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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Imprimir: 0893-9675
ISSN On-line: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2018027408
pages 333-346

Herbal Medicine in the Mitigation of Reactive Oxygen Species, Autophagy, and Cancer: A Review

Anna Marzvanyan
AT Still University School of Osteopathic Medicine, Mesa, AZ
Vicky Chen
Columbia University School of Nursing, New York, NY
Boshi Zhang
Division of Growth and Development, Section of Orthodontics, UCLA School of Dentistry, Los Angeles, CA
Greg Asatrian
Division of Growth and Development, Section of Orthodontics, UCLA School of Dentistry, Los Angeles, CA


Since the discovery of autophagy in the mid-2000s, the interest in autophagy-related processes within the scientific community has been burgeoning. Countless authors have investigated its function in cellular homeostasis, but arguably of higher importance is its role during pathology. Although primarily a catabolic process, in cancer cells autophagy has numerous downstream effects, being observed to be both pro- and anti-apoptotic. One of the primary factors mediating this differential role of autophagy is the accumulation or sequestration of reactive oxygen species (ROS). Until recently, despite its increasing popularity in the Western world, the efficacy of herbal supplements has been largely anecdotal. Herein, we reviewed the ten most commonly studied herbs in cancer research and their impact on ROS regulation, on the activation and inhibition of autophagy, and ultimately on cancer cell death.

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