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Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Imprimir: 0278-940X
ISSN On-line: 1943-619X

Volumes:
Volume 47, 2019 Volume 46, 2018 Volume 45, 2017 Volume 44, 2016 Volume 43, 2015 Volume 42, 2014 Volume 41, 2013 Volume 40, 2012 Volume 39, 2011 Volume 38, 2010 Volume 37, 2009 Volume 36, 2008 Volume 35, 2007 Volume 34, 2006 Volume 33, 2005 Volume 32, 2004 Volume 31, 2003 Volume 30, 2002 Volume 29, 2001 Volume 28, 2000 Volume 27, 1999 Volume 26, 1998 Volume 25, 1997 Volume 24, 1996 Volume 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v37.i4-5.10
pages 283-320

Molecular Aspects of Cardiac Differentiation in Embryonic Stem Cells

Prasenjit Sarkar
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA
Balaji M. Rao
Department of Chemical and Biomolecular Engineering, North Carolina State University, USA

RESUMO

Embryonic stem cells (ESCs) are culture-adapted pluripotent cells derived from the inner cell mass of the blastocyst-stage embryo. ESCs provide unique opportunities to study the molecular basis of the process of differentiation that gives rise to all the somatic cell types of the body, including cells of the cardiac lineages. Many protocols have been established to obtain cells of the cardiac lineage from ESCs in vitro. More recently, a clearer picture of the regulatory networks governing cardiac differentiation has begun to emerge. Herein, we summarize the current methods to obtain cells of the cardiac lineages from ESCs and present a review of the signaling pathways, transcription factors, and target genes involved in cardiac differentiation.