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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Imprimir: 0893-9675
ISSN On-line: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v7.i5-6.40
pages 457-464

The Current Role of Radiotherapy in the Treatment of Invasive Bladder Cancer

Rashmi K. Benda
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Ml 48202
Arthur T. Porter
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Ml 48202

RESUMO

Invasive bladder cancer remains a therapeutic challenge. Approximately 50% of patients treated with radical cystectomy die of metastatic disease. External beam radiation therapy when given alone has results inferior to that of surgery, and although it has shown some benefit when given in the preoperative setting, this was not verified by randomized trials. Altered fractionation radiation schemes and combined modality using a cisplatin-based combination chemotherapy with radiation have resulted in up to 60% bladder preservation.


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