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Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Imprimir: 0278-940X
ISSN On-line: 1943-619X

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Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.2018027003
pages 369-397

A Review of Recent Advances in Endovascular Therapy for Intracranial Aneurysms

Akshat M. Pai
Department of Surgery, Division of Neurosurgery, McMaster University, Hamilton, Canada
Michelle Kameda-Smith
Department of Surgery, Division of Neurosurgery, McMaster University, Hamilton, Canada
Brian van Adel
Department of Surgery, Division of Adult Neurology, McMaster University, Hamilton, Canada


Despite the advances in neuro-interventional techniques and expertise to treat intracranial aneurysms (IAs), there remains a subset of IAs that are considered to be a significant treatment challenge. Working closely with the neuro-interventional community, bioengineers have harnessed their knowledge of anatomy, physiology, biophysics, and new materials to develop novel therapeutic adjuncts for the successful endovascular treatment of simple and complex IAs. This review describes the biological challenges, the landscape of neuro-interventional management of IAs, and the factors pertinent to which therapeutic modality is recommended. Finally, recent technological advances that have emerged over the last decade are discussed, taking the reader through the devices' objectives, utility, and safety profiles. The goal of this review is to (i) provide physicians treating IAs with the pertinent information to facilitate evidence-based clinical decision thereby minimizing morbidity and mortality and (ii) facilitate professionals in the biomedical engineering field with the clinical background and summarize current endovascular IA treatment options available, with the intent to inspire future IA device development and innovation.

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