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Critical Reviews™ in Oncogenesis

Publicou 4 edições por ano

ISSN Imprimir: 0893-9675

ISSN On-line: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Current Perspectives of Exosomes as Therapeutic Targets and Drug Delivery Vehicles for Pancreatic Cancer

Volume 24, Edição 2, 2019, pp. 179-190
DOI: 10.1615/CritRevOncog.2019031202
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RESUMO

The ever-growing interest in exosomes research is mainly due to their potential applications in health and disease, especially in therapy and diagnosis. To explore the applications of exosomes in the clinical setting, we must understand their characteristics at the molecular levels. Furthermore, exosomes are cell and function specific; therefore, we must ascertain the molecular mechanisms of their biogenesis, cellular recognition, and uptake. In the recent past, engineered exosomes and exosome mimetics have been the subject of active research. However, critical facets of the biology of engineered exosomes and exosome mimetics remain unknown. This review presents our current understanding of the potential role of engineered exosomes and exosome mimetics in diagnosis, prognosis, monitoring of treatment, as well as drug delivery. We also present recent updates on the exosome signature, its role in pancreatic cancer progression, and applications in the delivery of natural therapeutics and RNAi molecules and in the immune response. Lastly, we discuss future prospects and challenges of exosomes in translational studies.

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CITADO POR
  1. Desjardins Pascale, Berthiaume Rébecca, Couture Camille, Le-Bel Gaëtan, Roy Vincent, Gros-Louis François, Moulin Véronique J., Proulx Stéphanie, Chemtob Sylvain, Germain Lucie, Guérin Sylvain L., Impact of Exosomes Released by Different Corneal Cell Types on the Wound Healing Properties of Human Corneal Epithelial Cells, International Journal of Molecular Sciences, 23, 20, 2022. Crossref

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