 2003. Crossref
-
Bellary Srikanth, Barnett Anthony H, Review: Inhaled insulin: overcoming barriers to insulin therapy?, The British Journal of Diabetes & Vascular Disease, 6, 3, 2006. Crossref
-
Bindra Sanjit S., Cefalu William T., Alternative approaches to subcutaneous insulin injections, Current Opinion in Endocrinology & Diabetes, 9, 4, 2002. Crossref
-
Owens David R., New horizons — alternative routes for insulin therapy, Nature Reviews Drug Discovery, 1, 7, 2002. Crossref
-
Cefalu William T, Evolving Strategies for Insulin Delivery and Therapy, Drugs, 64, 11, 2004. Crossref
-
Garg Ashish, Garg Sweta, Pandey Prakash, Madamsetty Vijay Sagar, Mishra Neeraj, Mucoadhesive Drug Delivery System in Chronic Respiratory Diseases, in Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases, 2022. Crossref
-
Cefalu William T., Concept, Strategies, and Feasibility of Noninvasive Insulin Delivery , Diabetes Care, 27, 1, 2004. Crossref
-
Heller Simon, Kozlovski Plamen, Kurtzhals Peter, Insulin's 85th anniversary—An enduring medical miracle, Diabetes Research and Clinical Practice, 78, 2, 2007. Crossref