Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Imprimir: 0893-9675
ISSN On-line: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v11.i1.10
17 pages

Dendritic Cell-Based Vaccines: From Mouse Models to Clinical Cancer Immunotherapy

Marco W. J. Schreurs
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands
Andreas A. O. Eggert
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands
Cornells J. A. Punt
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands
Carl G. Figdor
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands
Gosse J. Adema
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands

RESUMO

B and T lymphocytes are the effectors of specific immunity. However, their function is critically dependent on dendritic cells (DC). DC are professional antigen presenting cells that both initiate and modulate the immune response. The recent breakthrough in the generation of DC from their progenitors has stimulated research on DC in both fundamental and clinical immunology. Objective immune response induction has now been reported in clinical studies using DC. In this review we discuss the development and potential of DC-based vaccines to induce antitumor immunity.


Articles with similar content:

Transcriptional Analysis of Tumor-Specific T-Cell Responses in Cancer Patients
Critical Reviews™ in Immunology, Vol.22, 2002, issue 5-6
Ena Wang, Jos Even, Dirk Nagorsen, Francesco M. Marincola
Dendritic Cell Tumor Killing Activity and Its Potential Applications in Cancer Immunotherapy
Critical Reviews™ in Immunology, Vol.33, 2013, issue 1
Neale Hanke, Darya Alizadeh, Nicolas Larmonier, Emmanuel Katsanis
Acquisition and Presentation of Tumor Antigens by Dendritic Cells
Critical Reviews™ in Immunology, Vol.35, 2015, issue 5
Guido Ferlazzo, Stefania Campana, Irene Bonaccorsi, Barbara Morandi
CD28/B7 Costimulation: A Review
Critical Reviews™ in Immunology, Vol.18, 1998, issue 5
Khuong A. Nguyen, Vijay K. Kuchroo, Edward A. Greenfield
Dendritic Cell-Derived Exosomes as Cell-Free Peptide-Based Vaccines
Critical Reviews™ in Immunology, Vol.25, 2005, issue 3
Julien Taieb, Nathalie Chaput, Laurence Zitvogel