Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Journal of Porous Media
Fator do impacto: 1.49 FI de cinco anos: 1.159 SJR: 0.43 SNIP: 0.671 CiteScore™: 1.58

ISSN Imprimir: 1091-028X
ISSN On-line: 1934-0508

Volumes:
Volume 22, 2019 Volume 21, 2018 Volume 20, 2017 Volume 19, 2016 Volume 18, 2015 Volume 17, 2014 Volume 16, 2013 Volume 15, 2012 Volume 14, 2011 Volume 13, 2010 Volume 12, 2009 Volume 11, 2008 Volume 10, 2007 Volume 9, 2006 Volume 8, 2005 Volume 7, 2004 Volume 6, 2003 Volume 5, 2002 Volume 4, 2001 Volume 3, 2000 Volume 2, 1999 Volume 1, 1998

Journal of Porous Media

DOI: 10.1615/JPorMedia.v12.i3.10
pages 201-212

Molecular Transport through Arterial Wall Composed of Smooth Muscle Cells and a Homogeneous Fiber Matrix

Mahsa Dabagh
Department of Energy and Environmental Technology, Lappeenranta University of Technology, 53851, Lappeenranta, Finland
Payman Jalali
Department of Energy and Environmental Technology, Lappeenranta University of Technology, 53851, Lappeenranta, Finland
Pertti Sarkomaa
Department of Energy and Environmental Technology, Lappeenranta University of Technology, 53851, Lappeenranta, Finland
Yrjo T. Konttinen
Department of Orthopaedics, Teaching Hospital, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Department of Orthopaedics, ORTON Orthopaedic Hospital, 00280 Helsinki, Finland; COXA Hospital for Joint Replacement, 33520 Tampere, Finland

RESUMO

The molecular transport through an arterial wall is significantly influenced by the shape, distribution, and volume fraction of smooth muscle cells (SMCs). In the present study, a two-dimensional numerical simulation is performed to investigate the influence of the configuration of SMCs on the diffusion of Adenosine 5'-triphosphate (ATP) through the media layer of the arterial wall. The media layer is modeled as a heterogeneous porous medium composed of smooth muscle cells embedded in a continuous porous medium representing the interstitial proteoglycan and collagen fiber matrix. SMCs are distributed within the media layer in either ordered or disordered fashions at different volume fractions. The interstitial fluid enters the media through fenestral pores which are distributed uniformly over the internal elastic lamina (IEL). The probability density function (PDF) of the concentration of ATP is analyzed within the bulk in the presence of elliptic SMCs, which shows it to be lower than that in the presence of circular cells with the SMC volume fraction of 0.4. Moreover, the distribution of SMCs considerably affects the PDF of ATP within the bulk with the volume fraction of 0.7. Results indicate the importance of SMCs in the transport of molecules such as ATP within the arterial wall.


Articles with similar content:

STOCHASTIC CONSOLIDATION OF MULTILAYERED SOIL WITH RANDOM HEIGHT
Special Topics & Reviews in Porous Media: An International Journal, Vol.1, 2010, issue 4
M'hammed Badaoui
MONOLITHICALLY-COUPLED FINITE ELEMENT ANALYSIS USING IMPLICIT INTEGRATION SCHEME FOR A PARTIALLY SATURATED POROUS MEDIUM
Journal of Porous Media, Vol.18, 2015, issue 1
Jaejun Lee, Jaehong Kim
THERMODIFFUSION EFFECTS ON LDL DEPOSITION IN A CURVED ARTERY
ICHMT DIGITAL LIBRARY ONLINE, Vol.0, 2017, issue
Marcello Iasiello, Assunta Andreozzi, Kambiz Vafai, Nicola Bianco
Numerical Analysis of Grashof and Darcy Number Effects on Dissipative Natural Convection Boundary Layers in a Micropolar Fluid-Saturated Geological Porous Medium
International Journal of Fluid Mechanics Research, Vol.34, 2007, issue 4
Rama Bhargava, Tasveer A. Beg, Harmindar S. Takhar, S. Rawat, O. Anwar Bég
Endothelial Monocyte-Activating Polypeptide-II: Properties, Functions, and Pathogenetic Significance
International Journal of Physiology and Pathophysiology, Vol.7, 2016, issue 2
Alexander I. Kornelyuk, Vadim F. Sagach, A. E. Malyna, Liliya A. Mogylnytska, Nataliya A. Dorofeyeva