Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Imprimir: 0893-9675
ISSN On-line: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2018028394
pages 269-280

Mechanism and Regulation of Autophagy in Cancer

Uma Maheswari
DBT-IPLS Programme, Department of Biochemistry and Molecular Biology, Pondicherry University, Pondicherry, India
Sudha Rani Sadras
DBT-IPLS Programme, Department of Biochemistry and Molecular Biology, Pondicherry University, Pondicherry, India


Autophagy, or self-eating, is a catabolic process that plays a crucial role in cellular homeostasis by carrying out bulk degradation of defective or superfluous proteins as well as worn-out organelles through a specialized structure, the autophagosome, which in turn fuses with the lysosome. Autophagy also alleviates cellular stress induced by nutrient deprivation, metabolic disturbance, hypoxia, and the like, by recycling intracellular constituents. This role of autophagy, to provide metabolic precursors especially upon starvation, might also contribute to the survival of cancer cells. The role of autophagy in cancer cells is ambiguous given that its downregulation or upregulation has been observed to depend on cancer stage and pathological grade. Autophagy has been found to exhibit a dual effect on tumorigenesis where it functions to suppress tumor progression by eliminating factors that cause genome instability while promoting survival of cancer cells under unfavorable conditions like therapeutic stress. This review aims to explain the mechanism, regulation, and the dual role of autophagy in cancer.

Articles with similar content:

Autophagy and Hallmarks of Cancer
Critical Reviews™ in Oncogenesis, Vol.23, 2018, issue 5-6
Namratha Sastry, Xuechao Wan, Angel A. Alvarez, Haizhong Feng, Shi-Yuan Cheng, Xiao Song, Bo Hu, Tianzhi Huang, Yongyong Yang
Linking Autophagy and the Dysregulated NFκB/ SNAIL/YY1/RKIP/PTEN Loop in Cancer: Therapeutic Implications
Critical Reviews™ in Oncogenesis, Vol.23, 2018, issue 5-6
Benjamin Bonavida
Antitumoral Activity of Sorafenib in Hepatocellular Carcinoma: Effects on Cell Survival and Death Pathways, Cell Metabolism Reprogramming, and Nitrosative and Oxidative Stress
Critical Reviews™ in Oncogenesis, Vol.21, 2016, issue 5-6
Francisco J. Padillo, Jordi Muntané, Maria A. Rodriguez-Hernandez, Elena Navarro-Villaran, Raul Gonzalez, Francisco J. Molina-Ruiz
Phosphorylation-Based Signaling in Fas Receptor-Mediated Apoptosis
Critical Reviews™ in Immunology, Vol.20, 2000, issue 2
John E. Eriksson, Tim H. Holmstrom
Autophagy in tumor suppression and cancer therapy
Critical Reviews™ in Eukaryotic Gene Expression, Vol.21, 2011, issue 1
Marika K. Bergenstock, Anna Budina, Maureen Murphy, Gregor Balaburski, Che-Pei Kung