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Critical Reviews™ in Oncogenesis

Publicou 4 edições por ano

ISSN Imprimir: 0893-9675

ISSN On-line: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Animal Models of Uveal Melanoma for Localized Interventions

Volume 22, Edição 3-4, 2017, pp. 187-194
DOI: 10.1615/CritRevOncog.2018024510
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RESUMO

Uveal melanoma is the most common primary intraocular malignancy in adults, carrying a significant risk for death from metastatic disease. Treatment efforts aim toward local tumor control and early detection and management of metastases. Animal models are a valuable tool in the study of the molecular, genetic, and cellular events associated with the development of uveal melanoma and the evaluation of the therapeutic potential for various treatment methods. So far, several spontaneous, transgenetic, or induced animal models have been used, each presenting distinct advantages and disadvantages. This review article systematically presents an analysis of these animal models aimed at localized interventions; We aim to assist researchers with the selection of the optimal animal model based on their particular research targets.

CITADO POR
  1. Richards Jackson R., Yoo Jae Hyuk, Shin Donghan, Odelberg Shannon J., Mouse models of uveal melanoma: Strengths, weaknesses, and future directions, Pigment Cell & Melanoma Research, 33, 2, 2020. Crossref

  2. Sharif Najam A., Genetics and other techniques to create novel animal models for ocular research, in Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics, 2022. Crossref

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