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Critical Reviews™ in Oncogenesis

Publicou 4 edições por ano

ISSN Imprimir: 0893-9675

ISSN On-line: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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The Possible Interactions and Therapeutic Roles of Lithium Chloride and Midkine on Cancer Treatment

Volume 24, Edição 1, 2019, pp. 35-45
DOI: 10.1615/CritRevOncog.2018029410
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RESUMO

Midkine (MK) is a heparin-binding anti-apoptotic growth factor or cytokine also known as neurite growth-promoting factor 2 (NEGF2). It is developmentally an important retinoic acid-responsive gene product strongly induced during the mid-gestation stage. Midkine promotes different cellular events such as cell growth, differentiation, survival, gene expression, and drug resistence. Midkine, the phosphatidylinositol 3-kinases (PI3-kinase, PI3K) and glycogen synthase kinase-3 beta (GSK-3β) inhibitors together with lithium chloride may be a very effective treatment modality, especially in tumors with high expression of these two molecules. PI3 kinase and GSK-3β, both serine threonine kinases located in the center of the signaling network, are very important regulator molecules for cell survival or death. Lithium chloride (LiCl), with its newly discovered antineoplastic effect and cytotoxicity potentiation, has become a promising agent in the application of new combination treatments. Although the LiCl mechanism of action is still not fully understood, previous studies have shown that LiCl is an inhibitör of the inositol monophosphatase (IMPase) and GSK-3β. GSK-3β, is a serine-threonine protein kinase involved in cell proliferation, differentiation, survival, apotosis, and tumorogenesis. The role of GSK-3β in tumorigenesis and cancer remains controversial. It may have a function as a tumor suppressor for certain types of tumors, but it promotes cell growth and development in other tumor types.

CITADO POR
  1. Chen George G., Woo Peter Y.M., Ng Stephanie C.P., Wong George K.C., Chan Danny T.M., van Hasselt Charles A., Tong Michael C.F., Poon Wai Sang, Impact of metformin on immunological markers: Implication in its anti-tumor mechanism, Pharmacology & Therapeutics, 213, 2020. Crossref

  2. Wang Yen-Yun, Hung Amos C., Lo Steven, Hsieh Ya-Ching, Yuan Shyng-Shiou F., MRE11 as a molecular signature and therapeutic target for cancer treatment with radiotherapy, Cancer Letters, 514, 2021. Crossref

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