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Critical Reviews™ in Oncogenesis
SJR: 0.946 SNIP: 0.503 CiteScore™: 2

ISSN Imprimir: 0893-9675
ISSN On-line: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2019029628
pages 99-104

Cancer and Cancer Stem Cells: New Molecular Perspectives

Cevik Gurel
Ege University, Faculty of Medicine, Department of Histology and Embryology, Izmir, Turkey
Gizem Inetas
Ege University, Institute of Health Sciences, Department of Stem Cell, Izmir, Turkey
Ismet Hortu
Ege University, Faculty of Medicine, Department of Obstetrics and Gynecology, Izmir, Turkey
Elif Tunc
Izmir Katip Celebi University, Ataturk Training and Research Hospital, Depertment of Cardiology, Izmir, Turkey
Gokce Ceren Kuscu
Ege University, Faculty of Medicine, Department of Histology and Embryology, Izmir, Turkey
Funda Cagirir Dindaroglu
Izmir Katip Celebi University, Faculty of Dentistry, Department of Pedodontics, Izmir, Turkey
Onur Sahin
Izmir Katip Celebi University, Faculty of Dentistry, Department of Pedodontics, Izmir, Turkey
Aylin Buhur
Ege University, Faculty of Medicine, Department of Histology and Embryology, Izmir, Turkey
Gulperi Oktem
Ege University, Faculty of Medicine, Department of Histology and Embryology, Izmir, Turkey; Ege University, Institute of Health Sciences, Department of Stem Cell, Izmir, Turkey

RESUMO

Cancer, which causes the deaths of millions of people, is an important public health problem worldwide. Despite significant advances in the diagnosis and treatment of cancer, survival rates are still insufficient in progressive cancers. Today, one of the most important reasons for not being able to reach the desired level in the fight against progressive cancer types is cancer stem cells (CSCs). The ineffectiveness of conventional therapies on CSCs has made it necessary to investigate the molecular mechanisms and signaling pathways used in the survival, drug resistance, and metastasis of CSCs. In this context, studies investigating the biology of CSCs suggest that lipid metabolism and extracellular vesicles are critical for understanding the stemness and metastasis of these cells. These studies have demonstrated that a number of molecules play a vital role in resistant to apoptosis in CSCs, including the cellular FLICE-inhibitor protein (c-FLIP), which inhibits TRAIL-induced extrinsic apoptosis. Another important output of these studies is the demonstration of the relationship of the cancer microenvironment in terms of epithelial–mesenchymal transition, which CSCs frequently use in the metastasis process. In addition, studies investigating the differences in glycosylation observed in CSCs and investigating cancer vaccines are promisng. These findings will strengthen our aresnal in the fight against cancer. In this article, we summarize current molecular studies on CSCs, an important target in novel cancer therapies.


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