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Critical Reviews™ in Oncogenesis
SJR: 0.946 SNIP: 0.503 CiteScore™: 2

ISSN Imprimir: 0893-9675
ISSN On-line: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2014012554
pages 19-34

Altered Expression of Histone Deacetylases in Cancer

Diana Montezuma
Department of Pathology, Cancer Biology & Epigenetics Group, Research Center, Portuguese Oncology Institute-Porto (Cl-IPO-Porto), Rua Dr. Antonio Bernardino Almeida, 4200-072, Porto, Portugal
Rui Manuel Ferreira Henrique
Department of Pathology, Portuguese Oncology Institute—Porto; and Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Sa-lazar (ICBAS), University of Porto, Portugal
Carmen Jeronimo
Cancer Biology & Epigenetics Group, Research Center, Portuguese Oncology Institute-Porto (Cl-IPO-Porto), Rua Dr. Antonio Bernardino Almeida, 4200-072, Porto, Portugal; Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences

RESUMO

Epigenetic mechanisms, including histone deacetylation, are commonly deregulated in cancer. Histone deacetylases (HDACs) play an important role in tumorigenesis and their value as therapeutic targets has been under intense investigation in recent years. In addition to classical HDACs (HDAC classes I, II, and IV), sirtuins (class III HDACs) are currently in the spotlight of cancer research showing promise as cancer biomarkers and therapeutic targets. Translating research knowledge into the clinical setting is, however, a challenging and demanding task. This review describes the association between HDAC deregulation and cancer promotion and highlights recent advances in the use of HDAC inhibitors in the management of neoplastic diseases, with emphasis on urological tumors. Sirtuins' bivalent role in tumor development and therapeutic agents targeting these molecules will be also addressed.


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